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eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta [ Danio rerio (zebrafish) ]

Gene ID: 541548, updated on 4-Jan-2025

Summary

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Official Symbol
eif2b4provided by ZNC
Official Full Name
eukaryotic translation initiation factor 2B, subunit 4 deltaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-955
See related
Ensembl:ENSDARG00000014004 AllianceGenome:ZFIN:ZDB-GENE-030131-955
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb54a09; zgc:110790; si:ch211-101l18.4
Summary
Predicted to enable translation initiation factor activity. Predicted to act upstream of or within translational initiation. Predicted to be located in cytosol. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See eif2b4 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (19516651..19532536, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (19617071..19633023, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 17 Neighboring gene all-trans retinoic acid-induced differentiation factor Neighboring gene uncharacterized LOC137488637 Neighboring gene transfer RNA leucine (anticodon CAG) Neighboring gene microRNA 133b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response. Keefe MD, et al. Elife, 2020 Dec 10. PMID 33300869, Free PMC Article
  2. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
translation initiation factor eIF2B subunit delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014361.2 → NP_001014383.1  translation initiation factor eIF2B subunit delta

    See identical proteins and their annotated locations for NP_001014383.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091878
    UniProtKB/TrEMBL
    Q58EJ2, Q5RIE1
    Related
    ENSDARP00000106707.2, ENSDART00000125830.4
    Conserved Domains (3) summary
    PHA01732
    Location:74 → 137
    PHA01732; proline-rich protein
    COG1184
    Location:220 → 534
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:236 → 526
    IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    19516651..19532536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160461.5 → XP_005160518.1  translation initiation factor eIF2B subunit delta isoform X2

    UniProtKB/TrEMBL
    A0A286Y8J6, A0A8M2B7A7
    Related
    ENSDARP00000143268.1, ENSDART00000179566.2
    Conserved Domains (3) summary
    PHA01732
    Location:74 → 137
    PHA01732; proline-rich protein
    COG1184
    Location:234 → 548
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:250 → 540
    IF-2B; Initiation factor 2 subunit family

  2. XM_005160462.5 → XP_005160519.1  translation initiation factor eIF2B subunit delta isoform X3

    UniProtKB/TrEMBL
    A0A8M2B7A3
    Conserved Domains (2) summary
    COG1184
    Location:221 → 535
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:237 → 527
    IF-2B; Initiation factor 2 subunit family

  3. XM_005160460.5 → XP_005160517.1  translation initiation factor eIF2B subunit delta isoform X1

    UniProtKB/TrEMBL
    A0A8M2B7A1
    Conserved Domains (2) summary
    COG1184
    Location:235 → 549
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:251 → 541
    IF-2B; Initiation factor 2 subunit family
Nucleotide Protein Strain
Heading Accession and Version

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