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hsf4 heat shock transcription factor 4 [ Danio rerio (zebrafish) ]

Gene ID: 503739, updated on 4-Jan-2025

Summary

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Official Symbol
hsf4provided by ZNC
Official Full Name
heat shock transcription factor 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-050306-18
See related
Ensembl:ENSDARG00000013251 AllianceGenome:ZFIN:ZDB-GENE-050306-18
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:113344
Summary
Enables sequence-specific DNA binding activity. Involved in lens fiber cell differentiation and maintenance of lens transparency. Acts upstream of or within several processes, including lens morphogenesis in camera-type eye; positive regulation of deoxyribonuclease activity; and regulation of lens fiber cell differentiation. Predicted to be located in nucleus. Is expressed in eye; lens; and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract and cataract 5 multiple types. Orthologous to human HSF4 (heat shock transcription factor 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See hsf4 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (22738408..22753637, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (22750355..22764800, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene si:dkey-11d18.2 Neighboring gene BCAR1 scaffold protein, Cas family member Neighboring gene nudix hydrolase 21 Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a Neighboring gene uncharacterized LOC108179979 Neighboring gene core-binding factor subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish HSF4: a novel protein that shares features of both HSF1 and HSF4 of mammals. Swan CL, et al. Cell Stress Chaperones, 2012 Sep. PMID 22528049, Free PMC Article
  2. Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens. Cui X, et al. Biochim Biophys Acta Gen Subj, 2020 Mar. PMID 31786107
  3. Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo. Cukrov D, et al. Hum Mol Genet, 2018 Sep 1. PMID 29860495
  4. HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators. Gao M, et al. Cell Death Dis, 2017 Oct 5. PMID 28981088, Free PMC Article
  5. HSF4 regulates DLAD expression and promotes lens de-nucleation. Cui X, et al. Biochim Biophys Acta, 2013 Aug. PMID 23507146

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21(cip1) expression.
    Title: Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21(cip1) expression.
  2. Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish.
    Title: Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish.
  3. In the hsf4(null) fish, both p53 and activated-caspase3 were significantly decreased. Combined with the finding that the denucleation defect could be partially rescued through microinjection of p53, fas and bax mRNA into the mutant embryos, we directly proved that HSF4 promotes lens fiber cell differentiation by activating p53 and its downstream regulators
    Title: HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • BX088710.1

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lens morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of lens transparency IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of deoxyribonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heat shock factor protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328208.1 → NP_001315137.1  heat shock factor protein 4

    Status: VALIDATED

    Source sequence(s)
    BX088710
    UniProtKB/Swiss-Prot
    A0A2R8QAT5, Q5CZP2
    UniProtKB/TrEMBL
    A0A8M9PQ64
    Related
    ENSDARP00000150156.1, ENSDART00000181589.1
    Conserved Domains (2) summary
    smart00415
    Location:17 → 121
    HSF; heat shock factor
    pfam06546
    Location:253 → 409
    Vert_HS_TF; Vertebrate heat shock transcription factor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    22738408..22753637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293553.4 → XP_009291828.1  heat shock factor protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AJJ3
    Conserved Domains (2) summary
    smart00415
    Location:17 → 121
    HSF; heat shock factor
    pfam06546
    Location:253 → 412
    Vert_HS_TF; Vertebrate heat shock transcription factor

  2. XM_021467640.2 → XP_021323315.1  heat shock factor protein 4 isoform X1

    UniProtKB/Swiss-Prot
    A0A2R8QAT5, Q5CZP2
    UniProtKB/TrEMBL
    A0A8M9PQ64
    Conserved Domains (2) summary
    smart00415
    Location:17 → 121
    HSF; heat shock factor
    pfam06546
    Location:253 → 409
    Vert_HS_TF; Vertebrate heat shock transcription factor

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013317.2: Suppressed sequence

    Description
    NM_001013317.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5CZP2.2 GenPept UniProtKB/Swiss-Prot:Q5CZP2

Gene LinkOut

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