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HMBS hydroxymethylbilane synthase [ Bos taurus (domestic cattle) ]

Gene ID: 515614, updated on 29-Jan-2025

Summary

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Official Symbol
HMBSprovided by VGNC
Official Full Name
hydroxymethylbilane synthaseprovided by VGNC
Primary source
VGNC:VGNC:29870
See related
BGD:BT17531; Ensembl:ENSBTAG00000005364
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See HMBS in Genome Data Viewer
Location:
chromosome: 15
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (29666771..29674064)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene hypoxia up-regulated 1 Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene H2A.X variant histone Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC137625

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hydroxymethylbilane synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-pyrromethane cofactor linkage IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
porphobilinogen deaminase
NP_001039672.1
XP_024831019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046207.1 → NP_001039672.1  porphobilinogen deaminase

    See identical proteins and their annotated locations for NP_001039672.1

    Status: PROVISIONAL

    Source sequence(s)
    BC112573
    UniProtKB/Swiss-Prot
    Q2KIN5
    UniProtKB/TrEMBL
    A0AAA9TB78
    Related
    ENSBTAP00070048456.1, ENSBTAT00070080035.1
    Conserved Domains (2) summary
    PRK00072
    Location:18 → 344
    hemC; porphobilinogen deaminase; Reviewed
    cd13645
    Location:20 → 299
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    29666771..29674064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024975251.2 → XP_024831019.1  porphobilinogen deaminase isoform X1

    UniProtKB/TrEMBL
    A0AAA9S1X9
    Related
    ENSBTAP00070048402.1, ENSBTAT00070079931.1
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KIN5.1 GenPept UniProtKB/Swiss-Prot:Q2KIN5

Gene LinkOut

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