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Aplp1 amyloid beta precursor like protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 502317, updated on 27-Nov-2024

Summary

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Official Symbol
Aplp1provided by RGD
Official Full Name
amyloid beta precursor like protein 1provided by RGD
Primary source
RGD:69257
See related
EnsemblRapid:ENSRNOG00000020851 AllianceGenome:RGD:69257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561211; Aplp1_retired
Summary
Predicted to enable adrenergic receptor binding activity and identical protein binding activity. Predicted to be involved in cellular response to norepinephrine stimulus; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and nervous system development. Predicted to act upstream of or within several processes, including cytosolic mRNA polyadenylation; extracellular matrix organization; and regulation of translation. Predicted to be located in membrane; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human APLP1 (amyloid beta precursor like protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 1626.4) and Kidney (RPKM 53.6) See more
Orthologs
human mouse all
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Genomic context

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See Aplp1 in Genome Data Viewer
Location:
1q21
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94824330..94834705, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85696880..85707215, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88897525..88908750, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane immune signaling adaptor Tyrobp Neighboring gene hematopoietic cell signal transducer Neighboring gene NFKB inhibitor delta Neighboring gene kirre like nephrin family adhesion molecule 2 Neighboring gene NPHS1 adhesion molecule, nephrin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization. Xue Y, et al. Proc Natl Acad Sci U S A, 2011 Sep 27. PMID 21930949, Free PMC Article
  2. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Wasco W, et al. Proc Natl Acad Sci U S A, 1992 Nov 15. PMID 1279693, Free PMC Article
  3. Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase. Weber B, et al. Cell Signal, 2006 Oct. PMID 16531006
  4. APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression. Cousins SL, et al. J Neurochem, 2015 Jun. PMID 25683482
  5. Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Cao Q, et al. Mol Cell Biol, 2005 Dec. PMID 16314516, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-2A adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-2A adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables alpha-2B adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-2B adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables alpha-2C adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-2C adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to norepinephrine stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytosolic mRNA polyadenylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
amyloid beta precursor like protein 1
Names
amyloid beta (A4) precursor-like protein 1
amyloid-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100802.2 → NP_001094272.1  amyloid beta precursor like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001094272.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    B1WBV6, F1LRS5
    Conserved Domains (5) summary
    smart00006
    Location:46 → 211
    A4_EXTRA; amyloid A4
    pfam02177
    Location:55 → 154
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:602 → 641
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:156 → 211
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:289 → 471
    APP_E2; E2 domain of amyloid precursor protein

  2. NM_001399814.1 → NP_001386743.1  amyloid beta precursor like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6J9X4
    Related
    ENSRNOP00000028297.6, ENSRNOT00000028297.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94824330..94834705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088308.2 → XP_038944236.1  amyloid beta precursor like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AD03, F1LRS5
    Related
    ENSRNOP00000092071.2, ENSRNOT00000106909.2
    Conserved Domains (3) summary
    smart00006
    Location:46 → 211
    A4_EXTRA; amyloid A4
    pfam12925
    Location:289 → 471
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:569 → 653
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins
Nucleotide Protein Strain
Heading Accession and Version

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