PTOV1 PTOV1 extended AT-hook containing adaptor protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTOV1provided by HGNC
Official Full Name: PTOV1 extended AT-hook containing adaptor proteinprovided by HGNC
Primary source: HGNC:HGNC:9632
See related: Ensembl:ENSG00000104960 MIM:610195; AllianceGenome:HGNC:9632
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACID2; PTOV-1
Summary: This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression: Ubiquitous expression in testis (RPKM 29.1), adrenal (RPKM 28.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.33

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (49850705..49860742)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (52850843..52860879)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (50353962..50363999)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the acquisition of resistance in laryngeal cancer seems to be related to PTOV1
Title: Autophagy inhibition as a promising therapeutic target for laryngeal cancer.
PTOV1 interaction with translation complexes and its direct binding to ALDH1A1 and CCNG2 promoters found here reveal the PTOV1 capacity to modulate the expression of critical genes at multiple levels in aggressive cancers.
Title: A novel DNA-binding motif in prostate tumor overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells.
PTOV1 and PIN1 interact and exert oncogenic role in MDA-MB-231 cells by sharing the similar expression profile at transcriptional and translational level which can be a promising hub for therapeutic target.
Title: Knockdown of PTOV1 and PIN1 exhibit common phenotypic anti-cancer effects in MDA-MB-231 cells.
this study revealed PTOV1 as a poor prognosis factor for NSCLC patients, and targeting PTOV1 can be a strategy to increase chemosensitivity in NSCLC.
Title: Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits.
The combination of PTOV1 expression level and HPV status provides more prognostic information compared with HPV status alone in early-stage human laryngeal squamous cell carcinoma.
Title: Prostate tumor overexpressed-1, in conjunction with human papillomavirus status, predicts outcome in early-stage human laryngeal squamous cell carcinoma.
Studies indicate that the number of binding partners and associated cellular functions has increased and helped to identify prostate-tumor-overexpressed-1 (PTOV1) as regulator of gene expression at transcription and translation levels.
Title: The role of prostate tumor overexpressed 1 in cancer progression.
this study takes the lead to demonstrate that the overexpressed PTOV1 plays a vital role in the tumorigenesis and progression of esophageal squamous cell carcinoma, and it is potentially a valuable prognostic predicator and new chemotherapeutic target for esophageal squamous cell carcinoma
Title: Overexpressed PTOV1 associates with tumorigenesis and progression of esophageal squamous cell carcinoma.
All the study samples showed a considerable decrease in PTOV1 expression in prostate cancer and HGPIN compared to morphologically normal glands.
Title: [Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms].
High PTOV1 expression was associated with invasive urothelial carcinoma.
Title: Prostate tumor overexpressed 1 expression in invasive urothelial carcinoma.
PTOV1 overexpression is associated with poor survival outcomes of nasopharyngeal carcinoma patients.
Title: Prostate Tumor Overexpressed 1 (PTOV1) Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Poor Survival Outcomes.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-15464 (e-PCR)
- UniSTS:15129

STS-AA018544 (e-PCR)
- UniSTS:26322

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostate tumor-overexpressed gene 1 protein

Names: activator interaction domain-containing protein 2; prostate tumor overexpressed 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050666.1 RefSeqGene

Range

6892..16901

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001305105.2 → NP_001292034.1 prostate tumor-overexpressed gene 1 protein isoform 1

See identical proteins and their annotated locations for NP_001292034.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1). This transcript contains splicing in the 3' UTR that makes it a candidate for nonsense-mediated mRNA decay (NMD). However, this protein is thought to be valid.

Source sequence(s)

AA582677, AC018766, AJ617480

Consensus CDS

CCDS12782.1

UniProtKB/Swiss-Prot

Q6UXX7, Q86YD1, Q96BU3, Q9HBN4, Q9NYL1

Related

ENSP00000469128.1, ENST00000599732.5

Conserved Domains (1) summary

pfam11232
Location:93 → 238

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
NM_001305108.2 → NP_001292037.1 prostate tumor-overexpressed gene 1 protein isoform 2

See identical proteins and their annotated locations for NP_001292037.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate exon in the 5' region, initiates translation at an alternate start codon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1.

Source sequence(s)

AC018766

Consensus CDS

CCDS82379.1

UniProtKB/TrEMBL

A0A0C4DGR2

Related

ENSP00000471458.1, ENST00000600603.5

Conserved Domains (1) summary

pfam11232
Location:61 → 206

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
NM_001364745.2 → NP_001351674.1 prostate tumor-overexpressed gene 1 protein isoform 3

Status: REVIEWED

Source sequence(s)

AC018766

Consensus CDS

CCDS92668.1

UniProtKB/TrEMBL

M0QY25

Related

ENSP00000469541.1, ENST00000601638.5

Conserved Domains (1) summary

pfam11232
Location:61 → 206

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
NM_001364747.2 → NP_001351676.1 prostate tumor-overexpressed gene 1 protein isoform 4

Status: REVIEWED

Source sequence(s)

AC018766

Conserved Domains (2) summary

pfam11232
Location:108 → 253

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

cl26247
Location:1 → 156

DNA_pol3_delta2; DNA polymerase III, delta subunit
NM_001364748.2 → NP_001351677.1 prostate tumor-overexpressed gene 1 protein isoform 5

Status: REVIEWED

Source sequence(s)

AC018766

Conserved Domains (1) summary

pfam11232
Location:117 → 258

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
NM_001364749.2 → NP_001351678.1 prostate tumor-overexpressed gene 1 protein isoform 4

Status: REVIEWED

Source sequence(s)

AC018766

Conserved Domains (2) summary

pfam11232
Location:108 → 253

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

cl26247
Location:1 → 156

DNA_pol3_delta2; DNA polymerase III, delta subunit
NM_001364750.2 → NP_001351679.1 prostate tumor-overexpressed gene 1 protein isoform 5

Status: REVIEWED

Source sequence(s)

AC018766

Related

ENST00000598325.5

Conserved Domains (1) summary

pfam11232
Location:117 → 258

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
NM_001394010.1 → NP_001380939.1 prostate tumor-overexpressed gene 1 protein isoform 1

Status: REVIEWED

Source sequence(s)

AC018766

Consensus CDS

CCDS12782.1

UniProtKB/Swiss-Prot

Q6UXX7, Q86YD1, Q96BU3, Q9HBN4, Q9NYL1

Related

ENSP00000375717.1, ENST00000391842.6

Conserved Domains (1) summary

pfam11232
Location:93 → 238

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
NM_017432.5 → NP_059128.2 prostate tumor-overexpressed gene 1 protein isoform 1

See identical proteins and their annotated locations for NP_059128.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This transcript contains splicing in the 3' UTR that makes it a candidate for nonsense-mediated mRNA decay (NMD). However, this protein is thought to be valid.

Source sequence(s)

AA582677, AC018766, BC042921

Consensus CDS

CCDS12782.1

UniProtKB/Swiss-Prot

Q6UXX7, Q86YD1, Q96BU3, Q9HBN4, Q9NYL1

Related

ENSP00000472816.1, ENST00000601675.5

Conserved Domains (1) summary

pfam11232
Location:93 → 238

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

RNA

NR_130963.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses alternate splice sites in two exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC018766

Related

ENST00000601612.5