U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COX7C Cytochrome c oxidase subunit 7C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50246, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
COX7Cprovided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 7Cprovided by FlyBase
Primary source
FLYBASE:FBgn0040773
Locus tag
Dmel_CG2249
See related
AllianceGenome:FB:FBgn0040773
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe3A1; BcDNA:LD14731; CG2249; CoAVIIc; CoVIIc; COX-7C; COXO; Dmel\CG2249; VIIc
Summary
Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Is expressed in adult head. Orthologous to human COX7C (cytochrome c oxidase subunit 7C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See COX7C in Genome Data Viewer
Location:
46D7-46D9; 2-61 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10048353..10050066)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5935858..5937571)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene oysgedart Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44295 Neighboring gene antisense RNA:CR44297 Neighboring gene Cytochrome c oxidase subunit 7C-like Neighboring gene seele Neighboring gene magu

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article
  2. Genetic Reduction of Mitochondria Complex I Subunits is Protective against Cisplatin-Induced Neurotoxicity in Drosophila. Groen CM, et al. J Neurosci, 2022 Feb 2. PMID 34893548, Free PMC Article
  3. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Porcelli D, et al. Mitochondrion, 2010 Aug. PMID 20388558
  4. CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B. Brischigliaro M, et al. EMBO Rep, 2022 Aug 3. PMID 35699132, Free PMC Article
  5. Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO. Zhang F, et al. Mol Biol Cell, 2020 Jul 1. PMID 32374658, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytochrome c oxidase subunit 7C
Names
CG2249-PA
CG2249-PB
CG2249-PC
CG2249-PD
COX7C-PA
COX7C-PB
COX7C-PC
COX7C-PD
anon-fast-evolving-3A1
cytochrome c oxidase VIIc
cytochrome c oxidase polypeptide VIIc
cytochrome c oxidase subunit VIIc
subunit VIIc

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10048353..10050066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299339.1 → NP_001286268.1  cytochrome c oxidase subunit 7C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286268.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JW00
    Conserved Domains (1) summary
    cd00929
    Location:20 → 65
    Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_001299340.1 → NP_001286269.1  cytochrome c oxidase subunit 7C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286269.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JW00
    Conserved Domains (1) summary
    cd00929
    Location:20 → 65
    Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  3. NM_144140.3 → NP_652397.1  cytochrome c oxidase subunit 7C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652397.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JW00
    Related
    FBpp0087484
    Conserved Domains (1) summary
    cd00929
    Location:20 → 65
    Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  4. NM_176118.3 → NP_788298.1  cytochrome c oxidase subunit 7C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788298.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JW00
    Related
    FBpp0087485
    Conserved Domains (1) summary
    cd00929
    Location:20 → 65
    Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JW00 Q7JW00

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous