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PAK3 p21 (RAC1) activated kinase 3 [ Homo sapiens (human) ]

Gene ID: 5063, updated on 27-Nov-2024

Summary

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Official Symbol
PAK3provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 3provided by HGNC
Primary source
HGNC:HGNC:8592
See related
Ensembl:ENSG00000077264 MIM:300142; AllianceGenome:HGNC:8592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; XLID30; PAK3beta; beta-PAK
Summary
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
Expression
Biased expression in brain (RPKM 8.0), pancreas (RPKM 3.0) and 11 other tissues See more
Orthologs
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Genomic context

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See PAK3 in Genome Data Viewer
Location:
Xq23
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (110944397..111227361)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (109392559..109675560)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (110187625..110470589)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:109911493-109912258 Neighboring gene M6PR pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29856 Neighboring gene chordin like 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110065211-110065764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:110187999-110188834 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110207796-110208396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110254037-110254537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29857 Neighboring gene NANOG hESC enhancer GRCh37_chrX:110438658-110439159 Neighboring gene FCF1 pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:110489468-110490667 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:110498437-110498970 Neighboring gene glutamate dehydrogenase 1 pseudogene 9 Neighboring gene calpain 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PAK signalling in neuronal physiology. Kreis P, et al. Cell Signal, 2009 Mar. PMID 19036346
  2. X-linked mild non-syndromic mental retardation with neuropsychiatric problems and the missense mutation A365E in PAK3. Gedeon AK, et al. Am J Med Genet A, 2003 Aug 1. PMID 12884430
  3. A comparative expression analysis of four MRX genes regulating intracellular signalling via small GTPases. Kohn M, et al. Eur J Hum Genet, 2004 Jan. PMID 14673471
  4. Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. Feng Q, et al. J Biol Chem, 2002 Feb 15. PMID 11741931
  5. PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Zhao ZS, et al. Biochem J, 2005 Mar 1. PMID 15548136, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy.
    Title: PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy.
  2. Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
    Title: Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
  3. PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.
    Title: PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.
  4. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.
    Title: The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.
  5. Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.
    Title: Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.
  6. Prognostic significance of PAK family kinases in acute myeloid leukemia.
    Title: Prognostic significance of PAK family kinases in acute myeloid leukemia.
  7. PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.
    Title: PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.
  8. Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.
    Title: Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.
  9. Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature.
    Title: Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature.
  10. Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.
    Title: Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual disability, X-linked 30
MedGen: C0796237 OMIM: 300558 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686E11117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendritic spine morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in synapse organization TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 3
Names
adriamycin resistance-associated
oligophrenin-3
p21 (CDKN1A)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
NP_001121638.1
NP_001121639.1
NP_001121640.1
NP_001121644.1
NP_001121645.1
NP_001311254.1
NP_001311255.1
NP_001311256.1
NP_001311257.1
NP_001311258.1
NP_001311259.1
NP_001311260.1
NP_001311261.1
NP_001311262.1
NP_001311263.1
NP_002569.1
XP_005262189.1
XP_005262190.1
XP_006724717.1
XP_006724718.1
XP_011529264.1
XP_011529270.1
XP_011529271.1
XP_011529273.1
XP_016885046.1
XP_016885047.1
XP_016885048.1
XP_016885049.1
XP_016885052.1
XP_047298102.1
XP_047298103.1
XP_047298104.1
XP_047298105.1
XP_047298106.1
XP_054183121.1
XP_054183122.1
XP_054183123.1
XP_054183124.1
XP_054183125.1
XP_054183126.1
XP_054183127.1
XP_054183128.1
XP_054183129.1
XP_054183130.1
XP_054183131.1
XP_054183132.1
XP_054183133.1
XP_054183134.1
XP_054183135.1
XP_054183136.1
XP_054183137.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008288.2 RefSeqGene

    Range
    156907..288077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128166.3 → NP_001121638.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_001121638.1

    Status: REVIEWED

    Source sequence(s)
    AK290504, AK315284, AL031117, BC117353, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000410853.1, ENST00000446737.5
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  2. NM_001128167.3 → NP_001121639.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_001121639.1

    Status: REVIEWED

    Source sequence(s)
    AK290504, AL031117, BC117353, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000401982.1, ENST00000425146.5
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  3. NM_001128168.3 → NP_001121640.1  serine/threonine-protein kinase PAK 3 isoform b

    See identical proteins and their annotated locations for NP_001121640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and contains two alternate in-frame exons compared to variant 1. The encoded isoform (b, also known as ab) is longer than isoform a.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48151.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  4. NM_001128172.2 → NP_001121644.1  serine/threonine-protein kinase PAK 3 isoform c

    See identical proteins and their annotated locations for NP_001121644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter 5' UTR and contains an alternate in-frame exon compared to variant 1. It encodes isoform c which is longer than isoform a.
    Source sequence(s)
    AK290504, AL031117, AM943852, BC117353, DB563607
    Consensus CDS
    CCDS48152.1
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000389172.1, ENST00000417227.5
    Conserved Domains (2) summary
    cd06656
    Location:269 → 565
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 147
    PBD; P21-Rho-binding domain

  5. NM_001128173.3 → NP_001121645.1  serine/threonine-protein kinase PAK 3 isoform d

    See identical proteins and their annotated locations for NP_001121645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and contains alternate in-frame exon compared to variant 1. It encodes isoform d (also known as b) which is longer than isoform a.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  6. NM_001324325.2 → NP_001311254.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031117, AL117326, AL356578, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  7. NM_001324326.2 → NP_001311255.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  8. NM_001324327.2 → NP_001311256.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  9. NM_001324328.2 → NP_001311257.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000262836.4, ENST00000262836.6
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  10. NM_001324329.2 → NP_001311258.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000361080.1, ENST00000372010.5
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  11. NM_001324330.2 → NP_001311259.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031117, AL117326, AL356578, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  12. NM_001324331.2 → NP_001311260.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  13. NM_001324332.2 → NP_001311261.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  14. NM_001324333.2 → NP_001311262.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  15. NM_001324334.2 → NP_001311263.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  16. NM_002578.5 → NP_002569.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_002569.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AK290504, AL031117, BC117353, DA022842, DA957724, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000361077.4, ENST00000372007.10
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

