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bont botulinum neurotoxin subtype A1 [ Clostridium botulinum A str. ATCC 3502 ]

Gene ID: 5185061, updated on 11-Apr-2024

Summary

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Gene symbol
bont
Gene description
botulinum neurotoxin subtype A1
Locus tag
CBO_RS04150
Gene type
protein coding
RefSeq status
PIPELINE
Organism
Clostridium botulinum A str. ATCC 3502 (strain: ATCC 3502)
Lineage
Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Clostridium
Old locus tag
CBO0806
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Genomic context

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Sequence:
NC_009495.1 (909709..913599)

NC_009495.1Genomic Context describing neighboring genes Neighboring gene botulinum neurotoxin transcription-activating sigma factor BotR Neighboring gene non-toxic nonhemagglutinin NTNH Neighboring gene IS3 family transposase Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009495.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Botulinum toxin type A: an effective treatment to restore phonation in laryngectomized patients unable to voice. Bartolomei L, et al. Neurol Sci, 2011 Jun. PMID 21479612
  2. Comparative membrane channel size and activity of botulinum neurotoxins A and E. Parikh S, et al. Protein J, 2007 Jan. PMID 17216364
  3. A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism? Caleo M, et al. J Neurochem, 2009 Apr. PMID 19154335
  4. Neuritogenic actions of botulinum neurotoxin A on cultured motor neurons. Coffield JA, et al. J Pharmacol Exp Ther, 2009 Jul. PMID 19372387, Free PMC Article
  5. Central origin of the antinociceptive action of botulinum toxin type A. Bach-Rojecky L, et al. Pharmacol Biochem Behav, 2009 Dec. PMID 19732788

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Light Chain Domain and Especially the C-Terminus of Receptor-Binding Domain of the Botulinum Neurotoxin (BoNT) Are the Hotspots for Amino Acid Variability and Toxin Type Diversity.
    Title: The Light Chain Domain and Especially the C-Terminus of Receptor-Binding Domain of the Botulinum Neurotoxin (BoNT) Are the Hotspots for Amino Acid Variability and Toxin Type Diversity.
  2. Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA has been reported.
    Title: Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA.
  3. Inactivation of codY resulted in decreased expression of botA, encoding the neurotoxin.
    Title: Positive regulation of botulinum neurotoxin gene expression by CodY in Clostridium botulinum ATCC 3502.
  4. These data help delineate why alpha-exosite binding is needed for SNAP-25 cleavage and also provide new insights into the extended lifetime observed for BoNT/A LC in vivo.
    Title: Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity.
  5. The importance of structural flexibility in the toxin's mechanism of survival and action is shown, an unmatched evolutionary trait from billion-year-old bacteria, also correlates with the long-lasting enzymatic activity of BoNT inside neuronal cells.
    Title: Botulinum neurotoxin: unique folding of enzyme domain of the most-poisonous poison.
  6. Constructed a deletion mutant of the binding domain of BoNT/A. The rBoNT/A-HCC at dose of 40 mug/mouse generated high IgG antibody titre with predominance of IgG1 subtype, but failed to protect animals against BoNT/A challenge.
    Title: Deletion mutant comprising 198 residues of BoNT/A toxin receptor binding domain retained gt1b binding property but failed to induce protective antibody response in a mouse model.
  7. BTX-A administration significantly reduces mechanical allodynia bilaterally and inhibits P2X3 purinergic receptor over-expression induced by lumbar ventral root transection.
    Title: Botulinum toxin decreases hyperalgesia and inhibits P2X3 receptor over-expression in sensory neurons induced by ventral root transection in rats.
  8. BoNT/A impedes injury-activated neuronal function as displayed by upregulation of neuropeptide mRNA and a downregulation of proenkephalin mRNA in dorsal root ganglia.
    Title: The effect of botulinum neurotoxin A on sciatic nerve injury-induced neuroimmunological changes in rat dorsal root ganglia and spinal cord.
  9. A significant decrease is found in salivary flow rate at 1- and 3-month follow-up in the botulinum toxin A-treated group of children with sialorrhea and cerebral palsy.
    Title: Botulinum toxin type A on oral health in treating sialorrhea in children with cerebral palsy: a randomized, double-blind, placebo-controlled study.
  10. BTX therapy, especially when associated with speech therapy, is efficacious in restoring phonation to laryngectomees who are unable to voice because of spasm of the paryngeal constrictor muscles.
    Title: Botulinum toxin type A: an effective treatment to restore phonation in laryngectomized patients unable to voice.
Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Homology

General protein information

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Preferred Names
botulinum neurotoxin subtype A1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009495.1 Reference assembly

    Range
    909709..913599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_011948511.1 botulinum neurotoxin subtype A1 [Clostridium botulinum]

    See identical proteins and their annotated locations for WP_011948511.1

    Status: PIPELINE

    UniProtKB/Swiss-Prot
    A5HZZ9, A7G1U9, P01561, P0DPI0, P0DPI1, P10845, P18639
    UniProtKB/TrEMBL
    Q7B8V4
    Conserved Domains (4) summary
    pfam07951
    Location:1088 → 1293
    Toxin_R_bind_C; Clostridium neurotoxin, C-terminal receptor binding
    pfam01742
    Location:4 → 409
    Peptidase_M27; Clostridial neurotoxin zinc protease
    pfam07952
    Location:549 → 866
    Toxin_trans; Clostridium neurotoxin, Translocation domain
    pfam07953
    Location:885 → 1079
    Toxin_R_bind_N; Clostridium neurotoxin, N-terminal receptor binding
Nucleotide Protein
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