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KDSR 3-ketodihydrosphingosine reductase [ Bos taurus (domestic cattle) ]

Gene ID: 505558, updated on 29-Jan-2025

Summary

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Official Symbol
KDSRprovided by VGNC
Official Full Name
3-ketodihydrosphingosine reductaseprovided by VGNC
Primary source
VGNC:VGNC:30536
See related
BGD:BT11724; Ensembl:ENSBTAG00000007723
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
FVT1
Orthologs
human mouse all
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Genomic context

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See KDSR in Genome Data Viewer
Location:
chromosome: 24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (61596090..61638772, complement)

Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene PH domain and leucine rich repeat protein phosphatase 1 Neighboring gene uncharacterized LOC112444194 Neighboring gene BCL2 apoptosis regulator Neighboring gene U6 spliceosomal RNA Neighboring gene vacuolar protein sorting 4 homolog B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy. Krebs S, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17420465, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. G-to-A missense mutation in FVT1, encoding 3-ketodihydrosphingosine reductase, is a strong candidate for causality of spinal muscular atrophy in cattle.
    Title: A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC137214

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3-dehydrosphinganine reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3-keto-sphinganine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sphingolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
3-ketodihydrosphingosine reductase
Names
3-dehydrosphinganine reductase
FVT-1
KDS reductase
follicular lymphoma variant translocation 1
follicular variant translocation protein 1 homolog
NP_001039384.1
XP_024839964.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045919.1 → NP_001039384.1  3-ketodihydrosphingosine reductase precursor

    See identical proteins and their annotated locations for NP_001039384.1

    Status: PROVISIONAL

    Source sequence(s)
    BC112615
    UniProtKB/TrEMBL
    A0AAA9TJW9
    Related
    ENSBTAP00070030344.1, ENSBTAT00070050826.1
    Conserved Domains (2) summary
    cd08939
    Location:32 → 267
    KDSR-like_SDR_c; 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR
    pfam00106
    Location:34 → 232
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    61596090..61638772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024984196.2 → XP_024839964.1  3-ketodihydrosphingosine reductase isoform X1

    UniProtKB/TrEMBL
    A0AAA9TYJ7
    Related
    ENSBTAP00070030350.1, ENSBTAT00070050835.1
    Conserved Domains (1) summary
    cl25409
    Location:32 → 204
    SDR; Short-chain dehydrogenases/reductases (SDR)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KIJ5.2 GenPept UniProtKB/Swiss-Prot:Q2KIJ5

Gene LinkOut

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