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Mtbp MDM2 binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 500870, updated on 4-Jan-2025

Summary

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Symbol
Mtbpprovided by RGD
Full Name
MDM2 binding proteinprovided by RGD
Primary source
RGD:1565672
See related
EnsemblRapid:ENSRNOG00000004412 AllianceGenome:RGD:1565672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565672
Summary
Predicted to be involved in protein localization to kinetochore and traversing start control point of mitotic cell cycle. Predicted to act upstream of or within negative regulation of cell population proliferation and negative regulation of mitotic nuclear division. Predicted to be located in chromatin. Predicted to be active in kinetochore. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 40.4), Thymus (RPKM 33.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtbp in Genome Data Viewer
Location:
7q32
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (88862939..88945491)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (86973215..87055775)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (95309928..95392418)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene collagen type XIV alpha 1 chain Neighboring gene eukaryotic translation initiation factor 1, pseudogene 1 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene uncharacterized LOC120093658 Neighboring gene syntrophin, beta 1 Neighboring gene transfer RNA lysine (anticodon CUU) 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MTBP plays a crucial role in mitotic progression and chromosome segregation. Agarwal N, et al. Cell Death Differ, 2011 Jul. PMID 21274008, Free PMC Article
  2. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. Boyd MT, et al. J Biol Chem, 2000 Oct 13. PMID 10906133
  3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in traversing start control point of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within traversing start control point of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mdm2-binding protein
Names
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130717.2 → NP_001124189.2  mdm2-binding protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HRH7, D4AB60
    Related
    ENSRNOP00000005887.5, ENSRNOT00000005887.6
    Conserved Domains (3) summary
    pfam14918
    Location:1 → 270
    MTBP_N; MDM2-binding
    pfam14919
    Location:294 → 633
    MTBP_mid; MDM2-binding
    pfam14920
    Location:637 → 891
    MTBP_C; MDM2-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    88862939..88945491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241656.5 → XP_006241718.1  mdm2-binding protein isoform X2

    See identical proteins and their annotated locations for XP_006241718.1

    UniProtKB/TrEMBL
    A6HRH7, D4AB60
    Related
    ENSRNOP00000100117.1, ENSRNOT00000141688.1
    Conserved Domains (3) summary
    pfam14918
    Location:1 → 270
    MTBP_N; MDM2-binding
    pfam14919
    Location:294 → 633
    MTBP_mid; MDM2-binding
    pfam14920
    Location:637 → 867
    MTBP_C; MDM2-binding

  2. XM_039079751.2 → XP_038935679.1  mdm2-binding protein isoform X3

    UniProtKB/TrEMBL
    A6HRH7, D4AB60
    Conserved Domains (3) summary
    pfam14918
    Location:1 → 270
    MTBP_N; MDM2-binding
    pfam14919
    Location:294 → 633
    MTBP_mid; MDM2-binding
    pfam14920
    Location:637 → 802
    MTBP_C; MDM2-binding

  3. XM_063264120.1 → XP_063120190.1  mdm2-binding protein isoform X1

    UniProtKB/TrEMBL
    A6HRH7, D4AB60

  4. XM_039079754.2 → XP_038935682.2  mdm2-binding protein isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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