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PCM1 pericentriolar material 1 [ Homo sapiens (human) ]

Gene ID: 5108, updated on 27-Nov-2024

Summary

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Official Symbol
PCM1provided by HGNC
Official Full Name
pericentriolar material 1provided by HGNC
Primary source
HGNC:HGNC:8727
See related
Ensembl:ENSG00000078674 MIM:600299; AllianceGenome:HGNC:8727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTC4; RET/PCM-1
Summary
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Broad expression in testis (RPKM 47.5), thyroid (RPKM 18.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See PCM1 in Genome Data Viewer
Location:
8p22
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (17922988..18029948)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (18190478..18297432)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17780497..17887457)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene fibrinogen like 1 Neighboring gene endogenous retrovirus group K member 25 Env polyprotein-like Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:17769002-17769792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17769793-17770581 Neighboring gene Sharpr-MPRA regulatory region 2266 Neighboring gene uncharacterized LOC124901867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27048 Neighboring gene Sharpr-MPRA regulatory region 9839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27050 Neighboring gene uncharacterized LOC124901894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:17911125-17911698 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17942063-17942598 Neighboring gene ASAH1 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mapping of the human autoantigen pericentriolar material 1 (PCM1) gene to chromosome 8p21.3-p22. Ohata H, et al. Genomics, 1994 Nov 15. PMID 7698772
  2. Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia. Gurling HM, et al. Arch Gen Psychiatry, 2006 Aug. PMID 16894060, Free PMC Article
  3. Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. Srsen V, et al. J Cell Biol, 2006 Aug 28. PMID 16943179, Free PMC Article
  4. Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers. Armes JE, et al. Oncogene, 2004 Jul 22. PMID 15184884
  5. A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia. Datta SR, et al. Mol Psychiatry, 2010 Jun. PMID 19048012

See all (196) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA-ENST00000421645 promotes T cells to secrete IFN-gamma by sponging PCM1 in neurosyphilis.
    Title: LncRNA-ENST00000421645 promotes T cells to secrete IFN-γ by sponging PCM1 in neurosyphilis.
  2. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
    Title: PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
  3. SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis.
    Title: SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis.
  4. study reveals that USP9X is a constituent of centriolar satellites and functions to maintain centriolar satellite integrity by stabilizing PCM1.
    Title: Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.
  5. detecting PDGFRA, PDGFRB, FGFR1 and PCM1-JAK2 rearrangements is a prerequisite for up-to-date WHO classification, and an essential step in the differential diagnosis of neoplasms with eosinophilia.
    Title: Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2.
  6. In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly.
    Title: Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis.
  7. Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein)
    Title: The X-linked deubiquitinase USP9X is an integral component of centrosome.
  8. a novel variant in the PCM1 3'UTR is significantly associated with ovarian cancer
    Title: Targeted resequencing of the microRNAome and 3'UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer.
  9. no association between the PCM1 gene and schizophrenia in a Japanese population
    Title: Four polymorphisms of the pericentriolar material 1 (PCM1) gene are not associated with schizophrenia in a Japanese population.
  10. Haematological neoplasms associated with t(8;9)(p22;p24); PCM1-JAK2 have features in common and we suggest that they should be recognized as a specific entity in the WHO classification
    Title: Should myeloid and lymphoid neoplasms with PCM1-JAK2 and other rearrangements of JAK2 be recognized as specific entities?
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interkinetic nuclear migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intraciliary transport involved in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule anchoring ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein-containing complex localization to centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein complex stability IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in social behavior IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
  
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
NOT located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in pericentriolar material ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pericentriolar material 1 protein
Names
PCM-1
hPCM-1
pericentriolar material 1, PCM1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027690.2 RefSeqGene

    Range
    5002..111962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001315507.2 → NP_001302436.2  pericentriolar material 1 protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS83256.1
    UniProtKB/TrEMBL
    A0A5H1ZRS1, B9EIS5
    Related
    ENSP00000431099.1, ENST00000519253.5
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1372 → 1990
    PCM1_C; Pericentriolar material 1 C-terminus

  2. NM_001315508.2 → NP_001302437.2  pericentriolar material 1 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame segments compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS83255.1
    UniProtKB/TrEMBL
    A0A4W8VX11, A2RUU9
    Related
    ENSP00000430521.1, ENST00000524226.5
    Conserved Domains (1) summary
    pfam15717
    Location:1318 → 1834
    PCM1_C; Pericentriolar material 1 C-terminus

  3. NM_001352632.2 → NP_001339561.2  pericentriolar material 1 protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1411 → 2041
    PCM1_C; Pericentriolar material 1 C-terminus

  4. NM_001352633.2 → NP_001339562.2  pericentriolar material 1 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1418 → 2036
    PCM1_C; Pericentriolar material 1 C-terminus

  5. NM_001352634.2 → NP_001339563.2  pericentriolar material 1 protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1372 → 2002
    PCM1_C; Pericentriolar material 1 C-terminus

  6. NM_001352635.2 → NP_001339564.2  pericentriolar material 1 protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1373 → 1991
    PCM1_C; Pericentriolar material 1 C-terminus

  7. NM_001352636.2 → NP_001339565.2  pericentriolar material 1 protein isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1357 → 1983
    PCM1_C; Pericentriolar material 1 C-terminus

  8. NM_001352637.2 → NP_001339566.2  pericentriolar material 1 protein isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1356 → 1982
    PCM1_C; Pericentriolar material 1 C-terminus

  9. NM_001352638.2 → NP_001339567.2  pericentriolar material 1 protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1356 → 1974
    PCM1_C; Pericentriolar material 1 C-terminus