RNA

  1. NR_136740.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774

  2. NR_136741.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774

  3. NR_136742.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774

  4. NR_136743.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774

  5. NR_136744.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774

  6. NR_136745.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774

  7. NR_136746.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774

  8. NR_136747.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) represents use of an alternate promoter and contains an alternate exon in the 3' region compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774

  9. NR_136748.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is shorter at the 5' end and contains an alternate exon in the 3' region compared to variant 1.
    Source sequence(s)
    AL031117, AL357774, BC143544

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    110944397..111227361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442148.1 → XP_047298104.1  serine/threonine-protein kinase PAK 3 isoform X4

  2. XM_047442149.1 → XP_047298105.1  serine/threonine-protein kinase PAK 3 isoform X4

  3. XM_017029557.2 → XP_016885046.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  4. XM_011530968.3 → XP_011529270.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529270.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283 → 530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275 → 530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 139
    PBD; P21-Rho-binding domain

  5. XM_011530969.2 → XP_011529271.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529271.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283 → 530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275 → 530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 139
    PBD; P21-Rho-binding domain

  6. XM_017029559.2 → XP_016885048.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:268 → 515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260 → 515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 124
    PBD; P21-Rho-binding domain

  7. XM_017029563.2 → XP_016885052.1  serine/threonine-protein kinase PAK 3 isoform X7

    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000428921.1, ENST00000518291.6
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  8. XM_047442147.1 → XP_047298103.1  serine/threonine-protein kinase PAK 3 isoform X3

  9. XM_011530962.2 → XP_011529264.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529264.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283 → 530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275 → 530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 139
    PBD; P21-Rho-binding domain

  10. XM_047442146.1 → XP_047298102.1  serine/threonine-protein kinase PAK 3 isoform X3

  11. XM_005262132.3 → XP_005262189.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_005262189.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283 → 530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275 → 530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 139
    PBD; P21-Rho-binding domain

  12. XM_005262133.4 → XP_005262190.1  serine/threonine-protein kinase PAK 3 isoform X3

    See identical proteins and their annotated locations for XP_005262190.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:268 → 515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260 → 515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 124
    PBD; P21-Rho-binding domain

  13. XM_006724654.3 → XP_006724717.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_006724717.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283 → 530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275 → 530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 139
    PBD; P21-Rho-binding domain

  14. XM_017029558.2 → XP_016885047.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:268 → 515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260 → 515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 124
    PBD; P21-Rho-binding domain

  15. XM_006724655.3 → XP_006724718.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_006724718.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283 → 530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275 → 530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 139
    PBD; P21-Rho-binding domain

  16. XM_017029560.2 → XP_016885049.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:268 → 515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260 → 515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 124
    PBD; P21-Rho-binding domain

  17. XM_011530971.3 → XP_011529273.1  serine/threonine-protein kinase PAK 3 isoform X6

    Conserved Domains (2) summary
    pfam00786
    Location:69 → 139
    PBD; P21-Rho-binding domain
    cl21453
    Location:262 → 292
    PKc_like; Protein Kinases, catalytic domain

  18. XM_047442150.1 → XP_047298106.1  serine/threonine-protein kinase PAK 3 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    109392559..109675560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327159.1 → XP_054183134.1  serine/threonine-protein kinase PAK 3 isoform X4

  2. XM_054327160.1 → XP_054183135.1  serine/threonine-protein kinase PAK 3 isoform X4

  3. XM_054327152.1 → XP_054183127.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8

  4. XM_054327151.1 → XP_054183126.1  serine/threonine-protein kinase PAK 3 isoform X1

  5. XM_054327150.1 → XP_054183125.1  serine/threonine-protein kinase PAK 3 isoform X1

  6. XM_054327156.1 → XP_054183131.1  serine/threonine-protein kinase PAK 3 isoform X3

  7. XM_054327162.1 → XP_054183137.1  serine/threonine-protein kinase PAK 3 isoform X7

  8. XM_054327158.1 → XP_054183133.1  serine/threonine-protein kinase PAK 3 isoform X3

  9. XM_054327149.1 → XP_054183124.1  serine/threonine-protein kinase PAK 3 isoform X1

  10. XM_054327154.1 → XP_054183129.1  serine/threonine-protein kinase PAK 3 isoform X3

  11. XM_054327146.1 → XP_054183121.1  serine/threonine-protein kinase PAK 3 isoform X1

  12. XM_054327153.1 → XP_054183128.1  serine/threonine-protein kinase PAK 3 isoform X3

  13. XM_054327147.1 → XP_054183122.1  serine/threonine-protein kinase PAK 3 isoform X1

  14. XM_054327155.1 → XP_054183130.1  serine/threonine-protein kinase PAK 3 isoform X3

  15. XM_054327148.1 → XP_054183123.1  serine/threonine-protein kinase PAK 3 isoform X1

  16. XM_054327157.1 → XP_054183132.1  serine/threonine-protein kinase PAK 3 isoform X3

  17. XM_054327161.1 → XP_054183136.1  serine/threonine-protein kinase PAK 3 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75914.2 GenPept UniProtKB/Swiss-Prot:O75914

Gene LinkOut

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