U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ppp4r4 protein phosphatase 4, regulatory subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500711, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ppp4r4provided by RGD
Official Full Name
protein phosphatase 4, regulatory subunit 4provided by RGD
Primary source
RGD:1560932
See related
EnsemblRapid:ENSRNOG00000054052 AllianceGenome:RGD:1560932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560932
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in cytosol. Predicted to be part of protein serine/threonine phosphatase complex. Orthologous to human PPP4R4 (protein phosphatase 4 regulatory subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 62.9), Brain (RPKM 42.3) and 5 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ppp4r4 in Genome Data Viewer
Location:
6q32
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128427884..128518776)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122663172..122753988)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127400585..127497280)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene uncharacterized LOC108351293 Neighboring gene serpin family A member 10 Neighboring gene serpin family A member 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. Chen GI, et al. J Biol Chem, 2008 Oct 24. PMID 18715871, Free PMC Article
  2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein serine/threonine phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein serine/threonine phosphatase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134632.2 → NP_001128104.2  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2JV26
    Related
    ENSRNOP00000069324.2, ENSRNOT00000087429.3

  2. NM_001414974.1 → NP_001401903.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5ZPK8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    128427884..128518776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262336.1 → XP_063118406.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZPK8
    Related
    ENSRNOP00000080384.1, ENSRNOT00000104568.2

  2. XM_063262337.1 → XP_063118407.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X4

  3. XM_063262338.1 → XP_063118408.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X5

  4. XM_039112758.2 → XP_038968686.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ADF5
    Conserved Domains (1) summary
    sd00044
    Location:105 → 135
    HEAT; HEAT repeat [structural motif]

  5. XM_039112759.2 → XP_038968687.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ADF5
    Conserved Domains (1) summary
    sd00044
    Location:105 → 135
    HEAT; HEAT repeat [structural motif]

  6. XM_039112760.2 → XP_038968688.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X3

    Conserved Domains (1) summary
    sd00044
    Location:157 → 185
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools