Kalrn kalirin, RhoGEF kinase [ Mus musculus (house mouse) ]

Gene ID: 545156, updated on 27-Nov-2024

Summary

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Official Symbol: Kalrnprovided by MGI
Official Full Name: kalirin, RhoGEF kinaseprovided by MGI
Primary source: MGI:MGI:2685385
See related: Ensembl:ENSMUSG00000061751 AllianceGenome:MGI:2685385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DUET; TRAD; Gm539; Hapip; 2210407G14Rik; E530005C20Rik
Summary: Predicted to enable enzyme binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including learning or memory; maternal behavior; and maternal process involved in parturition. Predicted to be located in several cellular components, including neuronal cell body; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic density; and presynapse. Predicted to be extrinsic component of membrane. Is expressed in cerebral cortex ventricular layer; cortical plate; dorsal root ganglion; and spinal cord. Human ortholog(s) of this gene implicated in cerebral atherosclerosis; cerebral infarction; and coronary artery disease. Orthologous to human KALRN (kalirin RhoGEF kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 11.3), frontal lobe adult (RPKM 7.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

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See Kalrn in Genome Data Viewer

Location:: 16 B3; 16 24.27 cM

Exon count:: 69

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (33789443..34393647, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (33969073..34573277, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kalirin mediates Rac1 activation downstream of calcium/calmodulin-dependent protein kinase II to stimulate glucose uptake during muscle contraction.
Title: Kalirin mediates Rac1 activation downstream of calcium/calmodulin-dependent protein kinase II to stimulate glucose uptake during muscle contraction.
KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
Title: KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.
Title: Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.
Kalirin reduction in APPswe/PSEN1dE9 mice significantly attenuated psychosis-associated behavior at 12 months of age without changing spatial memory performance.
Title: Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.
Kalirin-7 plays a prominent role in nociceptive sensitization via activity-dependent modulation of spinal synapses.
Title: A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
lack of Kalrn expression in POMC cells closely mimicked the effects of global Kalrn knockout on anxiety-like behavior and passive avoidance conditioning
Title: Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.
Kal7 may allow coordination of the many signaling pathways contributing to dendritic spine morphogenesis.
Title: Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.
Kalirin may play a role in paracrine and/or endocrine signaling events that control skeletal bone remodeling and the maintenance of bone mass.
Title: The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
Kalerin-7 knock-out mice exhibit increased self-administration of cocaine compared to wild-type mice.
Title: Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration.
Many of the widespread and diverse deficits observed both within and outside of the nervous system when expression of Kalrn is eliminated may reflect its role in secretory granule function and its expression outside of the nervous system.
Title: Kalrn plays key roles within and outside of the nervous system.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa38e2.seq (e-PCR)
- UniSTS:160563

AU049016 (e-PCR)
- UniSTS:145464

BB298680 (e-PCR)
- UniSTS:209211

RH137364 (e-PCR)
- UniSTS:219452

ha3112 (e-PCR)
- UniSTS:515652

NoName (e-PCR)
- UniSTS:224334

AV235988 (e-PCR)
- UniSTS:165996

ha2170 (e-PCR)
- UniSTS:515496

NoName (e-PCR)
- UniSTS:237498

NoName (e-PCR)
- UniSTS:224740

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NMDA selective glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maternal behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maternal process involved in parturition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kalirin

Names: huntingtin-associated protein interacting protein (duo); protein Duo; serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine kinase with Dbl- and pleckstrin homology domains; serine/threonine-protein kinase with Dbl- and pleckstrin homology domain

NP_001157740.1

EC 2.7.11.1

NP_796331.2

EC 2.7.11.1

XP_006522426.1

EC 2.7.11.1

XP_006522427.1

EC 2.7.11.1

XP_006522433.1

EC 2.7.11.1

XP_006522443.1

EC 2.7.11.1

XP_006522444.1

EC 2.7.11.1

XP_006522445.1

EC 2.7.11.1

XP_006522446.1

EC 2.7.11.1

XP_006522448.1

EC 2.7.11.1

XP_006522449.1

EC 2.7.11.1

XP_011244253.1

EC 2.7.11.1

XP_011244254.1

EC 2.7.11.1

XP_011244255.1

EC 2.7.11.1

XP_011244256.1

EC 2.7.11.1

XP_011244257.1

EC 2.7.11.1

XP_011244258.1

EC 2.7.11.1

XP_011244259.1

EC 2.7.11.1

XP_011244260.1

EC 2.7.11.1

XP_011244261.1

EC 2.7.11.1

XP_011244262.1

EC 2.7.11.1

XP_011244263.1

EC 2.7.11.1

XP_011244265.1

EC 2.7.11.1

XP_011244267.1

EC 2.7.11.1

XP_011244268.1

EC 2.7.11.1

XP_011244269.1

EC 2.7.11.1

XP_011244270.1

EC 2.7.11.1

XP_017172560.1

EC 2.7.11.1

XP_017172561.1

EC 2.7.11.1

XP_017172562.1

EC 2.7.11.1

XP_017172563.1

EC 2.7.11.1

XP_017172564.1

EC 2.7.11.1

XP_017172565.1

EC 2.7.11.1

XP_017172566.1

EC 2.7.11.1

XP_017172568.1

EC 2.7.11.1

XP_017172569.1

EC 2.7.11.1

XP_017172570.1

EC 2.7.11.1

XP_017172571.1

EC 2.7.11.1

XP_030105050.1

EC 2.7.11.1

XP_030105051.1

EC 2.7.11.1

XP_030105052.1

EC 2.7.11.1

XP_036015907.1

EC 2.7.11.1

XP_036015909.1

EC 2.7.11.1

XP_036015910.1

EC 2.7.11.1

XP_036015912.1

EC 2.7.11.1

XP_036015913.1

EC 2.7.11.1

XP_036015914.1

EC 2.7.11.1

XP_036015916.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164268.1 → NP_001157740.1 kalirin isoform 2

See identical proteins and their annotated locations for NP_001157740.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK147518, BC157950

Consensus CDS

CCDS49836.1

UniProtKB/TrEMBL

B1B1A7

Related

ENSMUSP00000110611.3, ENSMUST00000114960.9

Conserved Domains (5) summary

smart00150
Location:1126 → 1226

SPEC; Spectrin repeats

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1275 → 1445

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1120

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1452 → 1574

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
NM_177357.3 → NP_796331.2 kalirin isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).

Source sequence(s)

AC154524, AC154588, AC165079, CT010573

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Related

ENSMUSP00000076088.6, ENSMUST00000076810.12

Conserved Domains (17) summary

cd00096
Location:2478 → 2552

Ig; Immunoglobulin domain

smart00150
Location:1126 → 1226

SPEC; Spectrin repeats

cd11852
Location:1640 → 1699

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2314 → 2370

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2674 → 2928

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2559 → 2650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1275 → 1445

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1120

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2242 → 2294

Extensin_2; Extensin-like region

pfam07679
Location:2461 → 2555

I-set; Immunoglobulin I-set domain

cd13240
Location:1452 → 1574

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2096 → 2230

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2680 → 2927

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1485 → 1570

PH; PH domain

pfam00621
Location:1922 → 2092

RhoGEF; RhoGEF domain

pfam16609
Location:1697 → 1921

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

33789443..34393647 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245955.2 → XP_011244257.1 kalirin isoform X6

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1137 → 1237

SPEC; Spectrin repeats

cd11852
Location:1651 → 1710

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2325 → 2381

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2570 → 2661

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1131

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2253 → 2305

Extensin_2; Extensin-like region

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2107 → 2241

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2691 → 2938

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1933 → 2102

RhoGEF; RhoGEF domain

pfam07679
Location:2472 → 2566

I-set; Immunoglobulin I-set domain

pfam16609
Location:1708 → 1923

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_006522386.4 → XP_006522449.1 kalirin isoform X45

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1121 → 1221

SPEC; Spectrin repeats

cd11852
Location:1635 → 1694

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2309 → 2365

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2534 → 2625

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1270 → 1440

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:886 → 1115

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2237 → 2289

Extensin_2; Extensin-like region

cd13240
Location:1447 → 1569

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2091 → 2225

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2655 → 2902

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1917 → 2086

RhoGEF; RhoGEF domain

pfam07679
Location:2436 → 2530

I-set; Immunoglobulin I-set domain

pfam16609
Location:1692 → 1907

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_006522370.4 → XP_006522433.1 kalirin isoform X11

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1121 → 1221

SPEC; Spectrin repeats

cd11852
Location:1635 → 1694

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2309 → 2365

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2554 → 2645

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1270 → 1440

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:886 → 1115

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2237 → 2289

Extensin_2; Extensin-like region

cd13240
Location:1447 → 1569

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2091 → 2225

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2675 → 2922

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1917 → 2086

RhoGEF; RhoGEF domain

pfam07679
Location:2456 → 2550

I-set; Immunoglobulin I-set domain

pfam16609
Location:1692 → 1907

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_036160016.1 → XP_036015909.1 kalirin isoform X16

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1130 → 1230

SPEC; Spectrin repeats

cd11852
Location:1644 → 1703

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2286 → 2342

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2531 → 2622

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1279 → 1449

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:545 → 761

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1456 → 1578

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2069 → 2203

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2652 → 2899

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1895 → 2064

RhoGEF; RhoGEF domain

pfam07679
Location:2433 → 2527

I-set; Immunoglobulin I-set domain

pfam16609
Location:1701 → 1892

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2425 → 2428

Ig; Ig strand A [structural motif]
XM_011245956.3 → XP_011244258.1 kalirin isoform X9

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1130 → 1230

SPEC; Spectrin repeats

cd11852
Location:1644 → 1703

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2318 → 2374

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2563 → 2654

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1279 → 1449

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:545 → 761

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2246 → 2298

Extensin_2; Extensin-like region

cd13240
Location:1456 → 1578

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2100 → 2234

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2684 → 2931

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1926 → 2095

RhoGEF; RhoGEF domain

pfam07679
Location:2465 → 2559

I-set; Immunoglobulin I-set domain

pfam16609
Location:1701 → 1916

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_006522364.4 → XP_006522427.1 kalirin isoform X8

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1134 → 1234

SPEC; Spectrin repeats

cd11852
Location:1648 → 1707

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2322 → 2378

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2567 → 2658

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1283 → 1453

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1128

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2250 → 2302

Extensin_2; Extensin-like region

cd13240
Location:1460 → 1582

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2104 → 2238

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2688 → 2935

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1930 → 2099

RhoGEF; RhoGEF domain

pfam07679
Location:2469 → 2563

I-set; Immunoglobulin I-set domain

pfam16609
Location:1705 → 1920

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245961.3 → XP_011244263.1 kalirin isoform X14

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2299 → 2355

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2544 → 2635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2227 → 2279

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2081 → 2215

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2665 → 2912

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1907 → 2076

RhoGEF; RhoGEF domain

pfam07679
Location:2446 → 2540

I-set; Immunoglobulin I-set domain

pfam16609
Location:1714 → 1862

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_036160014.1 → XP_036015907.1 kalirin isoform X4

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2329 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2574 → 2665

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2112 → 2246

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2695 → 2942

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1938 → 2107

RhoGEF; RhoGEF domain

pfam07679
Location:2476 → 2570

I-set; Immunoglobulin I-set domain

pfam16609
Location:1714 → 1895

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2468 → 2471

Ig; Ig strand A [structural motif]
XM_011245952.3 → XP_011244254.1 kalirin isoform X2

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2330 → 2386

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2575 → 2666

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2258 → 2310

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2112 → 2246

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2696 → 2943

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1938 → 2107

RhoGEF; RhoGEF domain

pfam07679
Location:2477 → 2571

I-set; Immunoglobulin I-set domain

pfam16609
Location:1714 → 1928

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317071.2 → XP_017172560.1 kalirin isoform X15

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2299 → 2355

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2544 → 2635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2228 → 2280

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2082 → 2216

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2665 → 2912

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1908 → 2077

RhoGEF; RhoGEF domain

pfam07679
Location:2446 → 2540

I-set; Immunoglobulin I-set domain

pfam16609
Location:1714 → 1863

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245960.3 → XP_011244262.1 kalirin isoform X13

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2300 → 2356

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2545 → 2636

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2228 → 2280

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2082 → 2216

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2666 → 2913

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1908 → 2077

RhoGEF; RhoGEF domain

pfam07679
Location:2447 → 2541

I-set; Immunoglobulin I-set domain

pfam16609
Location:1714 → 1863

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245953.3 → XP_011244255.1 kalirin isoform X3

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2330 → 2386

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2575 → 2666

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2259 → 2311

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2696 → 2943

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam07679
Location:2477 → 2571

I-set; Immunoglobulin I-set domain

pfam16609
Location:1714 → 1929

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245957.3 → XP_011244259.1 kalirin isoform X10

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2331 → 2387

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2556 → 2647

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2259 → 2311

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2677 → 2924

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam07679
Location:2458 → 2552

I-set; Immunoglobulin I-set domain

pfam16609
Location:1714 → 1929

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245951.3 → XP_011244253.1 kalirin isoform X1

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2331 → 2387

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2576 → 2667

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2259 → 2311

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2697 → 2944

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam07679
Location:2478 → 2572

I-set; Immunoglobulin I-set domain

pfam16609
Location:1714 → 1929

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_006522363.5 → XP_006522426.1 kalirin isoform X7

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1135 → 1235

SPEC; Spectrin repeats

cd11852
Location:1649 → 1708

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2323 → 2379

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2568 → 2659

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1284 → 1454

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1129

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2251 → 2303

Extensin_2; Extensin-like region

cd13240
Location:1461 → 1583

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2105 → 2239

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2689 → 2936

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1931 → 2100

RhoGEF; RhoGEF domain

pfam07679
Location:2470 → 2564

I-set; Immunoglobulin I-set domain

pfam16609
Location:1706 → 1921

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245954.4 → XP_011244256.1 kalirin isoform X5

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2326 → 2382

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2571 → 2662

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2254 → 2306

Extensin_2; Extensin-like region

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2108 → 2242

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2692 → 2939

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1934 → 2103

RhoGEF; RhoGEF domain

pfam07679
Location:2473 → 2567

I-set; Immunoglobulin I-set domain

pfam16609
Location:1709 → 1924

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245959.3 → XP_011244261.1 kalirin isoform X12

See identical proteins and their annotated locations for XP_011244261.1

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1117 → 1217

SPEC; Spectrin repeats

cd11852
Location:1631 → 1690

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2305 → 2361

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:21 → 159

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2550 → 2641

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1266 → 1436

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:873 → 1111

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2233 → 2285

Extensin_2; Extensin-like region

cd13240
Location:1443 → 1565

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2087 → 2221

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2671 → 2918

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1913 → 2082

RhoGEF; RhoGEF domain

pfam07679
Location:2452 → 2546

I-set; Immunoglobulin I-set domain

pfam16609
Location:1688 → 1903

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245958.3 → XP_011244260.1 kalirin isoform X12

See identical proteins and their annotated locations for XP_011244260.1

UniProtKB/Swiss-Prot

A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9

Conserved Domains (14) summary

smart00150
Location:1117 → 1217

SPEC; Spectrin repeats

cd11852
Location:1631 → 1690

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2305 → 2361

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:21 → 159

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2550 → 2641

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1266 → 1436

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:873 → 1111

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2233 → 2285

Extensin_2; Extensin-like region

cd13240
Location:1443 → 1565

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2087 → 2221

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2671 → 2918

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1913 → 2082

RhoGEF; RhoGEF domain

pfam07679
Location:2452 → 2546

I-set; Immunoglobulin I-set domain

pfam16609
Location:1688 → 1903

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_006522381.1 → XP_006522444.1 kalirin isoform X33

Conserved Domains (13) summary

smart00150
Location:481 → 581

SPEC; Spectrin repeats

cd11852
Location:995 → 1054

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:1669 → 1725

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

cd00063
Location:1914 → 2005

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:630 → 800

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:237 → 475

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:1597 → 1649

Extensin_2; Extensin-like region

cd13240
Location:807 → 929

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:1451 → 1585

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2035 → 2282

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1277 → 1446

RhoGEF; RhoGEF domain

pfam07679
Location:1816 → 1910

I-set; Immunoglobulin I-set domain

pfam16609
Location:1052 → 1267

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_036160023.1 → XP_036015916.1 kalirin isoform X32

Conserved Domains (13) summary

smart00150
Location:485 → 585

SPEC; Spectrin repeats

cd11852
Location:999 → 1058

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:1673 → 1729

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

cd00063
Location:1918 → 2009

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:634 → 804

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:250 → 479

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:811 → 933

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:1455 → 1589

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2039 → 2286

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1281 → 1450

RhoGEF; RhoGEF domain

pfam07679
Location:1820 → 1914

I-set; Immunoglobulin I-set domain

pfam16609
Location:1056 → 1238

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:1812 → 1815

Ig; Ig strand A [structural motif]
XM_006522380.1 → XP_006522443.1 kalirin isoform X31

Conserved Domains (14) summary

smart00150
Location:494 → 594

SPEC; Spectrin repeats

cd11852
Location:1008 → 1067

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:1682 → 1738

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

cd00063
Location:1927 → 2018

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:643 → 813

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:250 → 488

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:1610 → 1662

Extensin_2; Extensin-like region

cd13240
Location:820 → 942

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:1464 → 1598

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2048 → 2295

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

cl02488
Location:5 → 249

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00621
Location:1290 → 1459

RhoGEF; RhoGEF domain

pfam07679
Location:1829 → 1923

I-set; Immunoglobulin I-set domain

pfam16609
Location:1065 → 1280

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_006522385.5 → XP_006522448.1 kalirin isoform X39

UniProtKB/TrEMBL

D3Z4R2

Related

ENSMUSP00000110624.2, ENSMUST00000114973.9

Conserved Domains (7) summary

cd11853
Location:627 → 683

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

cd00063
Location:872 → 963

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13241
Location:409 → 543

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:993 → 1240

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:235 → 404

RhoGEF; RhoGEF domain

pfam07679
Location:774 → 868

I-set; Immunoglobulin I-set domain

pfam16609
Location:23 → 225

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317077.3 → XP_017172566.1 kalirin isoform X40

Conserved Domains (7) summary

cd11853
Location:626 → 682

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

cd00063
Location:871 → 962

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13241
Location:409 → 543

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:992 → 1239

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:235 → 404

RhoGEF; RhoGEF domain

pfam07679
Location:773 → 867

I-set; Immunoglobulin I-set domain

pfam16609
Location:23 → 225

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_036160017.1 → XP_036015910.1 kalirin isoform X18

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2331 → 2387

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:753 → 999

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1896

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_036160019.1 → XP_036015912.1 kalirin isoform X19

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2330 → 2386

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:753 → 999

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1896

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245963.3 → XP_011244265.1 kalirin isoform X17

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2331 → 2387

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2259 → 2311

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1929

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_030249191.1 → XP_030105051.1 kalirin isoform X28

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (12) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2299 → 2355

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2227 → 2279

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2081 → 2215

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:753 → 999

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1907 → 2076

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1862

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_036160020.1 → XP_036015913.1 kalirin isoform X23

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (10) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2330 → 2386

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2112 → 2246

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1938 → 2107

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1895

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_036160021.1 → XP_036015914.1 kalirin isoform X27

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2300 → 2356

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2082 → 2216

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:753 → 999

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1908 → 2077

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1905

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245965.3 → XP_011244267.1 kalirin isoform X20

UniProtKB/TrEMBL

F6QYT9

Related

ENSMUSP00000116188.2, ENSMUST00000142817.8

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2331 → 2387

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2259 → 2311

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1929

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245966.3 → XP_011244268.1 kalirin isoform X21

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2331 → 2387

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2259 → 2311

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1929

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317074.2 → XP_017172563.1 kalirin isoform X30

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (12) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2298 → 2354

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2227 → 2279

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2081 → 2215

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:753 → 999

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1907 → 2076

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1862

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_030249190.1 → XP_030105050.1 kalirin isoform X25

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2329 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2258 → 2310

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2112 → 2246

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1938 → 2107

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1928

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_030249192.1 → XP_030105052.1 kalirin isoform X29

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (12) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2299 → 2355

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2228 → 2280

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2082 → 2216

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:753 → 999

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1908 → 2077

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1863

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317072.3 → XP_017172561.1 kalirin isoform X22

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2330 → 2386

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2259 → 2311

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1929

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_011245967.3 → XP_011244269.1 kalirin isoform X24

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2330 → 2386

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2259 → 2311

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2113 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1939 → 2108

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1929

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317073.2 → XP_017172562.1 kalirin isoform X26

UniProtKB/TrEMBL

F6QYT9

Conserved Domains (12) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1657 → 1716

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2329 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam04554
Location:2258 → 2310

Extensin_2; Extensin-like region

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2112 → 2246

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:753 → 999

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1938 → 2107

RhoGEF; RhoGEF domain

pfam16609
Location:1714 → 1928

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317082.3 → XP_017172571.1 kalirin isoform X44

UniProtKB/TrEMBL

D3Z534

Conserved Domains (5) summary

cd11853
Location:594 → 650

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

pfam04554
Location:523 → 575

Extensin_2; Extensin-like region

cd13241
Location:377 → 511

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:203 → 372

RhoGEF; RhoGEF domain

pfam16609
Location:23 → 158

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317080.3 → XP_017172569.1 kalirin isoform X42

UniProtKB/TrEMBL

D3Z534

Conserved Domains (5) summary

cd11853
Location:595 → 651

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

pfam04554
Location:523 → 575

Extensin_2; Extensin-like region

cd13241
Location:377 → 511

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:203 → 372

RhoGEF; RhoGEF domain

pfam16609
Location:23 → 158

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317081.3 → XP_017172570.1 kalirin isoform X43

UniProtKB/TrEMBL

D3Z534

Conserved Domains (5) summary

cd11853
Location:595 → 651

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

pfam04554
Location:524 → 576

Extensin_2; Extensin-like region

cd13241
Location:378 → 512

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:204 → 373

RhoGEF; RhoGEF domain

pfam16609
Location:23 → 159

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317079.3 → XP_017172568.1 kalirin isoform X41

UniProtKB/TrEMBL

D3Z534

Related

ENSMUSP00000110615.2, ENSMUST00000114964.8

Conserved Domains (5) summary

cd11853
Location:596 → 652

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

pfam04554
Location:524 → 576

Extensin_2; Extensin-like region

cd13241
Location:378 → 512

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:204 → 373

RhoGEF; RhoGEF domain

pfam16609
Location:23 → 159

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017317076.3 → XP_017172565.1 kalirin isoform X38

UniProtKB/TrEMBL

B1B1A7

Conserved Domains (5) summary

smart00150
Location:1121 → 1221

SPEC; Spectrin repeats

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1270 → 1440

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:886 → 1115

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1447 → 1569

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
XM_017317075.3 → XP_017172564.1 kalirin isoform X37

UniProtKB/TrEMBL

B1B1A7

Conserved Domains (5) summary

smart00150
Location:1130 → 1230

SPEC; Spectrin repeats

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1279 → 1449

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:545 → 761

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1456 → 1578

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
XM_006522383.5 → XP_006522446.1 kalirin isoform X36

UniProtKB/TrEMBL

B1B1A7

Conserved Domains (5) summary

smart00150
Location:1134 → 1234

SPEC; Spectrin repeats

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1283 → 1453

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1128

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1460 → 1582

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
XM_011245968.4 → XP_011244270.1 kalirin isoform X34

UniProtKB/TrEMBL

B1B1A7

Conserved Domains (6) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

smart00516
Location:47 → 185

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1292 → 1462

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:899 → 1137

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1469 → 1591

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

TIGR02168
Location:753 → 999

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006522382.5 → XP_006522445.1 kalirin isoform X35

UniProtKB/TrEMBL

B1B1A7

Related

ENSMUSP00000087084.6, ENSMUST00000089655.12

Conserved Domains (5) summary

smart00150
Location:1135 → 1235

SPEC; Spectrin repeats

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1284 → 1454

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1129

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1461 → 1583

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1