Myl12b myosin light chain 12B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myl12bprovided by RGD
Official Full Name: myosin light chain 12Bprovided by RGD
Primary source: RGD:628855
See related: EnsemblRapid:ENSRNOG00000091388 AllianceGenome:RGD:628855
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrlc2; Mrlcb; Mylc2b
Summary: Predicted to enable GTPase binding activity; calcium ion binding activity; and myosin heavy chain binding activity. Predicted to act upstream of or within regulation of cell shape. Part of protein-containing complex. Orthologous to several human genes including MYL12B (myosin light chain 12B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 809.6), Heart (RPKM 610.4) and 9 other tissues See more
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Genomic context

Location:: 9q38

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (118320479..118334810, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (110873855..110888187, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (119307168..119321500, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of myosin regulatory light chain (RLC) increased and remained elevated post-MI, while phosphorylation of myosin binding protein-C (MyBP-C) was initially depressed but then increased as the hearts became decompensated.
Title: A post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylation.
Findings conclude that phosphorylation at Thr(18) decreases the rates of LC(20) dephosphorylation and smooth muscle relaxation compared with LC(20) phosphorylated exclusively at Ser(19).
Title: Myosin regulatory light chain diphosphorylation slows relaxation of arterial smooth muscle.
role of myosin regulatory light chain phosphorylation by myosin light chain kinase (MLCK) in regulating the invasiveness of metastatic cancer cells
Title: Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain.
drebrin-A may affect spine dynamics, vesicle transport, and other myosin-V-driven motility in neurons through attenuating the interaction between actin and myosin-V
Title: Drebrin attenuates the interaction between actin and myosin-V.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables myosin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin heavy chain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin regulatory light chain 12B

Names: MLC-2; MLC20; myosin RLC-B; myosin light chain, regulatory B; myosin regulatory light chain 20 kDa; myosin regulatory light chain MRLC2; myosin regulatory light chain-B; myosin, light chain 12B, regulatory

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017343.2 → NP_059039.2 myosin regulatory light chain 12B

See identical proteins and their annotated locations for NP_059039.2

Status: VALIDATED

Source sequence(s)

BC060577, CF977112, CO405920, EV769828

UniProtKB/Swiss-Prot

P18666, Q6P9V4

UniProtKB/TrEMBL

A6KF93

Related

ENSRNOP00000045992.5, ENSRNOT00000048125.6

Conserved Domains (1) summary

COG5126
Location:19 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

118320479..118334810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084137.2 → XP_038940065.1 myosin regulatory light chain 12B isoform X1

UniProtKB/Swiss-Prot

P18666, Q6P9V4

UniProtKB/TrEMBL

A6KF93

Conserved Domains (1) summary

COG5126
Location:19 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]