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Itpkb inositol-trisphosphate 3-kinase B [ Rattus norvegicus (Norway rat) ]

Gene ID: 54260, updated on 4-Jan-2025

Summary

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Official Symbol
Itpkbprovided by RGD
Official Full Name
inositol-trisphosphate 3-kinase Bprovided by RGD
Primary source
RGD:2932
See related
EnsemblRapid:ENSRNOG00000002969 AllianceGenome:RGD:2932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IP3K B
Summary
Predicted to enable inositol hexakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in cellular response to calcium ion; inositol phosphate metabolic process; and phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within several processes, including common myeloid progenitor cell proliferation; negative regulation of neutrophil apoptotic process; and regulation of hemopoiesis. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 121.6), Thymus (RPKM 107.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Itpkb in Genome Data Viewer
Location:
13q26
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (94601072..94696180)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (92069160..92164281)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (98615287..98710426)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553289 Neighboring gene uncharacterized LOC120096326 Neighboring gene uncharacterized LOC108352582 Neighboring gene stum, mechanosensory transduction mediator homolog Neighboring gene uncharacterized LOC120096327

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis. Yu JC, et al. Biochem J, 2005 Dec 15. PMID 16173920, Free PMC Article
  2. Isolation and sequence of a full length cDNA encoding a novel rat inositol 1,4,5-trisphosphate 3-kinase. Thomas S, et al. Biochim Biophys Acta, 1994 Jan 13. PMID 8312366
  3. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Jia Y, et al. Proc Natl Acad Sci U S A, 2008 Mar 25. PMID 18339802, Free PMC Article
  4. Identification and subcellular distribution of endogenous Ins(1,4,5)P(3) 3-kinase B in mouse tissues. Hascakova-Bartova R, et al. Biochem Biophys Res Commun, 2004 Oct 22. PMID 15381088
  5. Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Wen BG, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15064401, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The localization and activity of inositol 1,4,5-trisphosphate 3-kinase B(IP3KB) and its modulation by proteolysis are reported.
    Title: Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within common myeloid progenitor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol trisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inositol trisphosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within myeloid cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive thymic T cell selection ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within thymic T cell selection ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inositol-trisphosphate 3-kinase B
Names
IP3 3-kinase B
IP3K-B
inositol 1,4,5-trisphosphate 3-kinase B
insP 3-kinase B
NP_062185.2
XP_038946953.1
XP_038946954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019312.2 → NP_062185.2  inositol-trisphosphate 3-kinase B

    See identical proteins and their annotated locations for NP_062185.2

    Status: VALIDATED

    Source sequence(s)
    AA859368, AJ242781, BE113255, BF418570
    UniProtKB/Swiss-Prot
    P42335, Q91XW1
    UniProtKB/TrEMBL
    A6JGG8
    Related
    ENSRNOP00000004032.5, ENSRNOT00000004032.8
    Conserved Domains (1) summary
    pfam03770
    Location:714 → 925
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    94601072..94696180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091025.2 → XP_038946953.1  inositol-trisphosphate 3-kinase B isoform X1

  2. XM_039091026.2 → XP_038946954.1  inositol-trisphosphate 3-kinase B isoform X2

    Conserved Domains (1) summary
    pfam03770
    Location:99 → 310
    IPK; Inositol polyphosphate kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42335.3 GenPept UniProtKB/Swiss-Prot:P42335

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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