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Myadm myeloid-associated differentiation marker [ Mus musculus (house mouse) ]

Gene ID: 50918, updated on 27-Nov-2024

Summary

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Official Symbol
Myadmprovided by MGI
Official Full Name
myeloid-associated differentiation markerprovided by MGI
Primary source
MGI:MGI:1355332
See related
Ensembl:ENSMUSG00000068566 AllianceGenome:MGI:1355332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D7Wsu62e
Summary
Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; negative regulation of protein kinase C signaling; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in cortical actin cytoskeleton; membrane raft; and ruffle. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in several structures, including immune system; intestine smooth muscle circular layer; limb; liver; and lung. Orthologous to human MYADM (myeloid associated differentiation marker). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 144.9), subcutaneous fat pad adult (RPKM 132.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Myadm in Genome Data Viewer
Location:
7 A1; 7 1.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3337563..3347871)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3289038..3299355)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17893 Neighboring gene olfactory receptor GA_x5J8B7W3939-136239-135295 Neighboring gene STARR-positive B cell enhancer ABC_E10422 Neighboring gene acidic ribosomal phosphoprotein P0 pseudogene Neighboring gene protein kinase C, gamma Neighboring gene STARR-seq mESC enhancer starr_17899 Neighboring gene calcium channel, voltage-dependent, gamma subunit 7 Neighboring gene STARR-seq mESC enhancer starr_17900

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the mouse myeloid-associated differentiation marker (MYADM) gene: promoter analysis and protein localization. Dannaeus K, et al. Mol Biol Rep, 2005 Sep. PMID 16172915
  2. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Dy ABC, et al. Sci Rep, 2021 Dec 3. PMID 34862427, Free PMC Article
  3. Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation. Pettersson M, et al. J Leukoc Biol, 2000 Mar. PMID 10733104
  4. Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability. Wang J, et al. Hypertension, 2024 Aug. PMID 38832511
  5. Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Horie K, et al. Mol Cell Biol, 2003 Dec. PMID 14645530, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability.
    Title: Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability.
  2. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity.
    Title: Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity.
  3. Functional analysis of the promotor region of the MYADM gene.
    Title: Characterization of the mouse myeloid-associated differentiation marker (MYADM) gene: promoter analysis and protein localization.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation
  • Transposon induced (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane raft organization IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane raft organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane raft IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane raft ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myeloid-associated differentiation marker
Names
myeloid up-regulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093764.1 → NP_001087233.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001087233.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI842980, AK052258, BY163724, CJ156102, CK782239
    Consensus CDS
    CCDS51964.1
    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Related
    ENSMUSP00000144984.2, ENSMUST00000203328.4
    Conserved Domains (1) summary
    pfam01284
    Location:39 → 146
    MARVEL; Membrane-associating domain

  2. NM_001093765.1 → NP_001087234.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001087234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI842980, AK052258, BY252968, BY767460
    Consensus CDS
    CCDS51964.1
    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Related
    ENSMUSP00000145120.2, ENSMUST00000203566.3
    Conserved Domains (1) summary
    pfam01284
    Location:39 → 146
    MARVEL; Membrane-associating domain

  3. NM_001093766.1 → NP_001087235.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001087235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI842980, AK052258, CF166357
    Consensus CDS
    CCDS51964.1
    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Related
    ENSMUSP00000131318.2, ENSMUST00000164553.8
    Conserved Domains (1) summary
    pfam01284
    Location:39 → 146
    MARVEL; Membrane-associating domain

  4. NM_016969.2 → NP_058665.2  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_058665.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI842980, AK052258, AK089538, BY060170
    Consensus CDS
    CCDS51964.1
    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Related
    ENSMUSP00000094505.6, ENSMUST00000096744.8
    Conserved Domains (1) summary
    pfam01284
    Location:39 → 146
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3337563..3347871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540171.5 → XP_006540234.1  myeloid-associated differentiation marker isoform X1

    See identical proteins and their annotated locations for XP_006540234.1

    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Conserved Domains (1) summary
    pfam01284
    Location:39 → 146
    MARVEL; Membrane-associating domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35682.2 GenPept UniProtKB/Swiss-Prot:O35682

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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