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HGTX HGTX [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53446, updated on 4-Jan-2025

Summary

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Official Symbol
HGTXprovided by FlyBase
Official Full Name
HGTXprovided by FlyBase
Primary source
FLYBASE:FBgn0040318
Locus tag
Dmel_CG13475
See related
AllianceGenome:FB:FBgn0040318
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13475; CG4745; Dmel\CG13475; dNkx6; Nk6; nkx6; Nkx6
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and DNA-binding transcription factor binding activity. Involved in negative regulation of gene expression; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; gut section; head epidermis primordium; neurosecretory neurons; and segmentally-repeated neuroblast. Used to study obesity. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See HGTX in Genome Data Viewer
Location:
70E3-70E3; 3-42 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14583222..14599540, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14576322..14592640, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44843 Neighboring gene uncharacterized protein Neighboring gene Leucokinin Neighboring gene uncharacterized protein Neighboring gene shade Neighboring gene uncharacterized protein Neighboring gene RecQ5 helicase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila Nkx6 homeodomain protein has both activation and repression domains and can activate target gene expression. Syu LJ, et al. Brain Res, 2009 Apr 17. PMID 19232326
  2. A novel temporal identity window generates alternating Eve(+)/Nkx6(+) motor neuron subtypes in a single progenitor lineage. Seroka A, et al. Neural Dev, 2020 Jul 28. PMID 32723364, Free PMC Article
  3. Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. Valsesia A, et al. Nat Commun, 2019 Feb 1. PMID 30710084, Free PMC Article
  4. The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors. Santiago C, et al. Cell Rep, 2014 Apr 10. PMID 24685136, Free PMC Article
  5. Crossing the border: molecular control of motor axon exit. Bravo-Ambrosio A, et al. Int J Mol Sci, 2011. PMID 22272090, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel temporal identity window generates alternating Eve(+)/Nkx6(+) motor neuron subtypes in a single progenitor lineage.
    Title: A novel temporal identity window generates alternating Eve(+)/Nkx6(+) motor neuron subtypes in a single progenitor lineage.
  2. These results indicate that the anteroposterior patterning gene ems controls the expression of DV genes, and vice versa.
    Title: Ems and Nkx6 are central regulators in dorsoventral patterning of the Drosophila brain.
  3. Nkx6 protein has both activation & repression domains; over-expression of Nkx6 results in an increase in the number of Fascilin II expressing motor neurons in the intersegmental nerve B branch
    Title: The Drosophila Nkx6 homeodomain protein has both activation and repression domains and can activate target gene expression.
  4. Nkx6 acts in a specific neuronal population to link neuronal subtype identity to neuronal morphology and connectivity
    Title: Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis.
  5. In vnd mutants, head neuroectoderm Nk6 expression is abolished where it is normally co-expressed with vnd.
    Title: Nk6, a novel Drosophila homeobox gene regulated by vnd.
  6. Overexpression of fish or fly Nkx6 is sufficient to generate supernumerary motoneurons in both zebrafish and flies
    Title: Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
HGTX
Names
CG13475-PA
CG13475-PC
HGTX-PA
HGTX-PC
Nk6 homeobox
NP_001368954.1
  • non-AUG (AAG) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14583222..14599540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382022.1 → NP_001368954.1  HGTX, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6J3T5M5, Q8SXK1
    Conserved Domains (2) summary
    COG5422
    Location:179 → 388
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    pfam00046
    Location:469 → 523
    Homeobox; Homeobox domain

  2. NM_144357.3 → NP_652614.1  HGTX, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652614.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXK1, Q9NHP8, Q9VUF6
    Related
    FBpp0075463
    Conserved Domains (1) summary
    pfam00046
    Location:395 → 448
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6J3T5M5 A0A6J3T5M5
Q8SXK1 Q8SXK1
Q9NHP8 Q9NHP8

Gene LinkOut

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