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PLD2 phospholipase D2 [ Bos taurus (domestic cattle) ]

Gene ID: 522159, updated on 29-Jan-2025

Summary

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Official Symbol
PLD2provided by VGNC
Official Full Name
phospholipase D2provided by VGNC
Primary source
VGNC:VGNC:32996
See related
Ensembl:ENSBTAG00000013392
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PLD2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (26543146..26556149, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene chromosome 19 C17orf107 homolog Neighboring gene cholinergic receptor nicotinic epsilon subunit Neighboring gene misshapen like kinase 1 Neighboring gene chromosome 19 C17orf114 homolog Neighboring gene proteasome 20S subunit beta 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Phospholipase D2 mediates acute aldosterone secretion in response to angiotensin II in adrenal glomerulosa cells. Qin H, et al. Endocrinology, 2010 May. PMID 20219982, Free PMC Article
  2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming.
    Title: Phospholipase D2 mediates acute aldosterone secretion in response to angiotensin II in adrenal glomerulosa cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phospholipase D2
Names
PLD 2
choline phosphatase 2
phosphatidylcholine-hydrolyzing phospholipase D2
NP_001069295.1
XP_059734043.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075827.1 → NP_001069295.1  phospholipase D2

    See identical proteins and their annotated locations for NP_001069295.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123547
    UniProtKB/Swiss-Prot
    Q08DV7, Q0V8L6
    UniProtKB/TrEMBL
    A0A3Q1LVT6
    Related
    ENSBTAP00070019274.1, ENSBTAT00070032869.1
    Conserved Domains (5) summary
    cd09845
    Location:614 → 795
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    PLN02866
    Location:67 → 918
    PLN02866; phospholipase D
    cd01254
    Location:180 → 309
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl02563
    Location:62 → 192
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl15239
    Location:335 → 475
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26543146..26556149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059878060.1 → XP_059734043.1  phospholipase D2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LVT6, A0A3Q1MFR2
    Related
    ENSBTAP00070019264.1, ENSBTAT00070032851.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0V8L6.1 GenPept UniProtKB/Swiss-Prot:Q0V8L6

Gene LinkOut

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Molecular Biology Databases
Research Materials