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Sh3bgrl2 SH3 domain binding glutamate-rich protein like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501026, updated on 4-Jan-2025

Summary

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Symbol
Sh3bgrl2provided by RGD
Full Name
SH3 domain binding glutamate-rich protein like 2provided by RGD
Primary source
RGD:1591931
See related
EnsemblRapid:ENSRNOG00000009613 AllianceGenome:RGD:1591931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SH3 domain binding activity. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human SH3BGRL2 (SH3 domain binding glutamate rich protein like 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 26.0), Brain (RPKM 18.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh3bgrl2 in Genome Data Viewer
Location:
8q31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (93341104..93433143)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (84461019..84553124)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (91069925..91162537)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479960 Neighboring gene ribosomal protein S18, pseudogene 9 Neighboring gene small nucleolar RNA SNORA32 Neighboring gene uncharacterized LOC108351754

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3 domain-binding glutamic acid-rich-like protein 2
Names
SH3 domain binding glutamic acid-rich protein like 2
SH3 domain-binding glutamic acid-rich-like protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389250.1 → NP_001376179.1  SH3 domain-binding glutamic acid-rich-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K8I0
    Related
    ENSRNOP00000109586.1, ENSRNOT00000156765.1
    Conserved Domains (1) summary
    cd03030
    Location:2 → 97
    GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

  2. NM_001389251.1 → NP_001376180.1  SH3 domain-binding glutamic acid-rich-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6GGG5
    Related
    ENSRNOP00000088668.1, ENSRNOT00000096648.2
    Conserved Domains (1) summary
    cd03030
    Location:2 → 78
    GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    93341104..93433143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081966.2 → XP_038937894.1  SH3 domain-binding glutamic acid-rich-like protein 2 isoform X1

    Conserved Domains (1) summary
    cd03030
    Location:2 → 77
    GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

RNA

  1. XR_010054016.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001137647.1: Suppressed sequence

    Description
    NM_001137647.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version

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