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Rgs3 regulator of G-protein signaling 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54293, updated on 27-Nov-2024

Summary

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Official Symbol
Rgs3provided by RGD
Official Full Name
regulator of G-protein signaling 3provided by RGD
Primary source
RGD:3566
See related
EnsemblRapid:ENSRNOG00000024501 AllianceGenome:RGD:3566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SRB-RGS
Summary
Predicted to enable GTPase regulator activity. Predicted to be involved in negative regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be active in nucleus and plasma membrane. Biomarker of bladder disease and lesion of sciatic nerve. Orthologous to human RGS3 (regulator of G protein signaling 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 61.3), Heart (RPKM 37.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rgs3 in Genome Data Viewer
Location:
5q24
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (81037588..81177446)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (76022038..76161895)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (78429017..78567281)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L31-like Neighboring gene similar to human chromosome 9 open reading frame 43 Neighboring gene DNA polymerase epsilon 3, accessory subunit Neighboring gene ubiquitin C-terminal hydrolase L3, pseudogene 2 Neighboring gene uncharacterized LOC120102895 Neighboring gene uncharacterized LOC120102896

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization and identification of a steroid receptor-binding protein, SRB-RGS. Ikeda M, et al. Biol Pharm Bull, 2007 Jun. PMID 17541154
  2. Molecular cloning and characterization of a steroid receptor-binding regulator of G-protein signaling protein cDNA. Ikeda M, et al. Gene, 2001 Aug 8. PMID 11595167
  3. High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons. Costigan M, et al. Mol Cell Neurosci, 2003 Sep. PMID 14550772
  4. Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells. Wang Q, et al. J Biol Chem, 2002 Jul 12. PMID 12006602
  5. Natriuretic peptides inhibit G protein activation. Mediation through cross-talk between cyclic GMP-dependent protein kinase and regulators of G protein-signaling proteins. Pedram A, et al. J Biol Chem, 2000 Mar 10. PMID 10702309

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRB-RGS was characterized and identified as a steroid receptor-binding protein.
    Title: Characterization and identification of a steroid receptor-binding protein, SRB-RGS.
  2. role in regulating mitogen-activated protein kinase activation in rat vascular smooth muscle cells
    Title: Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells.
  3. cell surface expression and regulation of GnRHR bearing a carboxyl-terminus is altered by RGS10, but not by RGS3, proteins
    Title: Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus.
  4. RGS3 is expressed at high levels in C-fiber primary sensory neurons in the adult rat dorsal root ganglion (DRG) and sciatic nerve transection results in a downregulation of this transcript.
    Title: High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93233

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 3
Names
regulator of G-protein signalling 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429681.1 → NP_001416610.1  regulator of G-protein signaling 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZT37

  2. NM_019340.2 → NP_062213.2  regulator of G-protein signaling 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6J7W3, G3V9Q2
    Related
    ENSRNOP00000055956.4, ENSRNOT00000059183.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    81037588..81177446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288323.1 → XP_063144393.1  regulator of G-protein signaling 3 isoform X6

    UniProtKB/TrEMBL
    A0A8L2QRC0, A6J7W2
    Related
    ENSRNOP00000055954.4, ENSRNOT00000059181.6

  2. XM_063288324.1 → XP_063144394.1  regulator of G-protein signaling 3 isoform X8

  3. XM_039110674.2 → XP_038966602.1  regulator of G-protein signaling 3 isoform X1

    UniProtKB/Swiss-Prot
    P49797, Q5RKK6, Q920Q9
    UniProtKB/TrEMBL
    A0A0G2K1B5
    Conserved Domains (4) summary
    cd08685
    Location:35 → 154
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd08713
    Location:1020 → 1133
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:578 → 802
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:195 → 268
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  4. XM_063288322.1 → XP_063144392.1  regulator of G-protein signaling 3 isoform X2

  5. XM_017593595.2 → XP_017449084.1  regulator of G-protein signaling 3 isoform X1

    UniProtKB/Swiss-Prot
    P49797, Q5RKK6, Q920Q9
    UniProtKB/TrEMBL
    A0A0G2K1B5
    Related
    ENSRNOP00000071774.1, ENSRNOT00000080744.3
    Conserved Domains (4) summary
    cd08685
    Location:35 → 154
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd08713
    Location:1020 → 1133
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:578 → 802
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:195 → 268
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  6. XM_006238260.5 → XP_006238322.1  regulator of G-protein signaling 3 isoform X3

    Related
    ENSRNOP00000081496.1, ENSRNOT00000107343.2
    Conserved Domains (7) summary
    cd08685
    Location:27 → 146
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd08713
    Location:1012 → 1125
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    COG0265
    Location:207 → 262
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:187 → 260
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09786
    Location:581 → 788
    CytochromB561_N; Cytochrome B561, N terminal
    pfam16228
    Location:531 → 706
    DUF4887; Domain of unknown function (DUF4887)
    cl09930
    Location:565 → 627
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

  7. XM_006238264.5 → XP_006238326.1  regulator of G-protein signaling 3 isoform X7

    Conserved Domains (2) summary
    cd08685
    Location:27 → 146
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd00992
    Location:187 → 260
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  8. XM_017593597.3 → XP_017449086.1  regulator of G-protein signaling 3 isoform X4

    UniProtKB/Swiss-Prot
    P49797, Q5RKK6, Q920Q9

  9. XM_039110676.2 → XP_038966604.1  regulator of G-protein signaling 3 isoform X5

    UniProtKB/Swiss-Prot
    P49797, Q5RKK6, Q920Q9
    Conserved Domains (4) summary
    cd08713
    Location:887 → 1000
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:445 → 669
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:62 → 135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14603
    Location:1 → 21
    C2; C2 domain

  10. XM_006238265.5 → XP_006238327.1  regulator of G-protein signaling 3 isoform X10

    See identical proteins and their annotated locations for XP_006238327.1

    UniProtKB/Swiss-Prot
    P49797
    Conserved Domains (2) summary
    COG0265
    Location:38 → 93
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:17 → 91
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  11. XM_063288325.1 → XP_063144395.1  regulator of G-protein signaling 3 isoform X9

    UniProtKB/TrEMBL
    A6J7W4

  12. XM_008763801.4 → XP_008762023.1  regulator of G-protein signaling 3 isoform X9

    See identical proteins and their annotated locations for XP_008762023.1

    UniProtKB/TrEMBL
    A6J7W4
    Conserved Domains (2) summary
    cd08713
    Location:445 → 558
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:3 → 227
    PHA03307; transcriptional regulator ICP4; Provisional

  13. XM_008763802.4 → XP_008762024.1  regulator of G-protein signaling 3 isoform X9

    See identical proteins and their annotated locations for XP_008762024.1

    UniProtKB/TrEMBL
    A6J7W4
    Conserved Domains (2) summary
    cd08713
    Location:445 → 558
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:3 → 227
    PHA03307; transcriptional regulator ICP4; Provisional

  14. XM_063288326.1 → XP_063144396.1  regulator of G-protein signaling 3 isoform X9

    UniProtKB/TrEMBL
    A6J7W4

  15. XM_063288327.1 → XP_063144397.1  regulator of G-protein signaling 3 isoform X11

    UniProtKB/TrEMBL
    A0A8I6AJG0
    Related
    ENSRNOP00000093735.1, ENSRNOT00000099793.2

  16. XM_063288328.1 → XP_063144398.1  regulator of G-protein signaling 3 isoform X12

    UniProtKB/TrEMBL
    A6J7W5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49797.2 GenPept UniProtKB/Swiss-Prot:P49797

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