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Foxj2 forkhead box J2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 502886, updated on 4-Jan-2025

Summary

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Official Symbol
Foxj2provided by RGD
Official Full Name
forkhead box J2provided by RGD
Primary source
RGD:1565101
See related
EnsemblRapid:ENSRNOG00000009000 AllianceGenome:RGD:1565101
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565101
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in several processes, including male meiosis I; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Orthologous to human FOXJ2 (forkhead box J2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 89.6), Lung (RPKM 66.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Foxj2 in Genome Data Viewer
Location:
4q42
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (157718990..157745468)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (156047043..156073540)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (155653446..155679815)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Nanog homeobox Neighboring gene solute carrier family 2 member 3 Neighboring gene complement C3a receptor 1 Neighboring gene ribosomal protein L31, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FOXJ2 expression in rat spinal cord after injury and its role in inflammation. Chen X, et al. J Mol Neurosci, 2012 May. PMID 22246994
  2. FHX.L and FHX.S, two isoforms of the human fork-head factor FHX (FOXJ2) with differential activity. Pérez-Sánchez C, et al. J Mol Biol, 2000 Aug 25. PMID 10966786
  3. FHX, a novel fork head factor with a dual DNA binding specificity. Pérez-Sánchez C, et al. J Biol Chem, 2000 Apr 28. PMID 10777590
  4. MicroRNA-34a targets Forkhead box j2 to modulate differentiation of endothelial progenitor cells in response to shear stress. Cheng BB, et al. J Mol Cell Cardiol, 2014 Sep. PMID 24792364
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Li X, et al. Mol Syst Biol, 2015 Jan 21. PMID 25609649, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FOXJ2 may be involved in the pathophysiology of spinal cord injuries.
    Title: FOXJ2 expression in rat spinal cord after injury and its role in inflammation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in male meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of blood vessel endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
forkhead box protein J2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109352.2 → NP_001102822.1  forkhead box protein J2

    See identical proteins and their annotated locations for NP_001102822.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6ILG0, D3Z992
    Related
    ENSRNOP00000062121.1, ENSRNOT00000065419.4
    Conserved Domains (1) summary
    pfam00250
    Location:66 → 143
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    157718990..157745468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108257.2 → XP_038964185.1  forkhead box protein J2 isoform X2

    Conserved Domains (2) summary
    COG5025
    Location:33 → 153
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cl00061
    Location:105 → 161
    FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins

  2. XM_006237311.5 → XP_006237373.1  forkhead box protein J2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW18
    Related
    ENSRNOP00000069705.1, ENSRNOT00000087883.3
    Conserved Domains (1) summary
    pfam00250
    Location:106 → 183
    Forkhead; Forkhead domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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