  10. NM_001352639.2 → NP_001339568.2  pericentriolar material 1 protein isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1947
    PCM1_C; Pericentriolar material 1 C-terminus

  11. NM_001352640.2 → NP_001339569.2  pericentriolar material 1 protein isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1318 → 1944
    PCM1_C; Pericentriolar material 1 C-terminus

  12. NM_001352641.2 → NP_001339570.2  pericentriolar material 1 protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1939
    PCM1_C; Pericentriolar material 1 C-terminus

  13. NM_001352642.2 → NP_001339571.2  pericentriolar material 1 protein isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    A2RUU9
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1833
    PCM1_C; Pericentriolar material 1 C-terminus

  14. NM_001352643.2 → NP_001339572.2  pericentriolar material 1 protein isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1411 → 1509
    PCM1_C; Pericentriolar material 1 C-terminus

  15. NM_001352644.2 → NP_001339573.2  pericentriolar material 1 protein isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform 16.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1943
    PCM1_C; Pericentriolar material 1 C-terminus

  16. NM_001352645.2 → NP_001339574.2  pericentriolar material 1 protein isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform 16.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1943
    PCM1_C; Pericentriolar material 1 C-terminus

  17. NM_001352646.2 → NP_001339575.2  pericentriolar material 1 protein isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform 17.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1935
    PCM1_C; Pericentriolar material 1 C-terminus

  18. NM_001352647.2 → NP_001339576.2  pericentriolar material 1 protein isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform 17.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1935
    PCM1_C; Pericentriolar material 1 C-terminus

  19. NM_001352648.2 → NP_001339577.2  pericentriolar material 1 protein isoform 18

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform 18.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1318 → 1936
    PCM1_C; Pericentriolar material 1 C-terminus

  20. NM_001352649.2 → NP_001339578.2  pericentriolar material 1 protein isoform 18

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform 18.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    B9EIS5
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1318 → 1936
    PCM1_C; Pericentriolar material 1 C-terminus

  21. NM_001352650.2 → NP_001339579.2  pericentriolar material 1 protein isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variant 23, encodes isoform 19.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1411 → 2037
    PCM1_C; Pericentriolar material 1 C-terminus

  22. NM_001352651.2 → NP_001339580.2  pericentriolar material 1 protein isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variant 22, encodes isoform 19.
    Source sequence(s)
    AC087273, AC087625
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1411 → 2037
    PCM1_C; Pericentriolar material 1 C-terminus

  23. NM_001352652.2 → NP_001339581.2  pericentriolar material 1 protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 24, and 25 encode isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS47812.1
    UniProtKB/Swiss-Prot
    A6NNN6, B4DYD5, E7ETA6, E7EV56, Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1372 → 1998
    PCM1_C; Pericentriolar material 1 C-terminus

  24. NM_001352653.2 → NP_001339582.2  pericentriolar material 1 protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 24, and 25 encode isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS47812.1
    UniProtKB/Swiss-Prot
    A6NNN6, B4DYD5, E7ETA6, E7EV56, Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2
    UniProtKB/TrEMBL
    H0YBA1
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1372 → 1998
    PCM1_C; Pericentriolar material 1 C-terminus

  25. NM_001352654.2 → NP_001339583.2  pericentriolar material 1 protein isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 27 and 28, encodes isoform 21.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 447
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1415
    PCM1_C; Pericentriolar material 1 C-terminus

  26. NM_001352655.2 → NP_001339584.2  pericentriolar material 1 protein isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 26 and 28, encodes isoform 21.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 447
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1415
    PCM1_C; Pericentriolar material 1 C-terminus

  27. NM_001352656.2 → NP_001339585.2  pericentriolar material 1 protein isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 26 and 27, encodes isoform 21.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 447
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1317 → 1415
    PCM1_C; Pericentriolar material 1 C-terminus

  28. NM_001352657.2 → NP_001339586.2  pericentriolar material 1 protein isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variant 30, encodes isoform 22.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1372 → 1470
    PCM1_C; Pericentriolar material 1 C-terminus

  29. NM_001352658.2 → NP_001339587.2  pericentriolar material 1 protein isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variant 29, encodes isoform 22.
    Source sequence(s)
    AC087273, AC087625
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1372 → 1470
    PCM1_C; Pericentriolar material 1 C-terminus

  30. NM_001352659.2 → NP_001339588.2  pericentriolar material 1 protein isoform 23

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variant 32, encodes isoform 23.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS87582.1
    UniProtKB/TrEMBL
    E9PGW9
    Related
    ENSP00000428123.1, ENST00000518537.5
    Conserved Domains (1) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  31. NM_001352660.2 → NP_001339589.2  pericentriolar material 1 protein isoform 23

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variant 31, encodes isoform 23.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS87582.1
    UniProtKB/TrEMBL
    E9PGW9
    Conserved Domains (1) summary
    COG1196
    Location:226 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  32. NM_006197.4 → NP_006188.4  pericentriolar material 1 protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 24, and 25 encode isoform 1.
    Source sequence(s)
    AC087273, AC087625
    Consensus CDS
    CCDS47812.1
    UniProtKB/Swiss-Prot
    A6NNN6, B4DYD5, E7ETA6, E7EV56, Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2
    UniProtKB/TrEMBL
    H0YBA1
    Related
    ENSP00000327077.8, ENST00000325083.13
    Conserved Domains (2) summary
    TIGR02302
    Location:231 → 450
    aProt_lowcomp; TIGR02302 family protein
    pfam15717
    Location:1372 → 1998
    PCM1_C; Pericentriolar material 1 C-terminus

RNA

  1. NR_148032.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    17922988..18029948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    18190478..18297432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15154.6 GenPept UniProtKB/Swiss-Prot:Q15154

Gene LinkOut

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