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Stradb STE20 related adaptor beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 501146, updated on 4-Jan-2025

Summary

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Official Symbol
Stradbprovided by RGD
Official Full Name
STE20 related adaptor betaprovided by RGD
Primary source
RGD:1559449
See related
EnsemblRapid:ENSRNOG00000010728 AllianceGenome:RGD:1559449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Als2cr2; RGD1559449
Summary
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in activation of protein kinase activity and protein export from nucleus. Predicted to act upstream of or within JNK cascade; cell morphogenesis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in aggresome; cytosol; and nucleus. Predicted to be part of serine/threonine protein kinase complex. Orthologous to human STRADB (STE20 related adaptor beta). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 287.0), Kidney (RPKM 204.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stradb in Genome Data Viewer
Location:
9q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67908277..67927224)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60414182..60433084)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65763437..65782513)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene uncharacterized LOC120094796 Neighboring gene trafficking kinesin protein 2 Neighboring gene transfer RNA valine (anticodon AAC) 15 Neighboring gene uncharacterized LOC120094795 Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. Nishigaki K, et al. J Biol Chem, 2003 Apr 11. PMID 12574163
  2. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. Boudeau J, et al. EMBO J, 2003 Oct 1. PMID 14517248, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in aggresome IEA
Inferred from Electronic Annotation
more info
  
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of serine/threonine protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
STE20-related kinase adapter protein beta
Names
STE20-related kinase adaptor beta
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2
polyploidy associated protein kinase PAPK-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109307.2 → NP_001102777.2  STE20-related kinase adapter protein beta

    See identical proteins and their annotated locations for NP_001102777.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AK98, A6IP88, D3ZVH0
    Related
    ENSRNOP00000049160.2, ENSRNOT00000043558.4
    Conserved Domains (2) summary
    smart00220
    Location:58 → 369
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08226
    Location:59 → 386
    PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    67908277..67927224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084089.2 → XP_038940017.1  STE20-related kinase adapter protein beta isoform X1

    UniProtKB/TrEMBL
    A0A8I6AK98
    Conserved Domains (1) summary
    cl21453
    Location:59 → 357
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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