Rhox3g reproductive homeobox 3G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhox3gprovided by MGI
Official Full Name: reproductive homeobox 3Gprovided by MGI
Primary source: MGI:MGI:3770313
See related: Ensembl:ENSMUSG00000080933 AllianceGenome:MGI:3770313
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rhox3f; Rhox3.7; Rhox3g-ps
Summary: This gene is a member of the reproductive homeobox X-linked family (Rhox), which forms part of the superfamily of Homeobox transcription factors. Rhox family members are thought to contribute to early embryo development as well as female and male gametogenesis because they are expressed during embryogenesis and in reproductive tissues. In the mouse, this family expanded to form gene clusters categorized into alpha, beta and gamma, depending on chromosomal locations. Rhox3 paralogs are in the alpha cluster and are reported to be more highly expressed in testes compared to ovaries. This protein is missing a portion of the N-terminus compared to other Rhox3 paralogs, so its functional capacity is unclear. [provided by RefSeq, Dec 2012]
Annotation information: Note: This gene was previously named "Rhox3f" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox3.7" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox3g. [26 Apr 2013]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: X A3.3; X 21.93 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (36805084..36809792, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (37623431..37628139, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Dppa3 (e-PCR), detects polymorphism
- UniSTS:254292

NoName (e-PCR)
- UniSTS:491936

Dppa3 (e-PCR), detects polymorphism
- UniSTS:526817

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: reproductive homeobox 3G

Names: reproductive homeobox 3F; reproductive homeobox 3G, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145406.3 → NP_001138878.1 reproductive homeobox 3G

See identical proteins and their annotated locations for NP_001138878.1

Status: REVIEWED

Source sequence(s)

BC147475

Consensus CDS

CCDS72366.1

UniProtKB/TrEMBL

B9EJQ9, Q6YI58

Related

ENSMUSP00000138947.2, ENSMUST00000119965.3

Conserved Domains (1) summary

cd00086
Location:100 → 156

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.