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Parp8 poly (ADP-ribose) polymerase family, member 8 [ Mus musculus (house mouse) ]

Gene ID: 52552, updated on 27-Nov-2024

Summary

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Official Symbol
Parp8provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 8provided by MGI
Primary source
MGI:MGI:1098713
See related
Ensembl:ENSMUSG00000021725 AllianceGenome:MGI:1098713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTD16; D13Ertd275e; 2810430O08Rik
Summary
Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity; kinase binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PARP8 (poly(ADP-ribose) polymerase family member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 8.9), CNS E14 (RPKM 6.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Parp8 in Genome Data Viewer
Location:
13 D2.3; 13 65.32 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (116987378..117162549, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (116850842..117026019, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35773 Neighboring gene Isl1 promoter region Neighboring gene ISL1 transcription factor, LIM/homeodomain Neighboring gene STARR-seq mESC enhancer starr_35774 Neighboring gene RIKEN cDNA 4930435F18 gene Neighboring gene STARR-seq mESC enhancer starr_35775 Neighboring gene STARR-positive B cell enhancer ABC_E8547 Neighboring gene predicted gene, 29767 Neighboring gene protein TCL1B2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation. Anania C, et al. Nat Genet, 2022 Jul. PMID 35817979, Free PMC Article
  2. Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition. Akagi K, et al. Genome Res, 2008 Jun. PMID 18381897, Free PMC Article
  3. Discovery and validation of genes driving drug-intake and related behavioral traits in mice. Roy TA, et al. Genes Brain Behav, 2024 Jan 2. PMID 38164795, Free PMC Article
  4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein-cysteine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein auto-ADP-ribosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP8
Names
ADP-ribosyltransferase diphtheria toxin-like 16
PARP-8
poly [ADP-ribose] polymerase 8
NP_001074478.3
NP_001413994.1
NP_001413995.1
NP_001413996.1
XP_006517781.1
XP_011242981.1
XP_011242982.1
XP_030103181.1
XP_030103182.1
XP_036013983.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081009.3 → NP_001074478.3  protein mono-ADP-ribosyltransferase PARP8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154224, CT025610
    Consensus CDS
    CCDS36790.2
    UniProtKB/TrEMBL
    F8WIK2
    Related
    ENSMUSP00000022239.7, ENSMUST00000022239.8

  2. NM_001427065.1 → NP_001413994.1  protein mono-ADP-ribosyltransferase PARP8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154224, CT025610
    UniProtKB/Swiss-Prot
    Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3

  3. NM_001427066.1 → NP_001413995.1  protein mono-ADP-ribosyltransferase PARP8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154224, CT025610
    UniProtKB/TrEMBL
    F8WIK2

  4. NM_001427067.1 → NP_001413996.1  protein mono-ADP-ribosyltransferase PARP8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154224, CT025610
    UniProtKB/Swiss-Prot
    Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3
    Related
    ENSMUSP00000152911.2, ENSMUST00000223949.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    116987378..117162549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158090.1 → XP_036013983.1  protein mono-ADP-ribosyltransferase PARP8 isoform X4

    UniProtKB/TrEMBL
    B2X2E0
    Conserved Domains (1) summary
    cd01341
    Location:445 → 569
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  2. XM_030247321.2 → XP_030103181.1  protein mono-ADP-ribosyltransferase PARP8 isoform X5

    UniProtKB/TrEMBL
    B2X2E0
    Conserved Domains (1) summary
    cd01341
    Location:362 → 486
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  3. XM_030247322.2 → XP_030103182.1  protein mono-ADP-ribosyltransferase PARP8 isoform X5

    UniProtKB/TrEMBL
    B2X2E0
    Conserved Domains (1) summary
    cd01341
    Location:362 → 486
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  4. XM_011244679.4 → XP_011242981.1  protein mono-ADP-ribosyltransferase PARP8 isoform X2

    Conserved Domains (1) summary
    cd01341
    Location:771 → 895
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  5. XM_006517718.5 → XP_006517781.1  protein mono-ADP-ribosyltransferase PARP8 isoform X1

    Conserved Domains (1) summary
    cd01341
    Location:771 → 895
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  6. XM_011244680.4 → XP_011242982.1  protein mono-ADP-ribosyltransferase PARP8 isoform X3

    Conserved Domains (1) summary
    cl00283
    Location:559 → 608
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027272.3: Suppressed sequence

    Description
    NM_027272.3: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PARP8 (GeneID:79668).
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UD82.1 GenPept UniProtKB/Swiss-Prot:Q3UD82

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