Irx5 Iroquois homeobox 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irx5provided by MGI
Official Full Name: Iroquois homeobox 5provided by MGI
Primary source: MGI:MGI:1859086
See related: Ensembl:ENSMUSG00000031737 AllianceGenome:MGI:1859086
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within neuron differentiation; regulation of gene expression; and regulation of heart rate. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Orthologous to human IRX5 (iroquois homeobox 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in lung adult (RPKM 17.2), limb E14.5 (RPKM 13.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 44.93 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (93084424..93088084)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (92357796..92361456)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IRX5 suppresses osteogenic differentiation of hBMSCs by inhibiting protein synthesis.
Title: IRX5 suppresses osteogenic differentiation of hBMSCs by inhibiting protein synthesis.
IRX5 promotes DNA damage repair and activation of hair follicle stem cells.
Title: IRX5 promotes DNA damage repair and activation of hair follicle stem cells.
Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities.
Title: Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities.
Irx5 and transient outward K(+) currents contribute to transmural contractile heterogeneities in the mouse ventricle.
Title: Irx5 and transient outward K(+) currents contribute to transmural contractile heterogeneities in the mouse ventricle.
IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mousedagger.
Title: IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mouse†.
IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis.
Title: IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis.
Irx3 and Irx5 in Ins2-Cre(+) cells regulate hypothalamic postnatal neurogenesis and leptin response.
Title: Irx3 and Irx5 in Ins2-Cre(+) cells regulate hypothalamic postnatal neurogenesis and leptin response.
Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Title: Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
IRX3/5 regulate mitotic chromatid segregation and limb bud shape.
Title: IRX3/5 regulate mitotic chromatid segregation and limb bud shape.
Canonical Wnt/beta-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads.
Title: Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

Irx5 (e-PCR), detects polymorphism
- UniSTS:532301

Irx5 (e-PCR), detects polymorphism
- UniSTS:515969

PMC310936P4 (e-PCR)
- UniSTS:272821

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in gonad development	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron maturation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal bipolar neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: iroquois-class homeodomain protein IRX-5

Names: homeodomain protein IRXB2; iroquois homeobox protein 5; iroquois related homeobox 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018826.2 → NP_061296.1 iroquois-class homeodomain protein IRX-5

See identical proteins and their annotated locations for NP_061296.1

Status: VALIDATED

Source sequence(s)

BC056994

Consensus CDS

CCDS22522.1

UniProtKB/Swiss-Prot

Q80WV4, Q9JKQ4, Q9JLL5

UniProtKB/TrEMBL

A0A1B0GR17

Related

ENSMUSP00000034184.10, ENSMUST00000034184.12

Conserved Domains (2) summary

smart00548
Location:328 → 345

IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function

pfam05920
Location:130 → 169

Homeobox_KN; Homeobox KN domain