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Ifi27 interferon, alpha-inducible protein 27 [ Mus musculus (house mouse) ]

Gene ID: 52668, updated on 27-Nov-2024

Summary

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Official Symbol
Ifi27provided by MGI
Official Full Name
interferon, alpha-inducible protein 27provided by MGI
Primary source
MGI:MGI:1277180
See related
Ensembl:ENSMUSG00000064215 AllianceGenome:MGI:1277180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ISG12a; Ifi27l1; D12Ertd647e; 1110013J02Rik; 2900026P10Rik
Summary
Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and lamin binding activity. Acts upstream of or within regulation of protein export from nucleus. Predicted to be located in nuclear inner membrane. Predicted to be active in mitochondrial membrane. Is expressed in adrenal gland; heart valve; and testis. Orthologous to several human genes including IFI27 (interferon alpha inducible protein 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 234.6), mammary gland adult (RPKM 205.0) and 16 other tissues See more
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Genomic context

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See Ifi27 in Genome Data Viewer
Location:
12 E; 12 52.93 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103400448..103406504)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103434189..103440245)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene DEAD box helicase 24 Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene STARR-positive B cell enhancer ABC_E2394 Neighboring gene predicted gene, 53758 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene predicted gene, 53759 Neighboring gene interferon, alpha-inducible protein 27 like 2B Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene protein phosphatase 4, regulatory subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice. Fan K, et al. Biochem Biophys Res Commun, 2022 Jun 4. PMID 35367821
  2. Ifi27 is indispensable for mitochondrial function and browning in adipocytes. Jin W, et al. Biochem Biophys Res Commun, 2018 Jun 18. PMID 29730295
  3. Intervention of Inflammatory Monocyte Activity Limits Dermal Fibrosis. Haub J, et al. J Invest Dermatol, 2019 Oct. PMID 31039360
  4. ISG12 is a critical modulator of innate immune responses in murine models of sepsis. Uhrin P, et al. Immunobiology, 2013 Sep. PMID 23747037, Free PMC Article
  5. IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption. Cui X, et al. Adv Sci (Weinh), 2023 Oct. PMID 37544897, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC149996

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in release of cytochrome c from mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon, alpha-inducible protein 27 like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364173.1 → NP_001351102.1  interferon, alpha-inducible protein 27 like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154347
    Consensus CDS
    CCDS36529.1
    UniProtKB/TrEMBL
    Q70LN3, Q8C6G0
    Conserved Domains (1) summary
    pfam06140
    Location:134 → 210
    Ifi-6-16; Interferon-induced 6-16 family

  2. NM_001364174.1 → NP_001351103.1  interferon, alpha-inducible protein 27 like 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154347
    UniProtKB/TrEMBL
    Q70LN3
    Conserved Domains (1) summary
    pfam06140
    Location:114 → 190
    Ifi-6-16; Interferon-induced 6-16 family

  3. NM_026790.2 → NP_081066.2  interferon, alpha-inducible protein 27 like 1 isoform 1

    See identical proteins and their annotated locations for NP_081066.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK075797, BY130471, BY443016
    Consensus CDS
    CCDS36529.1
    UniProtKB/TrEMBL
    Q70LN3, Q8C6G0
    Related
    ENSMUSP00000082142.6, ENSMUST00000085065.12
    Conserved Domains (1) summary
    pfam06140
    Location:134 → 210
    Ifi-6-16; Interferon-induced 6-16 family

  4. NM_194066.2 → NP_919042.2  interferon, alpha-inducible protein 27 like 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame small exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK075797, BY130471, BY443016
    Consensus CDS
    CCDS36530.1
    UniProtKB/TrEMBL
    E9Q1C5, Q70LN2
    Related
    ENSMUSP00000078275.6, ENSMUST00000079294.12
    Conserved Domains (1) summary
    pfam06140
    Location:125 → 200
    Ifi-6-16; Interferon-induced 6-16 family

  5. NM_194067.2 → NP_919043.1  interferon, alpha-inducible protein 27 like 1 isoform 3

    See identical proteins and their annotated locations for NP_919043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK003665, AK075797, BY130471, BY443016
    Consensus CDS
    CCDS26130.1
    UniProtKB/TrEMBL
    Q3UK07, Q9D1E1
    Related
    ENSMUSP00000068729.7, ENSMUST00000066701.13
    Conserved Domains (1) summary
    pfam06140
    Location:89 → 165
    Ifi-6-16; Interferon-induced 6-16 family

  6. NM_194068.2 → NP_919044.1  interferon, alpha-inducible protein 27 like 1 isoform 4

    See identical proteins and their annotated locations for NP_919044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons in the CDS, as compared to variant 1. The reading frame is not affected and the resulting isoform (4) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK075797, BY130471, BY443016
    Consensus CDS
    CCDS26131.1
    UniProtKB/TrEMBL
    Q70LN0
    Related
    ENSMUSP00000075994.6, ENSMUST00000076702.12
    Conserved Domains (1) summary
    pfam06140
    Location:79 → 155
    Ifi-6-16; Interferon-induced 6-16 family

  7. NM_194069.2 → NP_919045.1  interferon, alpha-inducible protein 27 like 1 isoform 5

    See identical proteins and their annotated locations for NP_919045.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three exons in the CDS, as compared to variant 1. The reading frame is not affected and the resulting isoform (5) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC125636, BY130468, BY443016
    Consensus CDS
    CCDS26132.1
    UniProtKB/TrEMBL
    Q70LM9
    Related
    ENSMUSP00000076068.6, ENSMUST00000076788.12
    Conserved Domains (1) summary
    pfam06140
    Location:40 → 115
    Ifi-6-16; Interferon-induced 6-16 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    103400448..103406504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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