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SIRT7 sirtuin 7 [ Homo sapiens (human) ]

Gene ID: 51547, updated on 27-Nov-2024

Summary

Official Symbol
SIRT7provided by HGNC
Official Full Name
sirtuin 7provided by HGNC
Primary source
HGNC:HGNC:14935
See related
Ensembl:ENSG00000187531 MIM:606212; AllianceGenome:HGNC:14935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L7
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 8.5), bone marrow (RPKM 8.5) and 25 other tissues See more
Orthologs
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Genomic context

See SIRT7 in Genome Data Viewer
Location:
17q25.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81911939..81918176, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82779099..82785336, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79869815..79876052, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9161 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79850899-79851114 Neighboring gene anaphase promoting complex subunit 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9164 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79875237-79876133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12984 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:79880785-79881984 Neighboring gene MAF bZIP transcription factor G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79882682-79883637 Neighboring gene MAFG antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9171 Neighboring gene MYC inducible lncRNA inactivating p53

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC126840, MGC126842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein-lysine depropionylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K14 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K18 deacetylase activity, NAD-dependent IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3K18 deacetylase activity, NAD-dependent IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K18 deacetylase activity, NAD-dependent IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3K4 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K56 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K9 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K16 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-glutaryllysine deglutarylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-glutaryllysine deglutarylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-succinyllysine desuccinylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-succinyllysine desuccinylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair-dependent chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA repair-dependent chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in R-loop processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of rRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deglutarylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein depropionylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in rRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription initiation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transposable element silencing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus organizer region IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-7
Names
NAD-dependent deacetylase sirtuin-7
NAD-dependent protein deacylase sirtuin-7
SIR2-like protein 7
regulatory protein SIR2 homolog 7
silent mating type information regulation 2, S.cerevisiae, homolog 7
sir2-related protein type 7
sirtuin type 7
NP_057622.1
XP_011521882.1
XP_047292184.1
XP_047292185.1
XP_047292186.1
XP_047292187.1
XP_054172376.1
XP_054172377.1
XP_054172378.1
XP_054172379.1
XP_054172380.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016538.3NP_057622.1  NAD-dependent protein deacetylase sirtuin-7

    See identical proteins and their annotated locations for NP_057622.1

    Status: REVIEWED

    Source sequence(s)
    BC017305, BC101791, BQ890203, CD579273
    Consensus CDS
    CCDS11792.1
    UniProtKB/Swiss-Prot
    A8K2K0, B3KSU8, Q3MIK4, Q9NRC8, Q9NSZ6, Q9NUS6
    Related
    ENSP00000329466.6, ENST00000328666.11
    Conserved Domains (2) summary
    COG1196
    Location:794
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01410
    Location:100314
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81911939..81918176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523580.2XP_011521882.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

    See identical proteins and their annotated locations for XP_011521882.1

    Conserved Domains (1) summary
    cd01410
    Location:78279
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
  2. XM_047436229.1XP_047292185.1  NAD-dependent protein deacetylase sirtuin-7 isoform X3

  3. XM_047436228.1XP_047292184.1  NAD-dependent protein deacetylase sirtuin-7 isoform X2

  4. XM_047436231.1XP_047292187.1  NAD-dependent protein deacetylase sirtuin-7 isoform X5

  5. XM_047436230.1XP_047292186.1  NAD-dependent protein deacetylase sirtuin-7 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82779099..82785336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316401.1XP_054172376.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

  2. XM_054316403.1XP_054172378.1  NAD-dependent protein deacetylase sirtuin-7 isoform X3

  3. XM_054316402.1XP_054172377.1  NAD-dependent protein deacetylase sirtuin-7 isoform X2

  4. XM_054316405.1XP_054172380.1  NAD-dependent protein deacetylase sirtuin-7 isoform X5

  5. XM_054316404.1XP_054172379.1  NAD-dependent protein deacetylase sirtuin-7 isoform X4