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hsf4 - heat shock transcription factor 4

Enables sequence-specific DNA binding activity. Involved in lens fiber cell differentiation and maintenance of lens transparency. Acts upstream of or within several processes, including lens morphogenesis in camera-type eye; positive regulation of deoxyribonuclease activity; and regulation of lens fiber cell differentiation. Predicted to be located in nucleus. Is expressed in eye; lens; and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract and cataract 5 multiple types. Orthologous to human HSF4 (heat shock transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa