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Vps37a vacuolar protein sorting 37A [ Mus musculus (house mouse) ]

Gene ID: 52348, updated on 27-Nov-2024

Summary

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Official Symbol
Vps37aprovided by MGI
Official Full Name
vacuolar protein sorting 37Aprovided by MGI
Primary source
MGI:MGI:1261835
See related
Ensembl:ENSMUSG00000031600 AllianceGenome:MGI:1261835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D8Ertd531e; 2210018P21Rik; 4930592A21Rik
Summary
Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of ESCRT I complex. Is expressed in several structures, including branchial arch; facial prominence; heart; limb bud; and neural fold. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 53. Orthologous to human VPS37A (VPS37A subunit of ESCRT-I). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 7.2), testis adult (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Vps37a in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (40964482..41004175)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40511742..40551134)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 7666 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene myotubularin related protein 7 Neighboring gene STARR-seq mESC enhancer starr_21271 Neighboring gene STARR-seq mESC enhancer starr_21272 Neighboring gene STARR-seq mESC enhancer starr_21273 Neighboring gene ADAM metallopeptidase domain 24 Neighboring gene high mobility group box 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Xue W, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22566646, Free PMC Article
  2. ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling. Hermosilla Aguayo V, et al. Dev Biol, 2023 Nov. PMID 37573008
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
  
part_of ESCRT I complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 37A
Names
ESCRT-I complex subunit VPS37A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033560.3 → NP_291038.2  vacuolar protein sorting-associated protein 37A

    See identical proteins and their annotated locations for NP_291038.2

    Status: VALIDATED

    Source sequence(s)
    AC158915, AK016385, AK137479, BY085136, BY549007
    Consensus CDS
    CCDS22254.1
    UniProtKB/Swiss-Prot
    Q0VGD1, Q3TBI5, Q3TC15, Q3TC26, Q8CHS8
    Related
    ENSMUSP00000096415.3, ENSMUST00000098817.4
    Conserved Domains (1) summary
    pfam07200
    Location:235 → 376
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    40964482..41004175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243671.2 → XP_030099531.1  vacuolar protein sorting-associated protein 37A isoform X1

    Conserved Domains (1) summary
    pfam07200
    Location:89 → 234
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RNA

  1. XR_003947316.2 RNA Sequence

  2. XR_003947317.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHS8.1 GenPept UniProtKB/Swiss-Prot:Q8CHS8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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