U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ubc ubiquitin C [ Rattus norvegicus (Norway rat) ]

Gene ID: 50522, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Ubcprovided by RGD
Official Full Name
ubiquitin Cprovided by RGD
Primary source
RGD:621244
See related
EnsemblRapid:ENSRNOG00000057823 AllianceGenome:RGD:621244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBC (ubiquitin C). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 29445.0), Kidney (RPKM 24271.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ubc in Genome Data Viewer
Location:
12q15
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (36899673..36905275)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (31239149..31243924)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (36638457..36642734)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transfer RNA aspartic acid (anticodon GUC) 5 Neighboring gene transfer RNA alanine (anticodon UGC) 4 Neighboring gene igE-binding protein-like Neighboring gene scavenger receptor class B, member 1 Neighboring gene uncharacterized LOC134481291

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury. Joshi SK, et al. J Orthop Res, 2014 Jan. PMID 24018537, Free PMC Article
  2. Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. Kwon KJ, et al. J Pineal Res, 2011 Mar. PMID 21073519
  3. Ubiquitination of mammalian Pex5p, the peroxisomal import receptor. Carvalho AF, et al. J Biol Chem, 2007 Oct 26. PMID 17726030
  4. Down-regulating protein kinase C alpha: functional cooperation between the proteasome and the endocytic system. Melnikov S, et al. Cell Signal, 2009 Nov. PMID 19586612
  5. Ubiquitin-dependent down-regulation of the neurokinin-1 receptor. Cottrell GS, et al. J Biol Chem, 2006 Sep 22. PMID 16849335

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
polyubiquitin-C

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399781.1 → NP_001386710.1  polyubiquitin-C isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q3ZBA1, Q63429
    Related
    ENSRNOP00000107356.1, ENSRNOT00000166204.1
    Conserved Domains (2) summary
    cd01803
    Location:77 → 152
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    cl28922
    Location:913 → 941
    Ubl1_cv_Nsp3_N-like; first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins

  2. NM_001399782.1 → NP_001386711.1  polyubiquitin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q3ZBA1, Q63429
    UniProtKB/TrEMBL
    F1LML2

  3. NM_001399783.1 → NP_001386712.1  polyubiquitin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q3ZBA1, Q63429
    UniProtKB/TrEMBL
    F1LML2

  4. NM_001399785.1 → NP_001386714.1  polyubiquitin-C isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q3ZBA1, Q63429
    Related
    ENSRNOP00000074688.3, ENSRNOT00000085692.3

  5. NM_001399786.1 → NP_001386715.1  polyubiquitin-C isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    Q5FWT0

  6. NM_001399787.1 → NP_001386716.1  polyubiquitin-C isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    Q5FWT0

  7. NM_001399788.1 → NP_001386717.1  polyubiquitin-C isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  8. NM_017314.3 → NP_059010.2  polyubiquitin-C isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q3ZBA1, Q63429

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    36899673..36905275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271601.1 → XP_063127671.1  polyubiquitin-C isoform X1

    UniProtKB/Swiss-Prot
    Q3ZBA1, Q63429

  2. XM_039089712.2 → XP_038945640.1  polyubiquitin-C isoform X1

    UniProtKB/Swiss-Prot
    Q3ZBA1, Q63429
    Conserved Domains (2) summary
    cd01803
    Location:77 → 152
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    cl28922
    Location:913 → 941
    Ubl1_cv_Nsp3_N-like; first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001399784.1: Suppressed sequence

    Description
    NM_001399784.1: This RefSeq was removed because it is redundant with another RefSeq (NM_017314.3).
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63429.1 GenPept UniProtKB/Swiss-Prot:Q63429

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous