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Nxf7 nuclear RNA export factor 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501621, updated on 27-Nov-2024

Summary

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Official Symbol
Nxf7provided by RGD
Official Full Name
nuclear RNA export factor 7provided by RGD
Primary source
RGD:1566170
See related
EnsemblRapid:ENSRNOG00000023256 AllianceGenome:RGD:1566170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to act upstream of or within RNA export from nucleus. Predicted to be located in cytoplasm and nuclear envelope. Predicted to be active in nucleus. Orthologous to human NXF2 (nuclear RNA export factor 2); NXF2B (nuclear RNA export factor 2B); and NXF5 (nuclear RNA export factor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 71.7) See more
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Genomic context

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See Nxf7 in Genome Data Viewer
Location:
Xq32
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102828592..102845799, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (98535374..98552562, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (106049075..106066334, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene preferentially expressed antigen in melanoma-like Neighboring gene PRAME like, X-linked 1 Neighboring gene t-complex 11 family, X-linked 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the mouse nuclear export factor (Nxf) family members. Tan W, et al. Nucleic Acids Res, 2005. PMID 16027110, Free PMC Article
  2. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. Jun L, et al. Curr Biol, 2001 Sep 18. PMID 11566096
  3. Molecular cloning and functional characterization of mouse Nxf family gene products. Sasaki M, et al. Genomics, 2005 May. PMID 15820316
  4. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article
  5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC114500

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within poly(A)+ mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear RNA export factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037216.2 → NP_001032293.1  nuclear RNA export factor 7

    See identical proteins and their annotated locations for NP_001032293.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    F7FPN7, Q498M8
    Related
    ENSRNOP00000038474.6, ENSRNOT00000033752.6
    Conserved Domains (5) summary
    smart00804
    Location:549 → 611
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:217 → 259
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:110 → 191
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:258 → 320
    LRR_8; Leucine rich repeat
    cl09109
    Location:380 → 531
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

  2. NM_001434343.1 → NP_001421272.1  nuclear RNA export factor 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  3. NM_001434344.1 → NP_001421273.1  nuclear RNA export factor 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    102828592..102845799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257254.5 → XP_006257316.1  nuclear RNA export factor 7 isoform X1

    UniProtKB/TrEMBL
    F7FPN7, Q498M8
    Conserved Domains (5) summary
    smart00804
    Location:549 → 611
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:217 → 259
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:110 → 191
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:258 → 320
    LRR_8; Leucine rich repeat
    cl09109
    Location:380 → 531
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

  2. XM_039099981.2 → XP_038955909.1  nuclear RNA export factor 7 isoform X1

    UniProtKB/TrEMBL
    F7FPN7, Q498M8
    Conserved Domains (5) summary
    smart00804
    Location:549 → 611
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:217 → 259
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:110 → 191
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:258 → 320
    LRR_8; Leucine rich repeat
    cl09109
    Location:380 → 531
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
Nucleotide Protein Strain
Heading Accession and Version

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