Caprin1 cell cycle associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Caprin1provided by MGI
Official Full Name: cell cycle associated protein 1provided by MGI
Primary source: MGI:MGI:1858234
See related: Ensembl:ENSMUSG00000027184 AllianceGenome:MGI:1858234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P137; Gpiap; Gpiap1; rng105; Caprin-1; Mmgpip137
Summary: Predicted to enable several functions, including ATP binding activity; molecular condensate scaffold activity; and signaling adaptor activity. Involved in positive regulation of dendritic spine morphogenesis. Acts upstream of or within generation of neurons; intracellular mRNA localization; and synapse assembly. Located in cytoplasmic stress granule. Is active in dendrite and synapse. Is expressed in central nervous system; eye; and genitourinary system. Orthologous to human CAPRIN1 (cell cycle associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 53.6), whole brain E14.5 (RPKM 41.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.43 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (103593292..103627946, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (103762945..103797669, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2.
Title: RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2.
Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice.
Title: Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice.
Thus, RNG105 has an essential role, as a key regulator of dendritic mRNA localization, in long-term memory formation.
Title: RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation.
Behavioral analysis of RNG105 heterozygous mice showed reduced social interaction and attenuated response to novelty.
Title: Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty.
Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes
Title: Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].
Stress-granule-associated protein Caprin-1 is downregulated by Pou4f3.
Title: Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage.
The present study first demonstrates the in vivo role of RNG105 in the dendritic localization of mRNAs
Title: RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks.
Overexpression of a fusion protein of enhanced green fluorescent protein and caprin-1 induces dose-dependent suppression of the proliferation of NIH-3T3 cells, consistent with the notion that caprin-1 plays a role in cellular activation or proliferation.
Title: Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142945 (e-PCR)
- UniSTS:232192

BB255552 (e-PCR)
- UniSTS:207369

RH125390 (e-PCR)
- UniSTS:162212

AA955378 (e-PCR)
- UniSTS:261065

NoName (e-PCR)
- UniSTS:234476

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular function activator activity	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membraneless organelle assembly	IEA Inferred from Electronic Annotation more info
involved_in membraneless organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress granule assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	ISO Inferred from Sequence Orthology more info
involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membraneless organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: caprin-1

Names: GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; RNA granule protein 105; cytoplasmic activation- and proliferation-associated protein 1; cytoplasmic activation/proliferation-associated protein 1; membrane component chromosome 11 surface marker 1; p137GPI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111289.2 → NP_001104759.1 caprin-1 isoform a

See identical proteins and their annotated locations for NP_001104759.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

BX537331

Consensus CDS

CCDS16481.1

UniProtKB/Swiss-Prot

Q60758, Q60865, Q61620, Q6IMN3, Q7TT26

Related

ENSMUSP00000106777.2, ENSMUST00000111147.8

Conserved Domains (1) summary

pfam12287
Location:365 → 677

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
NM_001111290.2 → NP_001104760.1 caprin-1 isoform b

See identical proteins and their annotated locations for NP_001104760.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.

Source sequence(s)

BX537331

UniProtKB/Swiss-Prot

Q60865

Conserved Domains (2) summary

pfam12287
Location:357 → 670

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam18293
Location:130 → 245

Caprin-1_dimer; Caprin-1 dimerization domain
NM_001111291.2 → NP_001104761.1 caprin-1 isoform c

See identical proteins and their annotated locations for NP_001104761.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.

Source sequence(s)

BX537331

UniProtKB/Swiss-Prot

Q60865

Conserved Domains (2) summary

pfam12287
Location:357 → 683

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam18293
Location:130 → 245

Caprin-1_dimer; Caprin-1 dimerization domain
NM_001111292.2 → NP_001104762.1 caprin-1 isoform c

See identical proteins and their annotated locations for NP_001104762.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.

Source sequence(s)

BX537331

UniProtKB/Swiss-Prot

Q60865

Conserved Domains (2) summary

pfam12287
Location:357 → 683

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam18293
Location:130 → 245

Caprin-1_dimer; Caprin-1 dimerization domain
NM_001412568.1 → NP_001399497.1 caprin-1 isoform d

Status: VALIDATED

Source sequence(s)

BX537331
NM_001412569.1 → NP_001399498.1 caprin-1 isoform d

Status: VALIDATED

Source sequence(s)

BX537331
NM_001412570.1 → NP_001399499.1 caprin-1 isoform e

Status: VALIDATED

Source sequence(s)

BX537331
NM_001412571.1 → NP_001399500.1 caprin-1 isoform e

Status: VALIDATED

Source sequence(s)

BX537331
NM_001412572.1 → NP_001399501.1 caprin-1 isoform b

Status: VALIDATED

Source sequence(s)

BX537331
NM_001412574.1 → NP_001399503.1 caprin-1 isoform f

Status: VALIDATED

Source sequence(s)

BX537331
NM_001412575.1 → NP_001399504.1 caprin-1 isoform g

Status: VALIDATED

Source sequence(s)

BX537331
NM_001412576.1 → NP_001399505.1 caprin-1 isoform h

Status: VALIDATED

Source sequence(s)

BX537331
NM_001412577.1 → NP_001399506.1 caprin-1 isoform i

Status: VALIDATED

Source sequence(s)

BX537331
NM_001412578.1 → NP_001399507.1 caprin-1 isoform i

Status: VALIDATED

Source sequence(s)

BX537331
NM_016739.4 → NP_058019.2 caprin-1 isoform a

See identical proteins and their annotated locations for NP_058019.2

Status: VALIDATED

Source sequence(s)

BX537331

Consensus CDS

CCDS16481.1

UniProtKB/Swiss-Prot

Q60758, Q60865, Q61620, Q6IMN3, Q7TT26

Related

ENSMUSP00000028607.7, ENSMUST00000028607.13

Conserved Domains (1) summary

pfam12287
Location:365 → 677

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term