a nonagouti [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: aprovided by MGI
Official Full Name: nonagoutiprovided by MGI
Primary source: MGI:MGI:87853
See related: Ensembl:ENSMUSG00000027596 AllianceGenome:MGI:87853
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: As; ASP; A<y>; ASIP
Summary: Enables type 3 melanocortin receptor binding activity and type 4 melanocortin receptor binding activity. Involved in melanin biosynthetic process and positive regulation of melanin biosynthetic process. Acts upstream of or within several processes, including adult feeding behavior; melanosome organization; and melanosome transport. Predicted to be active in extracellular space. Is expressed in forelimb epithelium; hair bulb; hindlimb epithelium; and skin. Used to study abdominal obesity-metabolic syndrome 1; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in pigmentation disease. Orthologous to human ASIP (agouti signaling protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 7.7), limb E14.5 (RPKM 2.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 76.83 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (154792519..154892932)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (154950599..155051012)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of the Combination of the C1473G Mutation in the Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice.
Title: Effects of the Combination of the C1473G Mutation in the Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice.
Phylogeographic study using nuclear genome sequences of Asip to infer the origins of ventral fur color variation in the house mouse Mus musculus.
Title: Phylogeographic study using nuclear genome sequences of Asip to infer the origins of ventral fur color variation in the house mouse Mus musculus.
Increased risk for T cell autoreactivity to ss-cell antigens in the mice expressing the A(vy) obesity-associated gene.
Title: Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the A(vy) obesity-associated gene.
Mice of A(Y)/a and a/a genotypes did not differ in their home cage activity, sleep, food and water consumption, learning ability in the Morris water maze, anxiety in the open field and elevated plus-maze, as well as in the level of monoamines, metabolites and some genes expression in the brain. Fat mass, depressive-like immobility in the forced swim and tail suspension tests were significantly increased in A(Y)/a mice.
Title: On association of the lethal yellow (A(Y)) mutation in the agouti gene with the alterations in mouse brain and behavior.
The data confirm development of obesity and disturbance of lipid metabolism in Ay males. There were no changes in testicular function.
Title: [TESTICULAR FUNCTION AND LIPID METABOLISM IN MALE MICE WITH HEREDITARY PREDISPOSITION TO OBESITY].
Methylation analysis reveals that although most lines display normal methylation at IAP elements in general, the Avy IAP element is essentially unmethylated.
Title: DNA methylation is dispensable for suppression of the agouti viable yellow controlling element in murine embryonic stem cells.
observed variable histone patterns in the 5' long terminal repeat of the viable yellow agouti (A(vy)) metastable epiallele
Title: Variable histone modifications at the A(vy) metastable epiallele.
study shows ASIP-MC1R signaling includes a cAMP-independent pathway through attractin and mahogunin, while the known cAMP-dependent component requires neither attractin nor mahogunin
Title: Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway.
effects of the A(y) allele on mandible morphology on different strain backgrounds, DDD and B6
Title: The Ay allele at the agouti locus reduces the size and alters the shape of the mandible in mice.
pigment-related genes targeted by ASP and by alphaMSH
Title: Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically and radiation induced (1)
Chemically induced (ENU) (10) 1 citation
Chemically induced (other) (5) 1 citation
Endonuclease-mediated (5) 1 citation
Not Applicable (1) 1 citation
Radiation induced (29) 1 citation
Spontaneous (60) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

PMC344181P1 (e-PCR)
- UniSTS:273206

NoName (e-PCR)
- UniSTS:234565

AU021883 (e-PCR)
- UniSTS:167326

a (e-PCR), detects polymorphism
- UniSTS:140990

Raly (e-PCR), detects polymorphism
- UniSTS:144321

L06451 (e-PCR)
- UniSTS:124866

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables melanocortin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 3 melanocortin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 4 melanocortin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult feeding behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within adult feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epigenetic programming in the zygotic pronuclei	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of precursor metabolites and energy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in melanin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within melanin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of melanin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: agouti-signaling protein

Names: agouti coat color protein; agouti signal protein; agouti switch protein; non-agouti

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015770.3 → NP_056585.2 agouti-signaling protein precursor

See identical proteins and their annotated locations for NP_056585.2

Status: VALIDATED

Source sequence(s)

AL805955, L06941

Consensus CDS

CCDS16941.1

UniProtKB/Swiss-Prot

A2ALT3, Q03288, Q80ST0

Related

ENSMUSP00000029123.3, ENSMUST00000029123.3

Conserved Domains (1) summary

smart00792
Location:6 → 127

Agouti; Agouti protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

154792519..154892932

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319110.3 → XP_017174599.2 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
XM_030251859.2 → XP_030107719.1 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
XM_030251860.2 → XP_030107720.1 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
XM_017319112.3 → XP_017174601.2 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
XM_017319115.3 → XP_017174604.2 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
XM_017319117.3 → XP_017174606.2 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
XM_017319120.3 → XP_017174609.2 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
XM_017319119.3 → XP_017174608.2 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
XM_017319121.3 → XP_017174610.2 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
XM_011239689.3 → XP_011237991.1 agouti-signaling protein isoform X2

See identical proteins and their annotated locations for XP_011237991.1

UniProtKB/TrEMBL

A0A510NUK5

Conserved Domains (5) summary

PTZ00368
Location:580 → 630

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

pfam00098
Location:609 → 625

zf-CCHC; Zinc knuckle

pfam00607
Location:383 → 583

Gag_p24; gag gene protein p24 (core nucleocapsid protein)

pfam02337
Location:11 → 89

Gag_p10; Retroviral GAG p10 protein

pfam14787
Location:647 → 681

zf-CCHC_5; GAG-polyprotein viral zinc-finger
XM_011239691.2 → XP_011237993.1 agouti-signaling protein isoform X4

Conserved Domains (1) summary

smart00792
Location:45 → 166

Agouti; Agouti protein
XM_011239690.3 → XP_011237992.1 agouti-signaling protein isoform X3

See identical proteins and their annotated locations for XP_011237992.1

UniProtKB/TrEMBL

Q3TZL0

Conserved Domains (1) summary

pfam00429
Location:12 → 627

TLV_coat; ENV polyprotein (coat polyprotein)
XM_030251858.2 → XP_030107718.1 agouti-signaling protein isoform X1

UniProtKB/TrEMBL

A0A510NUJ7

Conserved Domains (6) summary

cd09273
Location:369 → 490

RNase_HI_RT_Bel; Bel/Pao family of RNase HI in long-term repeat retroelements

pfam00552
Location:722 → 768

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:558 → 668

rve; Integrase core domain

pfam02022
Location:505 → 540

Integrase_Zn; Integrase Zinc binding domain

pfam06817
Location:158 → 222

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:1 → 150

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...