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Akap8l A kinase anchor protein 8-like [ Mus musculus (house mouse) ]

Gene ID: 54194, updated on 27-Nov-2024

Summary

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Official Symbol
Akap8lprovided by MGI
Official Full Name
A kinase anchor protein 8-likeprovided by MGI
Primary source
MGI:MGI:1860606
See related
Ensembl:ENSMUSG00000002625 AllianceGenome:MGI:1860606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HAP95; Nakap95
Summary
Predicted to enable histone deacetylase binding activity; lamin binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including cell cycle G2/M phase transition; mitotic chromosome condensation; and regulation of mRNA export from nucleus. Located in nuclear matrix. Is expressed in several structures, including central nervous system and retina. Orthologous to human AKAP8L (A-kinase anchoring protein 8 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cortex adult (RPKM 62.0), frontal lobe adult (RPKM 58.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Akap8l in Genome Data Viewer
Location:
17 B1; 17 17.5 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32540398..32569589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32321424..32350616, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene bromodomain containing 4 Neighboring gene predicted gene 4432 Neighboring gene STARR-positive B cell enhancer ABC_E11795 Neighboring gene STARR-positive B cell enhancer ABC_E5590 Neighboring gene STARR-positive B cell enhancer ABC_E955 Neighboring gene A kinase anchor protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E1502 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32506256-32506557 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32508595-32508896 Neighboring gene widely-interspaced zinc finger motifs Neighboring gene STARR-positive B cell enhancer ABC_E4205 Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32540440-32540643 Neighboring gene predicted gene, 53995 Neighboring gene RAS protein activator like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering. Zhang WY, et al. J Neuroinflammation, 2024 Jul 20. PMID 39033121, Free PMC Article
  2. Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse. Yang Y, et al. J Biol Chem, 2006 Aug 4. PMID 16751186
  3. Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis. Sayer JA, et al. Neuromolecular Med, 2005. PMID 16391387
  4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  5. Comprehensive Proteomic Analysis of PGC7-Interacting Proteins. Liu H, et al. J Proteome Res, 2017 Sep 1. PMID 28712289

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering.
    Title: Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear membrane disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 8-like
Names
A kinase (PRKA) anchor protein 8-like
AKAP8-like protein
neighbor of A-kinase anchoring protein 95
neighbor of AKAP95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403535.1 → NP_001390464.1  A-kinase anchor protein 8-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT033751
    UniProtKB/TrEMBL
    A0A494B9L0
    Related
    ENSMUSP00000157684.2, ENSMUST00000236503.2

  2. NM_001403536.1 → NP_001390465.1  A-kinase anchor protein 8-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT033751

  3. NM_017476.3 → NP_059504.2  A-kinase anchor protein 8-like isoform 1

    See identical proteins and their annotated locations for NP_059504.2

    Status: VALIDATED

    Source sequence(s)
    CT033751
    Consensus CDS
    CCDS50058.1
    UniProtKB/TrEMBL
    Q5RL57, Q9D0K8
    Related
    ENSMUSP00000051389.8, ENSMUST00000050214.9
    Conserved Domains (1) summary
    pfam04988
    Location:389 → 553
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

RNA

  1. NR_175380.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT033751

  2. NR_175381.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT033751

  3. NR_175382.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT033751

  4. NR_175383.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT033751

  5. NR_175384.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT033751

  6. NR_175385.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT033751

  7. NR_175386.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT033751

  8. NR_175387.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT033751

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32540398..32569589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249905.2 → XP_030105765.1  A-kinase anchor protein 8-like isoform X3

    Conserved Domains (1) summary
    pfam04988
    Location:389 → 512
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

RNA

  1. XR_003952164.2 RNA Sequence

  2. XR_003952155.2 RNA Sequence

  3. XR_004939555.1 RNA Sequence

  4. XR_004939560.1 RNA Sequence

  5. XR_003952163.2 RNA Sequence

  6. XR_003952165.2 RNA Sequence

  7. XR_004939559.1 RNA Sequence

  8. XR_003952151.2 RNA Sequence

  9. XR_003952159.1 RNA Sequence

  10. XR_003952154.2 RNA Sequence

  11. XR_004939558.1 RNA Sequence

  12. XR_004939557.1 RNA Sequence

    Related
    ENSMUST00000236105.2

  13. XR_003952162.2 RNA Sequence

  14. XR_003952161.2 RNA Sequence

  15. XR_004939556.1 RNA Sequence

    Related
    ENSMUST00000236039.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0L7.1 GenPept UniProtKB/Swiss-Prot:Q9R0L7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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