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mask multiple ankyrin repeats single KH domain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50070, updated on 9-Dec-2024

Summary

Official Symbol
maskprovided by FlyBase
Official Full Name
multiple ankyrin repeats single KH domainprovided by FlyBase
Primary source
FLYBASE:FBgn0043884
Locus tag
Dmel_CG33106
See related
AllianceGenome:FB:FBgn0043884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18671; CG31138; CG33106; CG6268; cg6313; CG6313; Dmel\CG33106; EC3-6; Mask; MASK
Summary
Enables protein kinase binding activity. Involved in several processes, including cellular component assembly involved in morphogenesis; negative regulation of establishment of blood-brain barrier; and positive regulation of signal transduction. Located in M band; Z disc; and cytosol. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 readthrough); ANKHD1 (ankyrin repeat and KH domain containing 1); and ANKRD17 (ankyrin repeat domain 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See mask in Genome Data Viewer
Location:
95F3-95F5; 3-84 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24230562..24250248)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20056284..20075970)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45217 Neighboring gene Spase 22/23-subunit Neighboring gene long non-coding RNA:CR44092 Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 95EF Neighboring gene small Cajal body-specific RNA : MeU2-G25 Neighboring gene Phenylalanyl-tRNA synthetase, beta-subunit Neighboring gene jaguar Neighboring gene transfer RNA:Leucine-TAA 4-1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in compound eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in flight IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy of mitochondrion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of establishment of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of sevenless signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in wound healing, spreading of cells IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in wound healing, spreading of epidermal cells IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
multiple ankyrin repeats single KH domain
Names
CG33106-PA
CG33106-PB
CG33106-PC
CG33106-PD
CG33106-PE
CG33106-PF
mask-PA
mask-PB
mask-PC
mask-PD
mask-PE
mask-PF

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24230562..24250248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260351.1NP_001247280.1  multiple ankyrin repeats single KH domain, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247280.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K725, A0A0H4XWY3
    Conserved Domains (7) summary
    smart00248
    Location:23212349
    ANK; ankyrin repeats
    cd00105
    Location:30493110
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:633751
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:635724
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:9951046
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:716771
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:633661
    ANK; ANK repeat [structural motif]
  2. NM_176556.2NP_788733.1  multiple ankyrin repeats single KH domain, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788733.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NP19, Q8SX96, Q8T0H2, Q8T8Q4, Q8WRQ7, Q9VCA8
    UniProtKB/TrEMBL
    A0A0H4XWY3
    Related
    FBpp0083947
    Conserved Domains (5) summary
    PHA03095
    Location:604859
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:621649
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:623713
    Ank_2; Ankyrin repeats (3 copies)
    cl00098
    Location:30383107
    KH-I; K homology (KH) RNA-binding domain, type I
    cl39094
    Location:23822701
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_001275975.1NP_001262904.1  multiple ankyrin repeats single KH domain, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262904.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHR8, A0A0H4XWY3
    Conserved Domains (7) summary
    smart00248
    Location:23112339
    ANK; ankyrin repeats
    cd00105
    Location:30393100
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:621739
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:623712
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:9831034
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:704759
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:621649
    ANK; ANK repeat [structural motif]
  4. NM_176557.2NP_788734.1  multiple ankyrin repeats single KH domain, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788734.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NP19, Q8SX96, Q8T0H2, Q8T8Q4, Q8WRQ7, Q9VCA8
    UniProtKB/TrEMBL
    A0A0H4XWY3
    Related
    FBpp0083948
    Conserved Domains (5) summary
    PHA03095
    Location:604859
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:621649
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:623713
    Ank_2; Ankyrin repeats (3 copies)
    cl00098
    Location:30383107
    KH-I; K homology (KH) RNA-binding domain, type I
    cl39094
    Location:23822701
    Ank_2; Ankyrin repeats (3 copies)
  5. NM_001275974.1NP_001262903.1  multiple ankyrin repeats single KH domain, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262903.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHZ8, A0A0H4XWY3
    Conserved Domains (7) summary
    smart00248
    Location:19471975
    ANK; ankyrin repeats
    cd00105
    Location:26752736
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:256374
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:258347
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:618669
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:339394
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:256284
    ANK; ANK repeat [structural motif]
  6. NM_001300571.1NP_001287500.1  multiple ankyrin repeats single KH domain, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287500.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHK4, A0A0H4XWY3
    Conserved Domains (7) summary
    smart00248
    Location:19341962
    ANK; ankyrin repeats
    cd00105
    Location:26622723
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:243361
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:245334
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:605656
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:326381
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:243271
    ANK; ANK repeat [structural motif]