Rftn1 raftlin lipid raft linker 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rftn1provided by RGD
Official Full Name: raftlin lipid raft linker 1provided by RGD
Primary source: RGD:1563347
See related: EnsemblRapid:ENSRNOG00000011321 AllianceGenome:RGD:1563347
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310777; RGD1563347; 2310015n21rik
Summary: Predicted to enable double-stranded RNA binding activity. Predicted to be involved in several processes, including T cell antigen processing and presentation; antigen receptor-mediated signaling pathway; and positive regulation of growth rate. Predicted to act upstream of or within dsRNA transport; response to exogenous dsRNA; and toll-like receptor 3 signaling pathway. Predicted to be located in endosome; membrane raft; and plasma membrane. Predicted to be part of protein-containing complex. Biomarker of glaucoma. Orthologous to human RFTN1 (raftlin, lipid raft linker 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 136.8), Spleen (RPKM 123.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (18302143..18499819)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (10804611..11002084)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (12740885..12942358)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D9Cebr1 (e-PCR)
- UniSTS:518949

AU049072 (e-PCR)
- UniSTS:145520

D4S1579 (e-PCR), detects polymorphism
- UniSTS:31673

RH142923 (e-PCR)
- UniSTS:232170

AU047623 (e-PCR)
- UniSTS:110325

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dsRNA transport	ISO Inferred from Sequence Orthology more info
involved_in membrane raft assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane raft	ISO Inferred from Sequence Orthology more info
involved_in protein transport into membrane raft	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: raftlin

Names: raft-linking protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.