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Cnn3 calponin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54321, updated on 27-Nov-2024

Summary

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Official Symbol
Cnn3provided by RGD
Official Full Name
calponin 3provided by RGD
Primary source
RGD:71044
See related
EnsemblRapid:ENSRNOG00000011559 AllianceGenome:RGD:71044
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables microtubule binding activity. Involved in negative regulation of ATP-dependent activity. Located in dendritic spine and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Orthologous to human CNN3 (calponin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 589.2), Adrenal (RPKM 558.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cnn3 in Genome Data Viewer
Location:
2q42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (212203661..212234772)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (209518948..209550107)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (225005069..225036179)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100935 Neighboring gene uncharacterized LOC103691685 Neighboring gene solute carrier family 44, member 3 Neighboring gene ribosomal protein S26, pseudogene 10 Neighboring gene uncharacterized LOC134485681

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Change in the shape and density of dendritic spines caused by overexpression of acidic calponin in cultured hippocampal neurons. Rami G, et al. Hippocampus, 2006. PMID 16358313
  2. Cloning and expression of a novel acidic calponin isoform from rat aortic vascular smooth muscle. Applegate D, et al. J Biol Chem, 1994 Apr 8. PMID 8144658
  3. Mapping the microtubule binding regions of calponin. Fattoum A, et al. Biochemistry, 2003 Feb 11. PMID 12564930
  4. Subcellular distribution of calponin and caldesmon in rat hippocampus. Agassandian C, et al. Brain Res, 2000 Dec 29. PMID 11134639
  5. Distribution of caldesmon and of the acidic isoform of calponin in cultured cerebellar neurons and in different regions of the rat brain: an immunofluorescence and confocal microscopy study. Represa A, et al. Exp Cell Res, 1995 Dec. PMID 7493632

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. h3/acidic calponin controls fibroblast migration by regulation of ERK1/2-mediated l-caldesmon phosphorylation.
    Title: h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells.
  2. acidic calponin is a key factor in the regulation of spine plasticity and synaptic activity
    Title: Change in the shape and density of dendritic spines caused by overexpression of acidic calponin in cultured hippocampal neurons.
  3. calponin undergoes a concomitant binding to both F-actin and microtubules by interaction at the former site with actin and at the second site with microtubules
    Title: Mapping the microtubule binding regions of calponin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in actin filament TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule TAS
Traceable Author Statement
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calponin-3
Names
acidic calponin h3
calponin 3, acidic

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019359.2 → NP_062232.1  calponin-3

    See identical proteins and their annotated locations for NP_062232.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P37397
    UniProtKB/TrEMBL
    A0A8I6AJV8, A6HVE0
    Related
    ENSRNOP00000093982.1, ENSRNOT00000104611.2
    Conserved Domains (2) summary
    pfam00402
    Location:164 → 188
    Calponin; Calponin family repeat
    cd21284
    Location:23 → 133
    CH_CNN3; calponin homology (CH) domain found in calponin-3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    212203661..212234772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102991.2 → XP_038958919.1  calponin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJV8
    Conserved Domains (2) summary
    pfam00402
    Location:123 → 147
    Calponin; Calponin family repeat
    cl00030
    Location:1 → 92
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37397.1 GenPept UniProtKB/Swiss-Prot:P37397

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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