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ksh kish [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50363, updated on 9-Dec-2024

Summary

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Official Symbol
kshprovided by FlyBase
Official Full Name
kishprovided by FlyBase
Primary source
FLYBASE:FBgn0040890
Locus tag
Dmel_CG14199
See related
AllianceGenome:FB:FBgn0040890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14199; Dmel\CG14199
Summary
Involved in intracellular transport and protein secretion. Located in Golgi apparatus and endoplasmic reticulum. Orthologous to human TMEM167A (transmembrane protein 167A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ksh in Genome Data Viewer
Location:
18C8-18C8; 1-62 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19494420..19494992, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19388453..19389025, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pacman Neighboring gene antisense RNA:CR44340 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 18 kDa subunit Neighboring gene uncharacterized protein Neighboring gene 6-phosphofructo-2-kinase Neighboring gene Isocitrate dehydrogenase 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking. Portela M, et al. Glia, 2019 Feb. PMID 30506943
  2. Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition. Casas-Tintó S, et al. Nat Commun, 2015 Dec 11. PMID 26658841
  3. Ligand-independent requirements of steroid receptors EcR and USP for cell survival. Mansilla A, et al. Cell Death Differ, 2016 Mar. PMID 26250909, Free PMC Article
  4. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article
  5. Systems genetics of complex traits in Drosophila melanogaster. Ayroles JF, et al. Nat Genet, 2009 Mar. PMID 19234471, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kish
Names
CG14199-PB
ksh-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19494420..19494992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144242.4 → NP_652499.2  kish [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652499.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VWH8
    UniProtKB/TrEMBL
    A0A1B2AJU4
    Conserved Domains (1) summary
    pfam06842
    Location:19 → 44
    DUF1242; Protein of unknown function (DUF1242)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWH8.2 Q9VWH8

Gene LinkOut

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