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Poc1a POC1 centriolar protein A [ Rattus norvegicus (Norway rat) ]

Gene ID: 501048, updated on 4-Jan-2025

Summary

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Official Symbol
Poc1aprovided by RGD
Official Full Name
POC1 centriolar protein Aprovided by RGD
Primary source
RGD:1565004
See related
EnsemblRapid:ENSRNOG00000037295 AllianceGenome:RGD:1565004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wdr51a; RGD1565004
Summary
Predicted to be involved in cilium assembly. Predicted to act upstream of or within several processes, including growth plate cartilage chondrocyte development; non-motile cilium assembly; and positive regulation of centrosome duplication. Predicted to be located in centrosome; cytoplasm; and spindle pole. Predicted to be active in centriole and ciliary basal body. Orthologous to human POC1A (POC1 centriolar protein A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 23.6), Testes (RPKM 17.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Poc1a in Genome Data Viewer
Location:
8q32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115801335..115869812)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106922058..106991678)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (114982764..115050844)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene uncharacterized LOC120094254 Neighboring gene toll-like receptor 9 Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene dual specificity phosphatase 7 Neighboring gene aminoacylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice. Geister KA, et al. PLoS Genet, 2015 Oct. PMID 26496357, Free PMC Article
  2. Poc1A and Poc1B act together in human cells to ensure centriole integrity. Venoux M, et al. J Cell Sci, 2013 Jan 1. PMID 23015594, Free PMC Article
  3. Basal body stability and ciliogenesis requires the conserved component Poc1. Pearson CG, et al. J Cell Biol, 2009 Dec 14. PMID 20008567, Free PMC Article
  4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within growth plate cartilage chondrocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
POC1 centriolar protein homolog A
Names
WD repeat domain 51A
WD repeat-containing protein 51A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109296.2 → NP_001102766.2  POC1 centriolar protein homolog A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZQ11, D4ABU4
    Related
    ENSRNOP00000080624.2, ENSRNOT00000096090.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    115801335..115869812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081983.2 → XP_038937911.1  POC1 centriolar protein homolog A isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZQ11
    Related
    ENSRNOP00000079424.2, ENSRNOT00000095943.2
    Conserved Domains (2) summary
    cd00200
    Location:11 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:23 → 59
    7WD40; WD40 repeat [structural motif]

  2. XM_039081982.2 → XP_038937910.1  POC1 centriolar protein homolog A isoform X1

    Related
    ENSRNOP00000038175.8, ENSRNOT00000038166.8
    Conserved Domains (2) summary
    cd00200
    Location:11 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:23 → 59
    7WD40; WD40 repeat [structural motif]

  3. XM_039081985.2 → XP_038937913.1  POC1 centriolar protein homolog A isoform X2

    UniProtKB/TrEMBL
    A6I2Q6
    Conserved Domains (2) summary
    cd00200
    Location:2 → 261
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:26 → 63
    7WD40; WD40 repeat [structural motif]

  4. XM_039081987.2 → XP_038937915.1  POC1 centriolar protein homolog A isoform X2

    UniProtKB/TrEMBL
    A6I2Q6
    Conserved Domains (2) summary
    cd00200
    Location:2 → 261
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:26 → 63
    7WD40; WD40 repeat [structural motif]

  5. XM_039081984.2 → XP_038937912.1  POC1 centriolar protein homolog A isoform X4

    Conserved Domains (2) summary
    cd00200
    Location:4 → 212
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:21 → 56
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_010054017.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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