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Cdkn2c cyclin-dependent kinase inhibitor 2C [ Rattus norvegicus (Norway rat) ]

Gene ID: 54238, updated on 27-Nov-2024

Summary

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Official Symbol
Cdkn2cprovided by RGD
Official Full Name
cyclin-dependent kinase inhibitor 2Cprovided by RGD
Primary source
RGD:2325
See related
EnsemblRapid:ENSRNOG00000008956 AllianceGenome:RGD:2325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p18
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in oligodendrocyte differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDKN2C (cyclin dependent kinase inhibitor 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 174.6), Spleen (RPKM 105.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdkn2c in Genome Data Viewer
Location:
5q35
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (129639736..129645564, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (124411123..124416278, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (129347731..129352886, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene enolase 1, pseudogene 10 Neighboring gene uncharacterized LOC134479085 Neighboring gene Fas associated factor 1 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Tokumoto YM, et al. Dev Biol, 2002 May 1. PMID 11969268
  2. p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. Pei XH, et al. Cancer Res, 2007 Apr 1. PMID 17409423
  3. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Guan KL, et al. Genes Dev, 1994 Dec 15. PMID 8001816
  4. Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome. Korshunov A, et al. Arch Pathol Lab Med, 2002 Jan. PMID 11800646
  5. Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Schreiber M, et al. Oncogene, 1999 Mar 4. PMID 10208428

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. posttranscriptional regulation
    Title: Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 4 inhibitor C
Names
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429663.1 → NP_001416592.1  cyclin-dependent kinase 4 inhibitor C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JYZ6, A6JYZ7, Q8R5G3, Q8R5G4

  2. NM_001429664.1 → NP_001416593.1  cyclin-dependent kinase 4 inhibitor C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JYZ6, A6JYZ7, Q8R5G3, Q8R5G4

  3. NM_131902.5 → NP_571977.1  cyclin-dependent kinase 4 inhibitor C

    See identical proteins and their annotated locations for NP_571977.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JYZ6, A6JYZ7, Q8R5G3, Q8R5G4
    Related
    ENSRNOP00000012088.4, ENSRNOT00000012088.9
    Conserved Domains (4) summary
    cd00204
    Location:37 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9 → 100
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:89 → 144
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:37 → 67
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    129639736..129645564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288321.1 → XP_063144391.1  cyclin-dependent kinase 4 inhibitor C isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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