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Cd300lg CD300 molecule like family member G [ Mus musculus (house mouse) ]

Gene ID: 52685, updated on 4-Jan-2025

Summary

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Official Symbol
Cd300lgprovided by MGI
Official Full Name
CD300 molecule like family member Gprovided by MGI
Primary source
MGI:MGI:1289168
See related
Ensembl:ENSMUSG00000017309 AllianceGenome:MGI:1289168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clm9; D11Ertd736e; 2310016B05Rik
Summary
Enables IgM binding activity. Acts upstream of or within immunoglobulin transcytosis in epithelial cells. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human CD300LG (CD300 molecule like family member g). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 49.1), mammary gland adult (RPKM 34.6) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Cd300lg in Genome Data Viewer
Location:
11 D; 11 65.48 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101932337..101946443)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102041511..102055617)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CFAP97 domain containing 1 Neighboring gene membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) Neighboring gene predicted gene, 39393 Neighboring gene membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) Neighboring gene pancreatic polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis. Lee-Ødegård S, et al. Elife, 2024 Aug 27. PMID 39190027, Free PMC Article
  2. Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions. Umemoto E, et al. PLoS One, 2013. PMID 24376728, Free PMC Article
  3. Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro. Jin S, et al. FEBS Lett, 2008 Sep 3. PMID 18675811
  4. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. Umemoto E, et al. J Exp Med, 2006 Jun 12. PMID 16754720, Free PMC Article
  5. CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium. Takatsu H, et al. Biochem Biophys Res Commun, 2006 Sep 15. PMID 16876123

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nepmucin/CD300LG expression in microvascular endothelial cells
    Title: Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions.
  2. These results suggest that endothelial nepmucin promotes lymphocyte transendothelial migration using multiple adhesion pathways.
    Title: Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro.
  3. nepmucin may serve as a dual-functioning in peripheral node addressin in endothial venules mediating both lymphocyte rolling and binding via different functional domains.
    Title: Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgM binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immunoglobulin transcytosis in epithelial cells IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in multivesicular body membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CMRF35-like molecule 9
Names
CD300 antigen like family member G
CLM-9
CMRF-35-like molecule-9
nepmucin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160711.2 → NP_001154183.1  CMRF35-like molecule 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001154183.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL591145
    Consensus CDS
    CCDS48939.1
    UniProtKB/Swiss-Prot
    Q1ERP8
    Related
    ENSMUSP00000102782.3, ENSMUST00000107164.3
    Conserved Domains (2) summary
    cd05716
    Location:24 → 121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 123
    IG_like; Immunoglobulin like

  2. NM_001160712.2 → NP_001154184.1  CMRF35-like molecule 9 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001154184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AL591145
    UniProtKB/Swiss-Prot
    A2A503, Q1ERP8, Q1ERP9, Q1ERQ0, Q3UU12, Q6SJP9, Q9D7B8
    Conserved Domains (2) summary
    cd05716
    Location:24 → 121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 123
    IG_like; Immunoglobulin like

  3. NM_001160713.2 → NP_001154185.1  CMRF35-like molecule 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001154185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AL591145
    Consensus CDS
    CCDS48940.1
    UniProtKB/Swiss-Prot
    Q1ERP8
    Related
    ENSMUSP00000102781.3, ENSMUST00000107163.9
    Conserved Domains (2) summary
    cd05716
    Location:24 → 121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 123
    IG_like; Immunoglobulin like

  4. NM_027987.4 → NP_082263.2  CMRF35-like molecule 9 isoform 4 precursor

    See identical proteins and their annotated locations for NP_082263.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon and a segment in the CDS, as compared to variant 1. The reading frame is not affected and the resulting isoform (4) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AL591145
    Consensus CDS
    CCDS25484.1
    UniProtKB/Swiss-Prot
    Q1ERP8
    Related
    ENSMUSP00000017453.6, ENSMUST00000017453.12
    Conserved Domains (2) summary
    cd05716
    Location:24 → 121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 123
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101932337..101946443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533713.1 → XP_006533776.1  CMRF35-like molecule 9 isoform X1

    Conserved Domains (2) summary
    cd05716
    Location:24 → 121
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    PHA03247
    Location:131 → 285
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1ERP8.1 GenPept UniProtKB/Swiss-Prot:Q1ERP8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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