U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kyat3 kynurenine aminotransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 541589, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Kyat3provided by RGD
Official Full Name
kynurenine aminotransferase 3provided by RGD
Primary source
RGD:1359262
See related
EnsemblRapid:ENSRNOG00000043426 AllianceGenome:RGD:1359262
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kat3; Ccbl2
Summary
Predicted to enable kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; and protein homodimerization activity. Predicted to be involved in 2-oxoglutarate metabolic process and kynurenine metabolic process. Predicted to be active in mitochondrion. Orthologous to human KYAT3 (kynurenine aminotransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 779.5), Kidney (RPKM 151.7) and 6 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kyat3 in Genome Data Viewer
Location:
2q44
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (234362306..234407646)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (231701881..231747462)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (248644473..248690289)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 1, pseudogene 1 Neighboring gene guanylate binding protein 6, pseudogene 2 Neighboring gene uncharacterized LOC108350125 Neighboring gene RNA, U6 small nuclear 503 Neighboring gene general transcription factor IIB

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Biochemical and structural properties of mouse kynurenine aminotransferase III. Han Q, et al. Mol Cell Biol, 2009 Feb. PMID 19029248, Free PMC Article
  2. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Han Q, et al. Cell Mol Life Sci, 2010 Feb. PMID 19826765, Free PMC Article
  3. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. Yu P, et al. Gene, 2006 Jan 3. PMID 16376499
  4. The kynurenine pathway and neurodegenerative disease. Maddison DC, et al. Semin Cell Dev Biol, 2015 Apr. PMID 25773161
  5. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-S-conjugate beta-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine-glyoxylate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine-glyoxylate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables kynurenine-glyoxylate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kynurenine-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kynurenine-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine-oxoglutarate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables kynurenine-oxoglutarate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-kynurenine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in kynurenine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in kynurenine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
kynurenine--oxoglutarate transaminase 3
Names
KATIII
cysteine conjugate-beta lyase 2
cysteine-S-conjugate beta-lyase 2
kynurenine aminotransferase III
kynurenine aminotransferase III-like
kynurenine--glyoxylate transaminase
kynurenine--oxoglutarate transaminase III
NP_001015037.1
XP_038958899.1
XP_038958900.1
XP_038958902.1
XP_038958903.1
XP_038958904.1
XP_038958905.1
XP_063138487.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015037.1 → NP_001015037.1  kynurenine--oxoglutarate transaminase 3

    See identical proteins and their annotated locations for NP_001015037.1

    Status: PROVISIONAL

    Source sequence(s)
    AY955395
    UniProtKB/Swiss-Prot
    Q58FK9
    Related
    ENSRNOP00000103048.1, ENSRNOT00000153006.1
    Conserved Domains (2) summary
    cd00609
    Location:66 → 447
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK07777
    Location:44 → 452
    PRK07777; aminotransferase; Validated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    234362306..234407646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102972.2 → XP_038958900.1  kynurenine--oxoglutarate transaminase 3 isoform X2

    Conserved Domains (1) summary
    PRK07777
    Location:10 → 418
    PRK07777; putative succinyldiaminopimelate transaminase DapC

  2. XM_039102977.2 → XP_038958905.1  kynurenine--oxoglutarate transaminase 3 isoform X4

    Conserved Domains (1) summary
    PRK08912
    Location:3 → 298
    PRK08912; aminotransferase

  3. XM_039102971.2 → XP_038958899.1  kynurenine--oxoglutarate transaminase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUT0, A6HW71
    Conserved Domains (1) summary
    PRK07777
    Location:44 → 452
    PRK07777; putative succinyldiaminopimelate transaminase DapC

  4. XM_063282417.1 → XP_063138487.1  kynurenine--oxoglutarate transaminase 3 isoform X2

  5. XM_039102974.2 → XP_038958902.1  kynurenine--oxoglutarate transaminase 3 isoform X2

    Related
    ENSRNOP00000108974.1, ENSRNOT00000149481.1
    Conserved Domains (1) summary
    PRK07777
    Location:10 → 418
    PRK07777; putative succinyldiaminopimelate transaminase DapC

  6. XM_039102975.2 → XP_038958903.1  kynurenine--oxoglutarate transaminase 3 isoform X2

    Conserved Domains (1) summary
    PRK07777
    Location:10 → 418
    PRK07777; putative succinyldiaminopimelate transaminase DapC

  7. XM_039102976.2 → XP_038958904.1  kynurenine--oxoglutarate transaminase 3 isoform X3

    Related
    ENSRNOP00000083094.2, ENSRNOT00000101068.2
    Conserved Domains (1) summary
    PRK08912
    Location:17 → 410
    PRK08912; aminotransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58FK9.1 GenPept UniProtKB/Swiss-Prot:Q58FK9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials