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Arhgap27 Rho GTPase activating protein 27 [ Mus musculus (house mouse) ]

Gene ID: 544817, updated on 27-Nov-2024

Summary

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Official Symbol
Arhgap27provided by MGI
Official Full Name
Rho GTPase activating protein 27provided by MGI
Primary source
MGI:MGI:1916903
See related
Ensembl:ENSMUSG00000034255 AllianceGenome:MGI:1916903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sh3d20; Gm21552; 2310069I04Rik; 5730442P18Rik
Summary
Predicted to enable GTPase activator activity and SH3 domain binding activity. Predicted to be involved in Rho protein signal transduction and receptor-mediated endocytosis. Predicted to be located in endosome. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain; sensory organ; and skeleton. Orthologous to human ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 40.0), duodenum adult (RPKM 33.5) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgap27 in Genome Data Viewer
Location:
11; 11 E1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103222310..103254518, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103331484..103363692, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 32 Neighboring gene predicted gene, 51920 Neighboring gene mitogen-activated protein kinase kinase kinase 14 Neighboring gene predicted gene, 34823 Neighboring gene STARR-positive B cell enhancer ABC_E10718 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:103128947-103129269 Neighboring gene STARR-seq mESC enhancer starr_30841 Neighboring gene STARR-seq mESC enhancer starr_30842 Neighboring gene STARR-positive B cell enhancer ABC_E3026 Neighboring gene Rho GTPase activating protein 27, opposite strand 3 Neighboring gene STARR-positive B cell enhancer ABC_E8459 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 1 Neighboring gene STARR-seq mESC enhancer starr_30848 Neighboring gene STARR-positive B cell enhancer ABC_E9376 Neighboring gene STARR-positive B cell enhancer ABC_E3027 Neighboring gene predicted gene, 39397

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. Peck J, et al. FEBS Lett, 2002 Sep 25. PMID 12297274
  2. Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation. Gaidos G, et al. J Cell Sci, 2007 Jul 15. PMID 17606992
  3. CD2AP regulates SUMOylation of CIN85 in podocytes. Tossidou I, et al. Mol Cell Biol, 2012 Mar. PMID 22203040, Free PMC Article
  4. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  5. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC62780, MGC169916, MGC169917

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 27
Names
CIN85-associated multi-domain-containing Rho GTPase-activating protein 1
SH3 domain containing 20
rho-type GTPase-activating protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205236.1 → NP_001192165.1  rho GTPase-activating protein 27 isoform 1

    See identical proteins and their annotated locations for NP_001192165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL662804, AL772325
    Consensus CDS
    CCDS56815.1
    UniProtKB/Swiss-Prot
    A2AB59, Q3V366, Q4V9V5
    Related
    ENSMUSP00000102639.2, ENSMUST00000107024.9
    Conserved Domains (6) summary
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    COG5104
    Location:241 → 328
    PRP40; Splicing factor [RNA processing and modification]
    PRK12323
    Location:68 → 249
    PRK12323; DNA polymerase III subunit gamma/tau
    cd04403
    Location:675 → 861
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:480 → 594
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:248 → 278
    WW; WW domain

  2. NM_133715.5 → NP_598476.2  rho GTPase-activating protein 27 isoform 2

    See identical proteins and their annotated locations for NP_598476.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate internal promoter, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK046763, AL662804, BY552449
    Consensus CDS
    CCDS25517.1
    UniProtKB/Swiss-Prot
    A2AB59
    Related
    ENSMUSP00000039427.8, ENSMUST00000041385.14
    Conserved Domains (4) summary
    cd04403
    Location:476 → 662
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:281 → 395
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:281 → 394
    PH; PH domain
    pfam00397
    Location:49 → 79
    WW; WW domain

  3. NM_183288.3 → NP_899111.2  rho GTPase-activating protein 27 isoform 3

    See identical proteins and their annotated locations for NP_899111.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several 3' exons and contains an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is significantly shorter than isoform 1.
    Source sequence(s)
    AL772325, CJ068176
    Consensus CDS
    CCDS36350.1
    UniProtKB/TrEMBL
    A2AKN5, B2RR95
    Related
    ENSMUSP00000102637.3, ENSMUST00000092557.6
    Conserved Domains (1) summary
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    103222310..103254518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156858.1 → XP_036012751.1  rho GTPase-activating protein 27 isoform X3

    Conserved Domains (6) summary
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    COG5104
    Location:241 → 328
    PRP40; Splicing factor [RNA processing and modification]
    PRK12323
    Location:68 → 249
    PRK12323; DNA polymerase III subunit gamma/tau
    cd04403
    Location:620 → 806
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:425 → 539
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:248 → 278
    WW; WW domain

  2. XM_036156857.1 → XP_036012750.1  rho GTPase-activating protein 27 isoform X2

    Conserved Domains (6) summary
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    COG5104
    Location:241 → 328
    PRP40; Splicing factor [RNA processing and modification]
    PRK12323
    Location:68 → 249
    PRK12323; DNA polymerase III subunit gamma/tau
    cd04403
    Location:647 → 833
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:452 → 566
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:248 → 278
    WW; WW domain

  3. XM_036156856.1 → XP_036012749.1  rho GTPase-activating protein 27 isoform X1

    UniProtKB/Swiss-Prot
    A2AB59, Q3V366, Q4V9V5
    Conserved Domains (6) summary
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    COG5104
    Location:241 → 328
    PRP40; Splicing factor [RNA processing and modification]
    PRK12323
    Location:68 → 249
    PRK12323; DNA polymerase III subunit gamma/tau
    cd04403
    Location:675 → 861
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:480 → 594
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:248 → 278
    WW; WW domain

  4. XM_006533754.5 → XP_006533817.1  rho GTPase-activating protein 27 isoform X4

    Conserved Domains (4) summary
    COG5104
    Location:56 → 143
    PRP40; Splicing factor [RNA processing and modification]
    cd04403
    Location:490 → 676
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:295 → 409
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:63 → 93
    WW; WW domain

RNA

  1. XR_001780030.3 RNA Sequence

    Related
    ENSMUST00000116102.9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AB59.1 GenPept UniProtKB/Swiss-Prot:A2AB59

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