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Pid1 phosphotyrosine interaction domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501174, updated on 9-Dec-2024

Summary

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Official Symbol
Pid1provided by RGD
Official Full Name
phosphotyrosine interaction domain containing 1provided by RGD
Primary source
RGD:1560766
See related
AllianceGenome:RGD:1560766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab1-119; RGD1560766
Summary
Predicted to be involved in several processes, including cellular response to cytokine stimulus; positive regulation of macromolecule biosynthetic process; and regulation of phosphate metabolic process. Predicted to be active in cytoplasm. Orthologous to human PID1 (phosphotyrosine interaction domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Liver (RPKM 223.7), Lung (RPKM 74.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pid1 in Genome Data Viewer
Location:
9q35
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (92732471..92951168, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (85284335..85503035, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (91667748..91683468, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily AK member 27, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480402 Neighboring gene delta/notch-like EGF repeat containing Neighboring gene uncharacterized LOC120094725

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of NYGGF4 knockdown on insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes. Zhang CM, et al. J Bioenerg Biomembr, 2010 Oct. PMID 21080215
  2. Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes. Zhao Y, et al. Mol Cell Biochem, 2010 Jul. PMID 20165904
  3. NYGGF4 homologous gene expression in 3T3-L1 adipocytes: regulation by FFA and adipokines. Zhao YP, et al. Mol Biol Rep, 2010 Oct. PMID 19894142
  4. Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation. Wang B, et al. Gene, 2006 Sep 1. PMID 16815647
  5. Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt. Zhang CM, et al. Acta Pharmacol Sin, 2009 Jan. PMID 19079291, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to fatty acid ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to leptin stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of D-glucose import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of D-glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fat cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of reactive oxygen species metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PTB-containing, cubilin and LRP1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379478.1 → NP_001366407.1  PTB-containing, cubilin and LRP1-interacting protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K8X3
    Conserved Domains (1) summary
    cd13167
    Location:56 → 194
    PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    92732471..92951168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084113.2 → XP_038940041.1  PTB-containing, cubilin and LRP1-interacting protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A692
    Conserved Domains (1) summary
    cd13167
    Location:104 → 242
    PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001110493.2: Suppressed sequence

    Description
    NM_001110493.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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