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ACXE Adenylyl cyclase X E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53426, updated on 4-Jan-2025

Summary

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Official Symbol
ACXEprovided by FlyBase
Official Full Name
Adenylyl cyclase X Eprovided by FlyBase
Primary source
FLYBASE:FBgn0040506
Locus tag
Dmel_CG17178
See related
AllianceGenome:FB:FBgn0040506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AC; CG17178; DACXE; Dmel\CG17178
Summary
Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADCY2 (adenylate cyclase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See ACXE in Genome Data Viewer
Location:
34A2-34A2; 2-47 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12925611..12929823)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12925611..12929823)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Adenylyl cyclase X B Neighboring gene Adenylyl cyclase X A Neighboring gene long non-coding RNA:CR44183 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Jan. PMID 10603085
  2. A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Apr. PMID 11180822
  3. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378
  4. Genome-wide mapping of matrix attachment regions in Drosophila melanogaster. Pathak RU, et al. BMC Genomics, 2014 Nov 25. PMID 25424749, Free PMC Article
  5. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenylyl cyclase X E
Names
ACXE-PB
CG17178-PB
NP_652601.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12925611..12929823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144344.3 → NP_652601.3  adenylyl cyclase X E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652601.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F3YDG3, Q9VK50
    UniProtKB/TrEMBL
    Q9NJ94
    Conserved Domains (2) summary
    pfam16214
    Location:31 → 272
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    cl11967
    Location:290 → 459
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BI83 Q5BI83
Q9NJ94 Q9NJ94
Q9VK50.3 Q9VK50

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