Gata4 GATA binding protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gata4provided by RGD
Official Full Name: GATA binding protein 4provided by RGD
Primary source: RGD:2665
See related: EnsemblRapid:ENSRNOG00000010708 AllianceGenome:RGD:2665
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; positive regulation of BMP signaling pathway; and transdifferentiation. Predicted to be located in chromatin and nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study myocardial infarction. Biomarker of congenital heart disease and pulmonary hypertension. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 136.0), Testes (RPKM 66.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (41635572..41707252, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (37459601..37531291, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (46386703..46458679, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].
Title: [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].
GATA-binding protein 4 promotes neuroinflammation and cognitive impairment in Abeta1-42 fibril-infused rats through small nucleolar RNA host gene 1/miR-361-3p axis.
Title: GATA-binding protein 4 promotes neuroinflammation and cognitive impairment in Aβ(1-42) fibril-infused rats through small nucleolar RNA host gene 1/miR-361-3p axis.
Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis.
Title: Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis.
GATA4 promotes the senescence of nucleus pulposus cells via NF-kappaB pathway.
Title: GATA4 promotes the senescence of nucleus pulposus cells via NF-κB pathway.
LncRNA KCNQ1OT1 attenuates myocardial injury induced by hip fracture via regulating of miR-224-3p/GATA4 axis.
Title: LncRNA KCNQ1OT1 attenuates myocardial injury induced by hip fracture via regulating of miR-224-3p/GATA4 axis.
Loss of GATA4 C-Terminus by p.S335X Mutation Modulates Coronary Artery Vascular Smooth Muscle Cell Phenotype.
Title: Loss of GATA4 C-Terminus by p.S335X Mutation Modulates Coronary Artery Vascular Smooth Muscle Cell Phenotype.
Activation of GATA-binding protein 4 regulates monocyte chemoattractant protein-1 and chemotaxis in periodontal ligament cells.
Title: Activation of GATA-binding protein 4 regulates monocyte chemoattractant protein-1 and chemotaxis in periodontal ligament cells.
GATA4/6 regulate DHH transcription in rat adrenocortical autografts.
Title: GATA4/6 regulate DHH transcription in rat adrenocortical autografts.
Bioinformatics analysis and the dual-luciferase reporter assay demonstrated that miR-200c directly targeted the 3'-untranslated region of GATA-4, an important transcription factor for cardiomyocyte survival.
Title: Downregulation of miR-200c protects cardiomyocytes from hypoxia-induced apoptosis by targeting GATA-4.
downregulation of miR-122 alleviates cardiomyocyte hypoxia/reoxygenation injury through upregulation of GATA-4 expression.
Title: Downregulation of miR-122 attenuates hypoxia/reoxygenation (H/R)-induced myocardial cell apoptosis by upregulating GATA-4.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94862 (e-PCR)
- UniSTS:120108

Gata4 (e-PCR), detects polymorphism
- UniSTS:516400

Gata4 (e-PCR), detects polymorphism
- UniSTS:463410

Gata4 (e-PCR), detects polymorphism
- UniSTS:143177

Gata4 (e-PCR), detects polymorphism
- UniSTS:525914

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
contributes_to DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables NFAT protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables co-SMAD binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Sertoli cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrial septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrial septum primum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrial septum secundum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular canal development	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular valve formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within atrioventricular valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in cardiac right ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac septum development	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell growth involved in cardiac muscle cell development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to gonadotropin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic foregut morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocardial cushion development	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoderm formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intestinal epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung lobe formation	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of connective tissue replacement	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within seminiferous tubule development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction involved in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in transdifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tube morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum development	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor GATA-4

Names: DNA-binding protein GATA-GT2; GATA-binding factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144730.1 → NP_653331.1 transcription factor GATA-4

See identical proteins and their annotated locations for NP_653331.1

Status: PROVISIONAL

Source sequence(s)

L22761

UniProtKB/Swiss-Prot

P46152

UniProtKB/TrEMBL

A6K6F9

Related

ENSRNOP00000014320.3, ENSRNOT00000014320.7

Conserved Domains (2) summary

cd00202
Location:269 → 320

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

pfam05349
Location:1 → 204

GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

41635572..41707252 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274589.1 → XP_063130659.1 transcription factor GATA-4 isoform X2

UniProtKB/Swiss-Prot

P46152

UniProtKB/TrEMBL

A6K6F9
XM_017599788.3 → XP_017455277.1 transcription factor GATA-4 isoform X1

Conserved Domains (3) summary

smart00401
Location:268 → 315

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:270 → 321

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

pfam05349
Location:1 → 204

GATA-N; GATA-type transcription activator, N-terminal
XM_006252189.5 → XP_006252251.1 transcription factor GATA-4 isoform X1

Conserved Domains (3) summary

smart00401
Location:268 → 315

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:270 → 321

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

pfam05349
Location:1 → 204

GATA-N; GATA-type transcription activator, N-terminal