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Ugt8 UDP glycosyltransferase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50555, updated on 27-Nov-2024

Summary

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Official Symbol
Ugt8provided by RGD
Official Full Name
UDP glycosyltransferase 8provided by RGD
Primary source
RGD:3938
See related
EnsemblRapid:ENSRNOG00000009345 AllianceGenome:RGD:3938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CGalT; Ugt8a
Summary
Enables N-acylsphingosine galactosyltransferase activity and UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in galactosylceramide biosynthetic process and response to immobilization stress. Located in endoplasmic reticulum. Orthologous to human UGT8 (UDP glycosyltransferase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 452.3), Kidney (RPKM 63.4) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Ugt8 in Genome Data Viewer
Location:
2q42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (216938884..217007167, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (214264483..214332769, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (229644373..229718678, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 6 Neighboring gene N-deacetylase and N-sulfotransferase 4 Neighboring gene ribosomal protein L7, pseudogene 17 Neighboring gene zinc finger and BTB domain-containing protein 7B-like Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 9 Neighboring gene uncharacterized LOC108350105 Neighboring gene arylsulfatase family, member J

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Synthesis of non-hydroxy-galactosylceramides and galactosyldiglycerides by hydroxy-ceramide galactosyltransferase. van der Bijl P, et al. Biochem J, 1996 Jul 15. PMID 8713090, Free PMC Article
  2. Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression. Schulte S, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 7694285, Free PMC Article
  3. Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose: ceramide galactosyltransferase. Stahl N, et al. J Neurosci Res, 1994 Jun 1. PMID 7521399
  4. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS. Dupree JL, et al. J Neurosci, 1998 Mar 1. PMID 9464989, Free PMC Article
  5. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Coetzee T, et al. Cell, 1996 Jul 26. PMID 8706126

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acylsphingosine galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylsphingosine galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in galactosylceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactosylceramide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in galactosylceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in myelination TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in paranodal junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to paranode region of axon ISO
Inferred from Sequence Orthology
more info
  
involved_in response to immobilization stress IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Names
UDP galactosyltransferase 8
UDP galactosyltransferase 8A
UDP-galactose-ceramide galactosyltransferase 8
UDP-glucuronosyltransferase 8
ceramide UDP-galactosyltransferase
cerebroside synthase
NP_062149.1
XP_017446541.1
XP_063138484.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019276.3 → NP_062149.1  2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor

    See identical proteins and their annotated locations for NP_062149.1

    Status: VALIDATED

    Source sequence(s)
    BF551096, BG671666, U07683
    UniProtKB/Swiss-Prot
    Q09426
    UniProtKB/TrEMBL
    A6HVK3
    Related
    ENSRNOP00000012676.2, ENSRNOT00000012676.6
    Conserved Domains (2) summary
    PHA03392
    Location:8 → 490
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:21 → 502
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    216938884..217007167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591052.3 → XP_017446541.1  2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q09426
    UniProtKB/TrEMBL
    A6HVK3
    Conserved Domains (2) summary
    PHA03392
    Location:8 → 490
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:21 → 502
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

  2. XM_063282414.1 → XP_063138484.1  2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q09426
    UniProtKB/TrEMBL
    A6HVK3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09426.1 GenPept UniProtKB/Swiss-Prot:Q09426

Gene LinkOut

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