Timm23 translocase of inner mitochondrial membrane 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Timm23provided by MGI
Official Full Name: translocase of inner mitochondrial membrane 23provided by MGI
Primary source: MGI:MGI:1858317
See related: Ensembl:ENSMUSG00000013701 AllianceGenome:MGI:1858317
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tim23
Summary: Predicted to enable enzyme binding activity and protein transmembrane transporter activity. Predicted to be involved in positive regulation of protein processing; protein transport; and type 2 mitophagy. Located in migrasome and mitochondrion. Is expressed in several structures, including central nervous system; heart; orbito-sphenoid; submandibular gland primordium; and tooth. Orthologous to several human genes including TIMM23 (translocase of inner mitochondrial membrane 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 102.6), placenta adult (RPKM 64.7) and 28 other tissues See more
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Genomic context

Location:: 14 B; 14 19.4 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (31902123..31923848, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (32180166..32201891, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.
Title: NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.
Mutant huntingtin does not cross the mitochondrial outer membrane.
Title: Mutant huntingtin does not cross the mitochondrial outer membrane.
Combined Poly(ADP-ribose) glycohydrolase and Parp-1 loss with a hypomorphic state of Timm23 leads to the development of severe renal failure.
Title: Development of renal failure in PargParp-1 null and Timm23 hypomorphic mice.
While TOM20 overexpression exacerbated neurodegeneration in Parkinson's disease model, in both substantia nigra pars compacta and striatum, overexpression of TIM23 partially protected dopaminergic neurons in the substantia nigra pars compacta.
Title: Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease.
Targeted to translocase of the inner membrane channel subunit 23 (Tim23).
Title: Effect of Tim23 knockdown in vivo on mitochondrial protein import and retrograde signaling to the UPR(mt) in muscle.
Heterozygote Tim23 knockout mice exhibit a reduced lifespan and defective mitochondrial import.
Title: Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Mit254 (e-PCR), detects polymorphism
- UniSTS:127365

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info
involved_in type 2 mitophagy	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	IEA Inferred from Electronic Annotation more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISO Inferred from Sequence Orthology more info
located_in migrasome	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit Tim23

Names: translocase of inner mitochondrial membrane 23 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.