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Vamp4 vesicle-associated membrane protein 4 [ Mus musculus (house mouse) ]

Gene ID: 53330, updated on 27-Nov-2024

Summary

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Official Symbol
Vamp4provided by MGI
Official Full Name
vesicle-associated membrane protein 4provided by MGI
Primary source
MGI:MGI:1858730
See related
Ensembl:ENSMUSG00000026696 AllianceGenome:MGI:1858730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vamp-4; D1Ertd147e
Summary
Acts upstream of or within Golgi to plasma membrane protein transport; cellular response to type II interferon; and regulation of Golgi to plasma membrane protein transport. Located in phagocytic vesicle and trans-Golgi network. Part of SNARE complex. Is active in presynaptic endosome membrane. Is expressed in cerebellum layer; gonad; and ventral tegmental area. Orthologous to human VAMP4 (vesicle associated membrane protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 8.9), cortex adult (RPKM 8.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Vamp4 in Genome Data Viewer
Location:
1 H2.1; 1 70.29 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162398084..162426651)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162570515..162599082)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46247 Neighboring gene methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E5839 Neighboring gene STARR-positive B cell enhancer ABC_E7767 Neighboring gene STARR-positive B cell enhancer ABC_E10051 Neighboring gene eukaryotic translation initiation factor 4E family member 1B pseudogene Neighboring gene myocilin Neighboring gene myocilin opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes. Ivanova D, et al. Sci Adv, 2021 Apr. PMID 33931449, Free PMC Article
  2. VAMP4 regulates insulin levels by targeting secretory granules to lysosomes. Li M, et al. J Cell Biol, 2022 Oct 3. PMID 36053215, Free PMC Article
  3. Neurite outgrowth induced by NGF or L1CAM via activation of the TrkA receptor is sustained also by the exocytosis of enlargeosomes. Colombo F, et al. Proc Natl Acad Sci U S A, 2014 Nov 25. PMID 25385598, Free PMC Article
  4. Cholesterol accumulation increases insulin granule size and impairs membrane trafficking. Bogan JS, et al. Traffic, 2012 Nov. PMID 22889194, Free PMC Article
  5. VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission. Raingo J, et al. Nat Neurosci, 2012 Mar 11. PMID 22406549, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cholesterol modulates Vamp4 distribution in insulin granule membranes.
    Title: Cholesterol accumulation increases insulin granule size and impairs membrane trafficking.
  2. The cytoplasmic domain of this protein is responsible for its correct subcellular targeting, the N-terminal extension contains a dominant autonomous targeting signal for the trans-golgi network
    Title: The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in Golgi ribbon formation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SNARE complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle to endosome fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
vesicle-associated membrane protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347125.1 → NP_001334054.1  vesicle-associated membrane protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138218
    Consensus CDS
    CCDS83616.1
    UniProtKB/Swiss-Prot
    O70480, Q9D095
    Related
    ENSMUSP00000115133.2, ENSMUST00000150040.8
    Conserved Domains (1) summary
    cd15869
    Location:50 → 116
    R-SNARE_VAMP4; SNARE motif of VAMP4

  2. NM_001356526.1 → NP_001343455.1  vesicle-associated membrane protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC138218
    Consensus CDS
    CCDS15421.1
    UniProtKB/TrEMBL
    Q8BSN6
    Related
    ENSMUSP00000121977.2, ENSMUST00000132158.8
    Conserved Domains (1) summary
    cd15869
    Location:50 → 116
    R-SNARE_VAMP4; SNARE motif of VAMP4

  3. NM_001356527.1 → NP_001343456.1  vesicle-associated membrane protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138218
    Consensus CDS
    CCDS83616.1
    UniProtKB/Swiss-Prot
    O70480, Q9D095
    Related
    ENSMUSP00000116376.2, ENSMUST00000135241.8
    Conserved Domains (1) summary
    cd15869
    Location:50 → 116
    R-SNARE_VAMP4; SNARE motif of VAMP4

  4. NM_016796.3 → NP_058076.2  vesicle-associated membrane protein 4 isoform 1

    See identical proteins and their annotated locations for NP_058076.2

    Status: VALIDATED

    Source sequence(s)
    AK031151
    Consensus CDS
    CCDS15421.1
    UniProtKB/TrEMBL
    Q8BSN6
    Related
    ENSMUSP00000051544.5, ENSMUST00000050010.11
    Conserved Domains (1) summary
    cd15869
    Location:50 → 116
    R-SNARE_VAMP4; SNARE motif of VAMP4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    162398084..162426651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70480.1 GenPept UniProtKB/Swiss-Prot:O70480

Gene LinkOut

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