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SP1029 SP1029 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53473, updated on 4-Jan-2025

Summary

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Official Symbol
SP1029provided by FlyBase
Official Full Name
SP1029provided by FlyBase
Primary source
FLYBASE:FBgn0263236
Locus tag
Dmel_CG11956
See related
AllianceGenome:FB:FBgn0263236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11956; Dmel\CG11956; ptl; ptls; Sp1029
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including adult head; embryonic head epidermis; embryonic maxillary sensory complex; embryonic ventral epidermis; and epithelium. Orthologous to human ANPEP (alanyl aminopeptidase, membrane). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See SP1029 in Genome Data Viewer
Location:
99A4-99A5; 3-98 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29244961..29250451, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25070683..25076173, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene string Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cis-regulatory elements of the mitotic regulator, string/Cdc25. Lehman DA, et al. Development, 1999 May. PMID 10101114, Free PMC Article
  2. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
  3. Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. Edgar BA, et al. Development, 1994 Nov. PMID 7720557, Free PMC Article
  4. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540
  5. Specific transcriptional responses to juvenile hormone and ecdysone in Drosophila. Beckstead RB, et al. Insect Biochem Mol Biol, 2007 Jun. PMID 17517334, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SP1029
Names
CG11956-PA
CG11956-PB
CG11956-PC
CG11956-PD
CG11956-PE
SP1029-PA
SP1029-PB
SP1029-PC
SP1029-PD
SP1029-PE
pathless

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29244961..29250451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144361.2 → NP_652618.1  SP1029, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652618.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI00, Q6IDH1, Q9NH67
    Related
    FBpp0084767
    Conserved Domains (3) summary
    cd09601
    Location:43 → 502
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:33 → 431
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:583 → 908
    ERAP1_C; ERAP1-like C-terminal domain

  2. NM_170405.2 → NP_733284.1  SP1029, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI00, Q6IDH1, Q9NH67
    Related
    FBpp0084768
    Conserved Domains (3) summary
    cd09601
    Location:43 → 502
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:33 → 431
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:583 → 908
    ERAP1_C; ERAP1-like C-terminal domain

  3. NM_001276136.1 → NP_001263065.1  SP1029, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263065.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI00, Q6IDH1, Q9NH67
    Conserved Domains (3) summary
    cd09601
    Location:43 → 502
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:33 → 431
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:583 → 908
    ERAP1_C; ERAP1-like C-terminal domain

  4. NM_001300651.1 → NP_001287580.1  SP1029, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287580.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI00, Q6IDH1, Q9NH67
    Conserved Domains (3) summary
    cd09601
    Location:43 → 502
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:33 → 431
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:583 → 908
    ERAP1_C; ERAP1-like C-terminal domain

  5. NM_170406.2 → NP_733285.1  SP1029, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733285.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI00, Q6IDH1, Q9NH67
    Related
    FBpp0084769
    Conserved Domains (3) summary
    cd09601
    Location:43 → 502
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:33 → 431
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:583 → 908
    ERAP1_C; ERAP1-like C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KI00 Q0KI00
Q960U1 Q960U1
Q9NH67 Q9NH67

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